FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040506266> ?p ?o ?g. }

• W2040506266 endingPage "510" @default.
• W2040506266 startingPage "504" @default.
• W2040506266 abstract "Polyoxometalates are soluble mineral compounds formed principally of oxide anions and early transition metal cations. The polyoxometalates K12H2[P2W12O48].24H2O (JM 1591), K10[P2W18Zn4(H2O)2O68].20H2O (JM 1596), and [(CH3)3NH]8[Si2W18Nb6O77] (JM 2820) demonstrate potent antiviral activity against human immunodeficiency virus types 1 and 2, herpes simplex virus, and cytomegalovirus in vitro. The preclinical pharmacokinetics of these three compounds were characterized after single-dose intravenous administration of 50 mg/kg to rats. Plasma, urine, and feces were collected for 168 h, and polyoxometalate concentrations were determined by atomic emission. Serum protein binding was measured by equilibrium dialysis. All three compounds were highly bound to serum proteins in a concentration-dependent manner. Total and unbound concentrations of the three compounds in plasma declined in a triexponential manner with terminal half-lives of 246.0 +/- 127.0, 438.4 +/- 129.4, and 32.2 +/- 5.37 h (mean +/- standard deviation) for JM 1591, JM 1596, and JM 2820, respectively. Systemic clearances based on total concentrations in plasma were low, averaging 0.016 +/- 0.002, 0.015 +/- 0.002, and 0.018 +/- 0.003 liter/h/kg for JM 1591, JM 1596, and JM 2820, respectively. The clearances of unbound compounds from plasma averaged 0.966 +/- 0.136, 0.050 +/- 0.005, and 0.901 +/- 0.165 liter/h/kg for JM 1591, JM 1596, and JM 2820, respectively. For JM 1596, the clearance of unbound compound from the kidneys was lower than the glomerular filtration rate (0.086 liter/h/kg), suggesting this polyoxometalate underwent renal tubular reabsorption. However, JM 1591 and JM 2820 appeared to undergo tubular secretion. The fraction of the dose recovered in urine was 11.5, 46.8, and 10.6% for JM 1591, JM 1596, and JM 2820, respectively. Approximately 5% of the dose of each polyoxometalate was recovered in feces. The steady-state volume of distribution based on total concentrations averaged 1.44 liters/kg for JM 1591, 2.39 liters/kg for JM 1596, and 0.59 liter/kg for JM 2820, indicating moderate to wide distribution throughout the body. All three compounds were detected in various tissues 1 week after single-dose administrations, with the highest levels found in the kidneys and liver. The results of this study indicate that the disposition of polyoxometalates is highly dependent on their molecular structure." @default.
• W2040506266 created "2016-06-24" @default.
• W2040506266 creator A5004281002 @default.
• W2040506266 creator A5030738623 @default.
• W2040506266 creator A5033239698 @default.
• W2040506266 creator A5046038305 @default.
• W2040506266 creator A5047170775 @default.
• W2040506266 creator A5048587878 @default.
• W2040506266 creator A5050978587 @default.
• W2040506266 creator A5052877329 @default.
• W2040506266 creator A5063799082 @default.
• W2040506266 creator A5083392344 @default.
• W2040506266 date "1994-03-01" @default.
• W2040506266 modified "2023-10-18" @default.
• W2040506266 title "Pharmacokinetics of antiviral polyoxometalates in rats" @default.
• W2040506266 cites W1937879484 @default.
• W2040506266 cites W1963795573 @default.
• W2040506266 cites W1968896603 @default.
• W2040506266 cites W1979112019 @default.
• W2040506266 cites W1980437255 @default.
• W2040506266 cites W1985293837 @default.
• W2040506266 cites W1992990609 @default.
• W2040506266 cites W1997364324 @default.
• W2040506266 cites W2004423870 @default.
• W2040506266 cites W2016055874 @default.
• W2040506266 cites W2024135875 @default.
• W2040506266 cites W2024476981 @default.
• W2040506266 cites W2026796745 @default.
• W2040506266 cites W2029581385 @default.
• W2040506266 cites W2045795758 @default.
• W2040506266 cites W2046134251 @default.
• W2040506266 cites W2056488857 @default.
• W2040506266 cites W2060201297 @default.
• W2040506266 cites W2061333956 @default.
• W2040506266 cites W2061566909 @default.
• W2040506266 cites W2068058568 @default.
• W2040506266 cites W2072409481 @default.
• W2040506266 cites W2072912951 @default.
• W2040506266 cites W2080314044 @default.
• W2040506266 cites W2086462809 @default.
• W2040506266 cites W2089220512 @default.
• W2040506266 cites W2101713007 @default.
• W2040506266 cites W2106451803 @default.
• W2040506266 cites W2110039810 @default.
• W2040506266 cites W2312444564 @default.
• W2040506266 cites W2322234766 @default.
• W2040506266 cites W2333399282 @default.
• W2040506266 cites W2334860476 @default.
• W2040506266 cites W2409350478 @default.
• W2040506266 cites W2412253154 @default.
• W2040506266 cites W605170700 @default.
• W2040506266 doi "https://doi.org/10.1128/aac.38.3.504" @default.
• W2040506266 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/284488" @default.
• W2040506266 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8203845" @default.
• W2040506266 hasPublicationYear "1994" @default.
• W2040506266 type Work @default.
• W2040506266 sameAs 2040506266 @default.
• W2040506266 citedByCount "28" @default.
• W2040506266 countsByYear W20405062662014 @default.
• W2040506266 countsByYear W20405062662016 @default.
• W2040506266 countsByYear W20405062662017 @default.
• W2040506266 countsByYear W20405062662020 @default.
• W2040506266 countsByYear W20405062662022 @default.
• W2040506266 crossrefType "journal-article" @default.
• W2040506266 hasAuthorship W2040506266A5004281002 @default.
• W2040506266 hasAuthorship W2040506266A5030738623 @default.
• W2040506266 hasAuthorship W2040506266A5033239698 @default.
• W2040506266 hasAuthorship W2040506266A5046038305 @default.
• W2040506266 hasAuthorship W2040506266A5047170775 @default.
• W2040506266 hasAuthorship W2040506266A5048587878 @default.
• W2040506266 hasAuthorship W2040506266A5050978587 @default.
• W2040506266 hasAuthorship W2040506266A5052877329 @default.
• W2040506266 hasAuthorship W2040506266A5063799082 @default.
• W2040506266 hasAuthorship W2040506266A5083392344 @default.
• W2040506266 hasBestOaLocation W20405062662 @default.
• W2040506266 hasConcept C112705442 @default.
• W2040506266 hasConcept C126322002 @default.
• W2040506266 hasConcept C134018914 @default.
• W2040506266 hasConcept C159641895 @default.
• W2040506266 hasConcept C161790260 @default.
• W2040506266 hasConcept C176674119 @default.
• W2040506266 hasConcept C185592680 @default.
• W2040506266 hasConcept C2777498215 @default.
• W2040506266 hasConcept C55493867 @default.
• W2040506266 hasConcept C71924100 @default.
• W2040506266 hasConcept C86803240 @default.
• W2040506266 hasConceptScore W2040506266C112705442 @default.
• W2040506266 hasConceptScore W2040506266C126322002 @default.
• W2040506266 hasConceptScore W2040506266C134018914 @default.
• W2040506266 hasConceptScore W2040506266C159641895 @default.
• W2040506266 hasConceptScore W2040506266C161790260 @default.
• W2040506266 hasConceptScore W2040506266C176674119 @default.
• W2040506266 hasConceptScore W2040506266C185592680 @default.
• W2040506266 hasConceptScore W2040506266C2777498215 @default.
• W2040506266 hasConceptScore W2040506266C55493867 @default.
• W2040506266 hasConceptScore W2040506266C71924100 @default.
• W2040506266 hasConceptScore W2040506266C86803240 @default.
• W2040506266 hasIssue "3" @default.

• next