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- W2040551027 abstract "The coupling mechanism between depletion of Ca(2+) stores in the endoplasmic reticulum and plasma membrane store-operated ion channels is fundamental to Ca(2+) signaling in many cell types and has yet to be completely elucidated. Using Ca(2+) release-activated Ca(2+) (CRAC) channels in RBL-2H3 cells as a model system, we have shown that CRAC channels are maintained in the closed state by an inhibitory factor rather than being opened by the inositol 1,4,5-trisphosphate receptor. This inhibitory role can be fulfilled by the Drosophila protein INAD (inactivation-no after potential D). The action of INAD requires Ca(2+) and can be reversed by a diffusible Ca(2+) influx factor. Thus the coupling between the depletion of Ca(2+) stores and the activation of CRAC channels may involve a mammalian homologue of INAD and a low-molecular-weight, diffusible store-depletion signal." @default.
- W2040551027 created "2016-06-24" @default.
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- W2040551027 date "2003-02-01" @default.
- W2040551027 modified "2023-09-27" @default.
- W2040551027 title "Regulation of Ca2+release-activated Ca2+channels by INAD and Ca2+influx factor" @default.
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- W2040551027 doi "https://doi.org/10.1152/ajpcell.00183.2002" @default.
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