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- W2040553621 abstract "Scope Chronic sustained hyperglycemia underlies the symptomatology and complications of type 2 diabetes mellitus, and dietary components contribute to it. Germinated brown rice ( GBR ) improves glycemic control but the mechanisms involved are still the subject of debate. We now show one mechanism by which GBR lowers blood glucose. Methods and results Effects of GBR , brown rice, and white rice ( WR ) on fasting plasma glucose and selected genes were studied in type 2 diabetic rats. GBR reduced plasma glucose and weight more than metformin, while WR worsened glycemia over 4 weeks of intervention. Through nutrigenomic suppression, GBR downregulated gluconeogenic genes ( F bp1 and P ck1 ) in a manner similar to, but more potently than, metformin, while WR upregulated the same genes. Bioactives (gamma‐amino butyric acid, acylated steryl glycoside, oryzanol, and phenolics) were involved in GBR 's downregulation of both genes. Plasma glucose, F bp1 and P ck1 changes significantly affected the weight of rats ( p = 0.0001). Conclusion The fact that GBR downregulates gluconeogenic genes similar to metformin, but produces better glycemic control in type 2 diabetic rats, suggests other mechanisms are involved in GBR 's antihyperglycemic properties. GBR as a staple could potentially provide enhanced glycemic control in type 2 diabetes mellitus better than metformin." @default.
- W2040553621 created "2016-06-24" @default.
- W2040553621 creator A5019508937 @default.
- W2040553621 creator A5069761481 @default.
- W2040553621 date "2013-01-10" @default.
- W2040553621 modified "2023-10-17" @default.
- W2040553621 title "Nutrigenomic effects of germinated brown rice and its bioactives on hepatic gluconeogenic genes in type 2 diabetic rats and HEPG2 cells" @default.
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- W2040553621 doi "https://doi.org/10.1002/mnfr.201200429" @default.
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