FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040505148> ?p ?o ?g. }

• W2040505148 abstract "DNA polymerase of phage T4 (T4 gp43), an essential component of the T4 DNA replicase, is a multifunctional single-chained (898-amino acid) protein that catalyzes the highly accurate synthesis of DNA in phage replication. The enzyme functions both as a DNA-binding replication protein and as a sequence-specific RNA-binding autogenous translational repressor. We have utilized a phylogenetic approach to study the relationships between the two nucleic acid-binding functions of the protein. We found that autogenous translational control of gp43 biosynthesis has been conserved in phage RB69, a distant relative of T4, although we also found that the RB69 system differs from its T4 counterpart in two regards: (a) nucleotide sequence and predicted secondary structure of the RNA target (translational operator), and (b) RNA specificity of the protein. T4 gp43 is specific to the RNA operator sequence of the T4 genome whereas RB69 gp43 can bind and repress operator RNA from both phages equally well. In studies with T4-RB69 gp43 chimeras, we mapped T4 gp43 RNA-binding specificity to a protein segment that also harbors important determinants for DNA binding and the polymerase catalytic function. Our results suggest that RNA functions as a regulator of both the dosage and activity of this DNA replication enzyme." @default.
• W2040505148 created "2016-06-24" @default.
• W2040505148 creator A5039309678 @default.
• W2040505148 creator A5076391492 @default.
• W2040505148 creator A5077876485 @default.
• W2040505148 date "1997-07-01" @default.
• W2040505148 modified "2023-09-26" @default.
• W2040505148 title "Evolution of RNA-binding Specificity in T4 DNA Polymerase" @default.
• W2040505148 cites W1480540532 @default.
• W2040505148 cites W1509766317 @default.
• W2040505148 cites W1516828376 @default.
• W2040505148 cites W1574555295 @default.
• W2040505148 cites W162291407 @default.
• W2040505148 cites W1657308865 @default.
• W2040505148 cites W1800448312 @default.
• W2040505148 cites W1813130784 @default.
• W2040505148 cites W1824409648 @default.
• W2040505148 cites W1925037468 @default.
• W2040505148 cites W1956312225 @default.
• W2040505148 cites W1970574123 @default.
• W2040505148 cites W1970726343 @default.
• W2040505148 cites W1973968247 @default.
• W2040505148 cites W1975993749 @default.
• W2040505148 cites W1979588488 @default.
• W2040505148 cites W1990951450 @default.
• W2040505148 cites W2005986251 @default.
• W2040505148 cites W2010863207 @default.
• W2040505148 cites W2013060968 @default.
• W2040505148 cites W2017950533 @default.
• W2040505148 cites W2019922918 @default.
• W2040505148 cites W2031580581 @default.
• W2040505148 cites W2034630918 @default.
• W2040505148 cites W2050357018 @default.
• W2040505148 cites W2057910036 @default.
• W2040505148 cites W2078357974 @default.
• W2040505148 cites W2079321730 @default.
• W2040505148 cites W2086269772 @default.
• W2040505148 cites W2088516414 @default.
• W2040505148 cites W2096595259 @default.
• W2040505148 cites W2108449047 @default.
• W2040505148 cites W2133593147 @default.
• W2040505148 cites W2134672977 @default.
• W2040505148 cites W2173265740 @default.
• W2040505148 cites W42006132 @default.
• W2040505148 doi "https://doi.org/10.1074/jbc.272.28.17703" @default.
• W2040505148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9211921" @default.
• W2040505148 hasPublicationYear "1997" @default.
• W2040505148 type Work @default.
• W2040505148 sameAs 2040505148 @default.
• W2040505148 citedByCount "18" @default.
• W2040505148 countsByYear W20405051482014 @default.
• W2040505148 crossrefType "journal-article" @default.
• W2040505148 hasAuthorship W2040505148A5039309678 @default.
• W2040505148 hasAuthorship W2040505148A5076391492 @default.
• W2040505148 hasAuthorship W2040505148A5077876485 @default.
• W2040505148 hasBestOaLocation W20405051481 @default.
• W2040505148 hasConcept C104317684 @default.
• W2040505148 hasConcept C153911025 @default.
• W2040505148 hasConcept C2756471 @default.
• W2040505148 hasConcept C2776449523 @default.
• W2040505148 hasConcept C41258723 @default.
• W2040505148 hasConcept C552990157 @default.
• W2040505148 hasConcept C55493867 @default.
• W2040505148 hasConcept C67705224 @default.
• W2040505148 hasConcept C73573662 @default.
• W2040505148 hasConcept C82381507 @default.
• W2040505148 hasConcept C86803240 @default.
• W2040505148 hasConceptScore W2040505148C104317684 @default.
• W2040505148 hasConceptScore W2040505148C153911025 @default.
• W2040505148 hasConceptScore W2040505148C2756471 @default.
• W2040505148 hasConceptScore W2040505148C2776449523 @default.
• W2040505148 hasConceptScore W2040505148C41258723 @default.
• W2040505148 hasConceptScore W2040505148C552990157 @default.
• W2040505148 hasConceptScore W2040505148C55493867 @default.
• W2040505148 hasConceptScore W2040505148C67705224 @default.
• W2040505148 hasConceptScore W2040505148C73573662 @default.
• W2040505148 hasConceptScore W2040505148C82381507 @default.
• W2040505148 hasConceptScore W2040505148C86803240 @default.
• W2040505148 hasLocation W20405051481 @default.
• W2040505148 hasOpenAccess W2040505148 @default.
• W2040505148 hasPrimaryLocation W20405051481 @default.
• W2040505148 hasRelatedWork W1509686204 @default.
• W2040505148 hasRelatedWork W1509766317 @default.
• W2040505148 hasRelatedWork W1569102428 @default.
• W2040505148 hasRelatedWork W1649575621 @default.
• W2040505148 hasRelatedWork W1800448312 @default.
• W2040505148 hasRelatedWork W1854465589 @default.
• W2040505148 hasRelatedWork W1970574123 @default.
• W2040505148 hasRelatedWork W1981370593 @default.
• W2040505148 hasRelatedWork W1990951450 @default.
• W2040505148 hasRelatedWork W1995250794 @default.
• W2040505148 hasRelatedWork W2039619108 @default.
• W2040505148 hasRelatedWork W2065999793 @default.
• W2040505148 hasRelatedWork W2073768766 @default.
• W2040505148 hasRelatedWork W2076415733 @default.
• W2040505148 hasRelatedWork W2107520545 @default.
• W2040505148 hasRelatedWork W2146379743 @default.
• W2040505148 hasRelatedWork W2236641604 @default.
• W2040505148 hasRelatedWork W2983927338 @default.
• W2040505148 hasRelatedWork W47123523 @default.

• next