FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040543350> ?p ?o ?g. }

• W2040543350 endingPage "53" @default.
• W2040543350 startingPage "47" @default.
• W2040543350 abstract "We reported previously that in African green monkey (AGM) CD4 lymphocytes, CD4 mRNA expression undergoes a decrease following in vitro activation, and CD4 cells are therefore subject to loss of CD4 expression on the cell surface. To examine the transcriptional regulation of the CD4 gene in this species, we analyzed the CD4 silencer, which has been identified as a regulatory element responsible for the down regulation of CD4 transcription in CD8 cell lineage cells. Sequence analysis indicated that the CD4 silencer of the AGM was highly homologous to that of humans. However, two nucleotide substitutions were present in one of the nuclear protein binding sites, which was characterized as the FP II site having a strong enhancing effect on transgene expression in CD4 cells. By performing transient transfection assays, we found that the enhancing activities of the CD4 silencer or FP II-containing fragment of the AGM were greatly reduced in a human CD4 cell line as compared to those of human materials. The CD4 mRNA level was significantly decreased in the human CD4 cell line when synthetic oligonucleotide corresponding to the human FP II sequence was added to the culture. These observations imply that FP II-protein interaction might be required for the maintenance of sufficient expression of the CD4 gene, and the enhancing activity mediated by the above interaction might be decreased in the AGM CD4 silencer, due probably to the nucleotide changes occurring at the FP II site." @default.
• W2040543350 created "2016-06-24" @default.
• W2040543350 creator A5026420420 @default.
• W2040543350 creator A5059296049 @default.
• W2040543350 creator A5063468141 @default.
• W2040543350 creator A5064231127 @default.
• W2040543350 creator A5076853511 @default.
• W2040543350 date "2000-12-01" @default.
• W2040543350 modified "2023-10-11" @default.
• W2040543350 title "Sequence and functional properties of African green monkey CD4 silencer" @default.
• W2040543350 cites W15081168 @default.
• W2040543350 cites W1678774408 @default.
• W2040543350 cites W1954521430 @default.
• W2040543350 cites W1963058400 @default.
• W2040543350 cites W1974723750 @default.
• W2040543350 cites W1976852696 @default.
• W2040543350 cites W1989249686 @default.
• W2040543350 cites W2009157415 @default.
• W2040543350 cites W2030213745 @default.
• W2040543350 cites W2061745432 @default.
• W2040543350 cites W2134122569 @default.
• W2040543350 cites W2143502309 @default.
• W2040543350 cites W2147278264 @default.
• W2040543350 cites W2165832185 @default.
• W2040543350 cites W2169114649 @default.
• W2040543350 cites W2275766202 @default.
• W2040543350 cites W2413859809 @default.
• W2040543350 doi "https://doi.org/10.1016/s0165-2478(00)00273-x" @default.
• W2040543350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11163866" @default.
• W2040543350 hasPublicationYear "2000" @default.
• W2040543350 type Work @default.
• W2040543350 sameAs 2040543350 @default.
• W2040543350 citedByCount "7" @default.
• W2040543350 countsByYear W20405433502013 @default.
• W2040543350 countsByYear W20405433502019 @default.
• W2040543350 countsByYear W20405433502020 @default.
• W2040543350 crossrefType "journal-article" @default.
• W2040543350 hasAuthorship W2040543350A5026420420 @default.
• W2040543350 hasAuthorship W2040543350A5059296049 @default.
• W2040543350 hasAuthorship W2040543350A5063468141 @default.
• W2040543350 hasAuthorship W2040543350A5064231127 @default.
• W2040543350 hasAuthorship W2040543350A5076853511 @default.
• W2040543350 hasConcept C104317684 @default.
• W2040543350 hasConcept C105580179 @default.
• W2040543350 hasConcept C127413603 @default.
• W2040543350 hasConcept C129312508 @default.
• W2040543350 hasConcept C138885662 @default.
• W2040543350 hasConcept C147483822 @default.
• W2040543350 hasConcept C150194340 @default.
• W2040543350 hasConcept C153911025 @default.
• W2040543350 hasConcept C167672396 @default.
• W2040543350 hasConcept C179926584 @default.
• W2040543350 hasConcept C190414344 @default.
• W2040543350 hasConcept C201289731 @default.
• W2040543350 hasConcept C21592294 @default.
• W2040543350 hasConcept C41895202 @default.
• W2040543350 hasConcept C54009773 @default.
• W2040543350 hasConcept C54355233 @default.
• W2040543350 hasConcept C78519656 @default.
• W2040543350 hasConcept C81885089 @default.
• W2040543350 hasConcept C86803240 @default.
• W2040543350 hasConcept C95444343 @default.
• W2040543350 hasConceptScore W2040543350C104317684 @default.
• W2040543350 hasConceptScore W2040543350C105580179 @default.
• W2040543350 hasConceptScore W2040543350C127413603 @default.
• W2040543350 hasConceptScore W2040543350C129312508 @default.
• W2040543350 hasConceptScore W2040543350C138885662 @default.
• W2040543350 hasConceptScore W2040543350C147483822 @default.
• W2040543350 hasConceptScore W2040543350C150194340 @default.
• W2040543350 hasConceptScore W2040543350C153911025 @default.
• W2040543350 hasConceptScore W2040543350C167672396 @default.
• W2040543350 hasConceptScore W2040543350C179926584 @default.
• W2040543350 hasConceptScore W2040543350C190414344 @default.
• W2040543350 hasConceptScore W2040543350C201289731 @default.
• W2040543350 hasConceptScore W2040543350C21592294 @default.
• W2040543350 hasConceptScore W2040543350C41895202 @default.
• W2040543350 hasConceptScore W2040543350C54009773 @default.
• W2040543350 hasConceptScore W2040543350C54355233 @default.
• W2040543350 hasConceptScore W2040543350C78519656 @default.
• W2040543350 hasConceptScore W2040543350C81885089 @default.
• W2040543350 hasConceptScore W2040543350C86803240 @default.
• W2040543350 hasConceptScore W2040543350C95444343 @default.
• W2040543350 hasIssue "1" @default.
• W2040543350 hasLocation W20405433501 @default.
• W2040543350 hasLocation W20405433502 @default.
• W2040543350 hasOpenAccess W2040543350 @default.
• W2040543350 hasPrimaryLocation W20405433501 @default.
• W2040543350 hasRelatedWork W1841064011 @default.
• W2040543350 hasRelatedWork W2018403838 @default.
• W2040543350 hasRelatedWork W2312045984 @default.
• W2040543350 hasRelatedWork W2391098226 @default.
• W2040543350 hasRelatedWork W3036649455 @default.
• W2040543350 hasRelatedWork W4236214364 @default.
• W2040543350 hasRelatedWork W4254473908 @default.
• W2040543350 hasRelatedWork W4256047291 @default.
• W2040543350 hasRelatedWork W4283068785 @default.
• W2040543350 hasRelatedWork W4313515450 @default.
• W2040543350 hasVolume "75" @default.

• next