FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040542810> ?p ?o ?g. }

• W2040542810 abstract "The effect of the steroidal androgen receptor antagonist Win 49,596 on the prostate and testis was studied in beagle dogs and was compared to the effects of the nonsteroidal androgen receptor antagonist ICI 176,334 and the steroidal 5 alpha-reductase inhibitor MK-906. Win 49,596 was shown to bind to the androgen receptor from normal canine prostate with a Ki of 2.2 microM. After 16 weeks of treatment, prostate size, as estimated by transrectal ultrasonography, was unchanged in intact controls and was 26% of the initial size in castrate controls. Oral doses of Win 49,596 from 0.625-40 mg/kg.day for 16 weeks caused dose-dependent prostatic regression and a dose-related increase in both the incidence and severity of glandular atrophy of the prostate. Prostatic secretory function was also inhibited by Win 49,596 treatment. The effects of Win 49,596 at 40 mg/kg.day on prostatic weight, total DNA, histomorphology, and secretory function were similar to those of castration, while the effects of Win 49,596 at 10 mg/kg.day were similar to those of ICI 176,334 at 0.25 mg/kg.day and MK-906 at 1.0 mg/kg.day. No effects on testicular weight, daily sperm production, or spermatogenesis were observed; however, mild Leydig cell hyperplasia was observed in two dogs treated with 40 mg/kg.day Win 49,596. In addition, at 10 and 40 mg/kg.day Win 49,596, moderate but variable increases in serum testosterone levels were observed. In summary, Win 49,596 caused regression of the hypertrophic canine prostate without effects on spermatogenesis and/or sexual function, supporting its possible use in the treatment of human benign prostatic hypertrophy/hyperplasia." @default.
• W2040542810 created "2016-06-24" @default.
• W2040542810 creator A5003331208 @default.
• W2040542810 creator A5007092725 @default.
• W2040542810 creator A5008606670 @default.
• W2040542810 creator A5027808633 @default.
• W2040542810 creator A5030111888 @default.
• W2040542810 creator A5030341537 @default.
• W2040542810 creator A5053583356 @default.
• W2040542810 creator A5054038555 @default.
• W2040542810 creator A5054598637 @default.
• W2040542810 date "1990-05-01" @default.
• W2040542810 modified "2023-09-27" @default.
• W2040542810 title "The Effect of the Steroidal Androgen Receptor Antagonist, Win 49,596, on the Prostate and Testis of Beagle Dogs" @default.
• W2040542810 cites W1479893295 @default.
• W2040542810 cites W1564322863 @default.
• W2040542810 cites W184029216 @default.
• W2040542810 cites W1975808686 @default.
• W2040542810 cites W1992798660 @default.
• W2040542810 cites W1993285058 @default.
• W2040542810 cites W1997865622 @default.
• W2040542810 cites W2001730606 @default.
• W2040542810 cites W2008481614 @default.
• W2040542810 cites W2020006391 @default.
• W2040542810 cites W2030630196 @default.
• W2040542810 cites W2032789452 @default.
• W2040542810 cites W2043150609 @default.
• W2040542810 cites W2043352912 @default.
• W2040542810 cites W2056240711 @default.
• W2040542810 cites W2059902276 @default.
• W2040542810 cites W2067100745 @default.
• W2040542810 cites W2073619988 @default.
• W2040542810 cites W2092666751 @default.
• W2040542810 cites W2093410615 @default.
• W2040542810 cites W2094062186 @default.
• W2040542810 cites W2096001183 @default.
• W2040542810 cites W2102337416 @default.
• W2040542810 cites W2110712857 @default.
• W2040542810 cites W2151389580 @default.
• W2040542810 cites W2160477000 @default.
• W2040542810 cites W2165686313 @default.
• W2040542810 cites W2317667670 @default.
• W2040542810 cites W2318158772 @default.
• W2040542810 cites W2395181925 @default.
• W2040542810 cites W2397648458 @default.
• W2040542810 cites W2463287394 @default.
• W2040542810 doi "https://doi.org/10.1210/endo-126-5-2625" @default.
• W2040542810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1691701" @default.
• W2040542810 hasPublicationYear "1990" @default.
• W2040542810 type Work @default.
• W2040542810 sameAs 2040542810 @default.
• W2040542810 citedByCount "29" @default.
• W2040542810 countsByYear W20405428102017 @default.
• W2040542810 countsByYear W20405428102018 @default.
• W2040542810 countsByYear W20405428102019 @default.
• W2040542810 crossrefType "journal-article" @default.
• W2040542810 hasAuthorship W2040542810A5003331208 @default.
• W2040542810 hasAuthorship W2040542810A5007092725 @default.
• W2040542810 hasAuthorship W2040542810A5008606670 @default.
• W2040542810 hasAuthorship W2040542810A5027808633 @default.
• W2040542810 hasAuthorship W2040542810A5030111888 @default.
• W2040542810 hasAuthorship W2040542810A5030341537 @default.
• W2040542810 hasAuthorship W2040542810A5053583356 @default.
• W2040542810 hasAuthorship W2040542810A5054038555 @default.
• W2040542810 hasAuthorship W2040542810A5054598637 @default.
• W2040542810 hasConcept C121608353 @default.
• W2040542810 hasConcept C123765429 @default.
• W2040542810 hasConcept C126322002 @default.
• W2040542810 hasConcept C134018914 @default.
• W2040542810 hasConcept C170493617 @default.
• W2040542810 hasConcept C2776235491 @default.
• W2040542810 hasConcept C2776820430 @default.
• W2040542810 hasConcept C2776885963 @default.
• W2040542810 hasConcept C2777562237 @default.
• W2040542810 hasConcept C2777911890 @default.
• W2040542810 hasConcept C2779256933 @default.
• W2040542810 hasConcept C2779279991 @default.
• W2040542810 hasConcept C2780192828 @default.
• W2040542810 hasConcept C61367390 @default.
• W2040542810 hasConcept C71315377 @default.
• W2040542810 hasConcept C71924100 @default.
• W2040542810 hasConceptScore W2040542810C121608353 @default.
• W2040542810 hasConceptScore W2040542810C123765429 @default.
• W2040542810 hasConceptScore W2040542810C126322002 @default.
• W2040542810 hasConceptScore W2040542810C134018914 @default.
• W2040542810 hasConceptScore W2040542810C170493617 @default.
• W2040542810 hasConceptScore W2040542810C2776235491 @default.
• W2040542810 hasConceptScore W2040542810C2776820430 @default.
• W2040542810 hasConceptScore W2040542810C2776885963 @default.
• W2040542810 hasConceptScore W2040542810C2777562237 @default.
• W2040542810 hasConceptScore W2040542810C2777911890 @default.
• W2040542810 hasConceptScore W2040542810C2779256933 @default.
• W2040542810 hasConceptScore W2040542810C2779279991 @default.
• W2040542810 hasConceptScore W2040542810C2780192828 @default.
• W2040542810 hasConceptScore W2040542810C61367390 @default.
• W2040542810 hasConceptScore W2040542810C71315377 @default.
• W2040542810 hasConceptScore W2040542810C71924100 @default.
• W2040542810 hasLocation W20405428101 @default.
• W2040542810 hasLocation W20405428102 @default.
• W2040542810 hasOpenAccess W2040542810 @default.

• next