FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040522014> ?p ?o ?g. }

• W2040522014 endingPage "63" @default.
• W2040522014 startingPage "53" @default.
• W2040522014 abstract "The main goals of the current work were: (a) to assess the ivermectin (IVM) systemic exposure and plasma disposition kinetics after its administration at the recommended dose, x5 and x10 doses to lambs, (b) to compare the clinical efficacy of the same IVM dosages in lambs infected with an IVM-resistant isolate of Haemonchus contortus, and (c) to assess the expression of the transporter protein P-glycoprotein (P-gp) in H. contortus recovered at 14 days after administration of the IVM dose regimens. There were two separated trials where IVM was administered either subcutaneously (SC, Experiment I) or intraruminally (IR, Experiment II). Each experiment involved twenty-four (24) lambs artificially infected with a highly resistant H. contortus isolate. Animals were allocated into 4 groups (n = 6) and treated with IVM at either 0.2 (IVMx1), 1 (IVMx5) or 2 mg/kg (IVMx10). Plasma samples were collected up to 12 days post-treatment and analysed by HPLC. An untreated-control Group was included to assess the comparative anthelmintic efficacy of the different treatments. The level of expression of Pgp in H. contortus specimens obtained from lambs both untreated and IR treated with the different IVM doses was quantified by real time PCR. Parametric and non-parametric tests were used to compare the statistical significance of the results (P < 0.05). After the SC treatment, the IVM plasma area under the concentration–time curve (AUC0–LOQ) increased from 41.9 (IVMSCx1) up to 221 (IVMSCx5) and 287 (IVMSCx10)ng.day/mL and after the IR treatment from 20.8 (IVMIRx1) up to 121 (IVMIRx5) and 323 (IVMIRx10)ng.day/mL. Dose-adjusted AUC0–LOQ and Cmax were similar among doses, demonstrating dose proportionality for IVM after both SC and IR administration at the three different doses. The efficacies against resistant H. contortus after the SC treatment were 42% (IVMSC1), 75% (IVMSCx5) and 75% (IVMSCx10). However, the IR IVM treatment reached clinical efficacies ranging from 48% (IVMIRx1) up to 96% (IVMIRx5) and 98% (IVMIRx10). None of the IR IVM treatments increased the expression of P-gp in adult H. contortus at 14 days post-treatment compared to samples collected from the untreated control group. An enhanced parasite exposure of the drug at the abomasum may explain the improved efficacy against this recalcitrant H. contortus isolate observed only after the IR administration at 5- and 10-fold the IVM therapeutic dosage." @default.
• W2040522014 created "2016-06-24" @default.
• W2040522014 creator A5008247493 @default.
• W2040522014 creator A5012544120 @default.
• W2040522014 creator A5018514731 @default.
• W2040522014 creator A5021336130 @default.
• W2040522014 creator A5026226627 @default.
• W2040522014 creator A5033805892 @default.
• W2040522014 creator A5038468955 @default.
• W2040522014 creator A5041644007 @default.
• W2040522014 creator A5054092174 @default.
• W2040522014 creator A5065954471 @default.
• W2040522014 date "2015-05-01" @default.
• W2040522014 modified "2023-10-16" @default.
• W2040522014 title "Integrated assessment of ivermectin pharmacokinetics, efficacy against resistant Haemonchus contortus and P-glycoprotein expression in lambs treated at three different dosage levels" @default.
• W2040522014 cites W1504724494 @default.
• W2040522014 cites W1546325539 @default.
• W2040522014 cites W1967133850 @default.
• W2040522014 cites W1967275179 @default.
• W2040522014 cites W1971446667 @default.
• W2040522014 cites W1972810374 @default.
• W2040522014 cites W1973569996 @default.
• W2040522014 cites W1975688192 @default.
• W2040522014 cites W1985002789 @default.
• W2040522014 cites W1988371384 @default.
• W2040522014 cites W1989706787 @default.
• W2040522014 cites W2006391573 @default.
• W2040522014 cites W2010230299 @default.
• W2040522014 cites W2014451346 @default.
• W2040522014 cites W2016463464 @default.
• W2040522014 cites W2023005129 @default.
• W2040522014 cites W2025836428 @default.
• W2040522014 cites W2032714373 @default.
• W2040522014 cites W2037156603 @default.
• W2040522014 cites W2038618567 @default.
• W2040522014 cites W2041352976 @default.
• W2040522014 cites W2042449574 @default.
• W2040522014 cites W2061878700 @default.
• W2040522014 cites W2065773720 @default.
• W2040522014 cites W2067650486 @default.
• W2040522014 cites W2070006310 @default.
• W2040522014 cites W2070397171 @default.
• W2040522014 cites W2070516735 @default.
• W2040522014 cites W2072418559 @default.
• W2040522014 cites W2073186293 @default.
• W2040522014 cites W2073841512 @default.
• W2040522014 cites W2073971369 @default.
• W2040522014 cites W2076083530 @default.
• W2040522014 cites W2077012931 @default.
• W2040522014 cites W2085069735 @default.
• W2040522014 cites W2086506918 @default.
• W2040522014 cites W2087930629 @default.
• W2040522014 cites W2091054557 @default.
• W2040522014 cites W2093119139 @default.
• W2040522014 cites W2102990715 @default.
• W2040522014 cites W2107277218 @default.
• W2040522014 cites W2123912605 @default.
• W2040522014 cites W2129944877 @default.
• W2040522014 cites W2146900738 @default.
• W2040522014 cites W2152637109 @default.
• W2040522014 cites W2155291813 @default.
• W2040522014 cites W2155421167 @default.
• W2040522014 cites W2162097287 @default.
• W2040522014 cites W2171658799 @default.
• W2040522014 doi "https://doi.org/10.1016/j.vetpar.2015.03.001" @default.
• W2040522014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25841863" @default.
• W2040522014 hasPublicationYear "2015" @default.
• W2040522014 type Work @default.
• W2040522014 sameAs 2040522014 @default.
• W2040522014 citedByCount "19" @default.
• W2040522014 countsByYear W20405220142015 @default.
• W2040522014 countsByYear W20405220142016 @default.
• W2040522014 countsByYear W20405220142017 @default.
• W2040522014 countsByYear W20405220142018 @default.
• W2040522014 countsByYear W20405220142019 @default.
• W2040522014 countsByYear W20405220142020 @default.
• W2040522014 countsByYear W20405220142021 @default.
• W2040522014 countsByYear W20405220142022 @default.
• W2040522014 countsByYear W20405220142023 @default.
• W2040522014 crossrefType "journal-article" @default.
• W2040522014 hasAuthorship W2040522014A5008247493 @default.
• W2040522014 hasAuthorship W2040522014A5012544120 @default.
• W2040522014 hasAuthorship W2040522014A5018514731 @default.
• W2040522014 hasAuthorship W2040522014A5021336130 @default.
• W2040522014 hasAuthorship W2040522014A5026226627 @default.
• W2040522014 hasAuthorship W2040522014A5033805892 @default.
• W2040522014 hasAuthorship W2040522014A5038468955 @default.
• W2040522014 hasAuthorship W2040522014A5041644007 @default.
• W2040522014 hasAuthorship W2040522014A5054092174 @default.
• W2040522014 hasAuthorship W2040522014A5065954471 @default.
• W2040522014 hasBestOaLocation W20405220142 @default.
• W2040522014 hasConcept C112705442 @default.
• W2040522014 hasConcept C162156334 @default.
• W2040522014 hasConcept C165901193 @default.
• W2040522014 hasConcept C18903297 @default.
• W2040522014 hasConcept C203014093 @default.
• W2040522014 hasConcept C2776908094 @default.
• W2040522014 hasConcept C2777499811 @default.

• next