FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040544078> ?p ?o ?g. }

• W2040544078 endingPage "15311" @default.
• W2040544078 startingPage "15306" @default.
• W2040544078 abstract "Although the simultaneous engagement of multiple effector mechanisms is thought to characterize optimal CD8(+) T-cell immunity and facilitate pathogen clearance, the differentiation pathways leading to the acquisition and maintenance of such polyfunctional activity are not well understood. Division-dependent profiles of effector molecule expression for virus-specific T cells are analyzed here by using a combination of carboxyfluorescein succinimidyl ester dilution and intracellular cytokine staining subsequent to T-cell receptor ligation. The experiments show that, although the majority of naive CD8(+) T-cell precursors are preprogrammed to produce TNF-α soon after stimulation and a proportion make both TNF-α and IL-2, the progressive acquisition of IFN-γ expression depends on continued lymphocyte proliferation. Furthermore, the extensive division characteristic of differentiation to peak effector activity is associated with the progressive dominance of IFN-γ and the concomitant loss of polyfunctional cytokine production, although this is not apparent for long-term CD8(+) T-cell memory. Such proliferation-dependent variation in cytokine production appears tied to the epigenetic signatures within the ifnG and tnfA proximal promoters. Specifically, those cytokine gene loci that are rapidly expressed following antigen stimulation at different stages of T-cell differentiation can be shown (by ChIP) to have permissive epigenetic and RNA polymerase II docking signatures. Thus, the dynamic changes in cytokine profiles for naive, effector, and memory T cells are underpinned by specific epigenetic landscapes that regulate responsiveness following T-cell receptor ligation." @default.
• W2040544078 created "2016-06-24" @default.
• W2040544078 creator A5003005203 @default.
• W2040544078 creator A5013317014 @default.
• W2040544078 creator A5043557085 @default.
• W2040544078 creator A5051259149 @default.
• W2040544078 creator A5074692390 @default.
• W2040544078 date "2011-08-29" @default.
• W2040544078 modified "2023-10-02" @default.
• W2040544078 title "Differentiation-dependent functional and epigenetic landscapes for cytokine genes in virus-specific CD8 ⁺ T cells" @default.
• W2040544078 cites W1481208898 @default.
• W2040544078 cites W1490351768 @default.
• W2040544078 cites W1499361076 @default.
• W2040544078 cites W1531797215 @default.
• W2040544078 cites W1579635462 @default.
• W2040544078 cites W1636607180 @default.
• W2040544078 cites W1862322995 @default.
• W2040544078 cites W1962164504 @default.
• W2040544078 cites W1964741953 @default.
• W2040544078 cites W1974433492 @default.
• W2040544078 cites W1981027928 @default.
• W2040544078 cites W1985293294 @default.
• W2040544078 cites W1990287810 @default.
• W2040544078 cites W1994340334 @default.
• W2040544078 cites W2008354811 @default.
• W2040544078 cites W2008750159 @default.
• W2040544078 cites W2017669223 @default.
• W2040544078 cites W2031716096 @default.
• W2040544078 cites W2041574566 @default.
• W2040544078 cites W2041658172 @default.
• W2040544078 cites W2059551822 @default.
• W2040544078 cites W2064656497 @default.
• W2040544078 cites W2083245183 @default.
• W2040544078 cites W2085402152 @default.
• W2040544078 cites W2091218020 @default.
• W2040544078 cites W2092345398 @default.
• W2040544078 cites W2093628080 @default.
• W2040544078 cites W2096083625 @default.
• W2040544078 cites W2114866609 @default.
• W2040544078 cites W2126604656 @default.
• W2040544078 cites W2126929750 @default.
• W2040544078 cites W2128401657 @default.
• W2040544078 cites W2131881730 @default.
• W2040544078 cites W2133938268 @default.
• W2040544078 cites W2137478600 @default.
• W2040544078 cites W2138323449 @default.
• W2040544078 cites W2138773604 @default.
• W2040544078 cites W2139238700 @default.
• W2040544078 cites W2140485864 @default.
• W2040544078 cites W2147701937 @default.
• W2040544078 cites W2154353245 @default.
• W2040544078 cites W2157493506 @default.
• W2040544078 cites W2161084802 @default.
• W2040544078 cites W2165093739 @default.
• W2040544078 doi "https://doi.org/10.1073/pnas.1112520108" @default.
• W2040544078 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3174616" @default.
• W2040544078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21876173" @default.
• W2040544078 hasPublicationYear "2011" @default.
• W2040544078 type Work @default.
• W2040544078 sameAs 2040544078 @default.
• W2040544078 citedByCount "87" @default.
• W2040544078 countsByYear W20405440782012 @default.
• W2040544078 countsByYear W20405440782013 @default.
• W2040544078 countsByYear W20405440782014 @default.
• W2040544078 countsByYear W20405440782015 @default.
• W2040544078 countsByYear W20405440782016 @default.
• W2040544078 countsByYear W20405440782017 @default.
• W2040544078 countsByYear W20405440782018 @default.
• W2040544078 countsByYear W20405440782019 @default.
• W2040544078 countsByYear W20405440782020 @default.
• W2040544078 countsByYear W20405440782021 @default.
• W2040544078 countsByYear W20405440782022 @default.
• W2040544078 countsByYear W20405440782023 @default.
• W2040544078 crossrefType "journal-article" @default.
• W2040544078 hasAuthorship W2040544078A5003005203 @default.
• W2040544078 hasAuthorship W2040544078A5013317014 @default.
• W2040544078 hasAuthorship W2040544078A5043557085 @default.
• W2040544078 hasAuthorship W2040544078A5051259149 @default.
• W2040544078 hasAuthorship W2040544078A5074692390 @default.
• W2040544078 hasBestOaLocation W20405440781 @default.
• W2040544078 hasConcept C104317684 @default.
• W2040544078 hasConcept C147483822 @default.
• W2040544078 hasConcept C154317977 @default.
• W2040544078 hasConcept C167672396 @default.
• W2040544078 hasConcept C202751555 @default.
• W2040544078 hasConcept C203014093 @default.
• W2040544078 hasConcept C2776090121 @default.
• W2040544078 hasConcept C2778690821 @default.
• W2040544078 hasConcept C41091548 @default.
• W2040544078 hasConcept C51785407 @default.
• W2040544078 hasConcept C54355233 @default.
• W2040544078 hasConcept C86803240 @default.
• W2040544078 hasConcept C8891405 @default.
• W2040544078 hasConcept C95444343 @default.
• W2040544078 hasConceptScore W2040544078C104317684 @default.
• W2040544078 hasConceptScore W2040544078C147483822 @default.
• W2040544078 hasConceptScore W2040544078C154317977 @default.
• W2040544078 hasConceptScore W2040544078C167672396 @default.

• next