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- W2040532208 abstract "A reflection-based localized surface plasma resonance fiber-optic probe for chemical and biochemical sensing, called fiber-optic localized plasma resonance (FO-LPR), has been proposed in the literature. Bio-molecular recognition is detected by the unique optical properties of self-assembled gold nanoparticles on the unclad portions of an optical fiber whose surfaces are modified with a receptor. To enhance the performance of the sensing platform, the sensing element is integrated with microfluidic chips to reduce sample and reagent volume, to shorten response time and analysis time, as well as to increase sensitivity. The main purpose of the present study is to simulate the biochemical assays in the FO-LPR microfluidic chip and to investigate the effects parameters, such as inlet concentrations of analyte or the flowrate on the biochemical binding kinetics. The geometry of the grooved channel is also proposed to enhance the biochemical binding on the unclad optical fiber. The results reveal that the chaotic mixing generated by the grooves enhances the biochemical binding when the injected flowrate is high and, because of that, limits the performance of the molecular mixing. The enhancement of biochemical binding performance was significant, especially at the low injected concentration of analyte." @default.
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- W2040532208 date "2009-04-01" @default.
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- W2040532208 title "Simulation of biochemical binding kinetics on the microfluidic biochip of fiber-optic localized plasma resonance (FO-LPR)" @default.
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- W2040532208 doi "https://doi.org/10.1016/j.mee.2008.12.084" @default.
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