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- W2040552024 abstract "Abstract Aim The present study was aimed to evaluate the antioxidant property and hypoglycemic activity of aqueous and ethanolic extracts of aerial parts of Grewia serrulata DC (AEGS & EEGS) in normal and hyperglycemic male Wistar Albino rats. Methods The antioxidant property was evaluated both in vitro and in vivo model using standard procedures. The hypoglycemic activity was evaluated by normal glucose and oral glucose tolerance test (NG-OGTT) method and by acute administration of AEGS and EEGS extracts at doses 200 and 400 mg/kg body wt p.o in Streptozotocin (STZ) induced hyperglycemic rats. Results The ethanolic extract of Grewia serrulata DC exhibited strong free radical scavenging activity as evidenced by their low IC 50 values in DPPH (1,1-diphenyl-2-picryl-hydrazyl) (9.16 ± 1.05 μg/ml), Superoxide (35.59 ± 1.6805 μg/ml) and nitric oxide (151.80 ± 1.79 μg/ml) methods. In in vivo study, treatment with ethanolic extract at both doses shows a significant dose dependent increase ( p p p p 4 treated control in both liver and kidney. In NG-OGTT method EEGS shows reduction in glucose levels in normal rats and glucose loaded hyperglycemic rats and in STZ-induced hyperglycemic rats. Conclusion EEGS was found to possess strong antioxidant activity and good hypoglycemic activity compared to that of AEGS." @default.
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- W2040552024 date "2013-08-01" @default.
- W2040552024 modified "2023-09-26" @default.
- W2040552024 title "Antioxidant property of Grewia serrulata DC and its hypoglycemic effect on normal and hyperglycemic rats" @default.
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- W2040552024 doi "https://doi.org/10.1016/j.jopr.2013.08.004" @default.
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