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- W2040553265 abstract "Lennox-Gastaut syndrome is a severe childhood epilepsy disorder characterized by encephalopathy and multiple, often intractable, seizure types. The drop attack is the most frequently recognizable seizure type in this patient population, and is also the most dangerous physically, thus severely limiting quality of life. The diagnosis is confirmed by electroencephalography, for which the classic pattern is a slow 2.5 Hz generalized spike-and-wave. Newer pharmacologic treatments include rufinimide and clobazam. However, antiepileptic drugs are often exhausted in pursuit of seizure control requiring nonpharmacologic interventions. These include dietary therapies, vagus nerve stimulation, and epilepsy surgery, including corpus callosotomy and focal curative resection. Although large lobar resections are often required, very localized, discrete resections may be possible, as in symptomatic Lennox-Gastaut syndrome (specifically, hypothalamic hamartoma). We review the history of the disease and current management options." @default.
- W2040553265 created "2016-06-24" @default.
- W2040553265 creator A5050110480 @default.
- W2040553265 creator A5070986281 @default.
- W2040553265 date "2012-09-01" @default.
- W2040553265 modified "2023-10-18" @default.
- W2040553265 title "Update on the Management of Lennox-Gastaut Syndrome" @default.
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- W2040553265 doi "https://doi.org/10.1016/j.pediatrneurol.2012.05.001" @default.
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