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• W2040552971 endingPage "1217" @default.
• W2040552971 startingPage "1211" @default.
• W2040552971 abstract "Somatostatin is a neurotransmitter with diverse effects including anti-proliferation in a wide range of normal and neoplastic cells, and occasionally growth stimulatory and neurotrophic actions. Stress-activated protein kinase or c-Jun N-terminal kinase (SAPK/JNK) can also induce growth arrest and occasionally growth stimulation. However, the relationship between somatostatin and SAPK/JNK is less clear. Here we report that the binding of somatostatin to the somatostatin receptor type V (SSTR5) upregulates SAPK/JNK activity. We also show that this activation is mediated by Gα12 and Gα13. This study demonstrates that SSTR5 is the heptahelical receptor that activates SAPK/JNK via the G12 family G proteins." @default.
• W2040552971 created "2016-06-24" @default.
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• W2040552971 date "2001-12-01" @default.
• W2040552971 modified "2023-09-26" @default.
• W2040552971 title "Somatostatin Type V Receptor Activates c-Jun N-Terminal Kinases via Gα12 Family G Proteins" @default.
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• W2040552971 doi "https://doi.org/10.1006/bbrc.2001.6085" @default.
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