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- W2040527376 abstract "There are multiple steps in the bacteria–host interaction that lead to colonization. The earliest step is adherence, which in most epithelia means invading the mucin coat of epithelial cells to gain a footing on the epithelium surface. Pier et al.1 Pier G.B. et al. Nature. 1998; 393: 79-82 Crossref PubMed Scopus (266) Google Scholar have found that for Salmonella typhi the next step in the process, internalization, is dependent on the first extracellular loop of the cystic fibrosis transmembrane conductance regulator (CFTR), as evidenced by several techniques. These include inhibition of bacterial uptake by antibodies raised against the first extracellular domain of CFTR (but not other domains), competition for entry by cell lysates containing normal CFTR, and competition by peptides corresponding to the first extracellular loop but not the first transmembrane segment. Another closely related species, Salmonella typhimurium, does not use CFTR for entry but enters host cells by means of the bacterial invasion protein, InvJ, which is secreted by this bacterium when epithelial cells or media containing these cells are present 2 Galan J.E. Curtiss III., R. Proc. Natl. Acad. Sci. U. S. A. 1989; 86: 6383-6387 Crossref PubMed Scopus (749) Google Scholar . Evolution of the ΔF508 CFTR mutation: ResponseGerald B PierTrends in MicrobiologyFebruary 01, 1999In Brief Full-Text PDF" @default.
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- W2040527376 date "1999-02-01" @default.
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- W2040527376 title "Evolution of the ΔF508 CFTR mutation" @default.
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- W2040527376 doi "https://doi.org/10.1016/s0966-842x(98)01442-5" @default.
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