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- W2040554400 abstract "Astrocytes persistently infected with HIV-1 can transmit virus to CD4+ cells, suggesting that astrocytes may be a source of viral persistence and dissemination in the brain. In the present study, we investigated the fate of HIV-1 upon infection of astrocytes. HIV-1 was observed in vesicle-like structures. Unspliced genomic RNA and extrachromosomal HIV-1 DNA were detected in astrocytes, with levels declining over time. The extrachromosomal viral DNA was not de novo reverse transcribed in astrocytes but most likely the products of intravirion reverse transcription present in the virus inoculum. Integrated HIV-1 DNA was not detected in assays sensitive to detect 2 integrated copies of provirus. However, the majority of astrocyte cultures released infectious virus that could be transmitted to CD4+ cells. Our findings suggest a novel pathway of HIV-1 uptake and release in astrocytes that does not necessarily require virus replication, which may contribute to persistence and spread of HIV-1 in the brain." @default.
- W2040554400 created "2016-06-24" @default.
- W2040554400 creator A5010715416 @default.
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- W2040554400 creator A5074447167 @default.
- W2040554400 creator A5079445996 @default.
- W2040554400 creator A5091208578 @default.
- W2040554400 date "2006-04-01" @default.
- W2040554400 modified "2023-10-07" @default.
- W2040554400 title "Novel pathway of human immunodeficiency virus type 1 uptake and release in astrocytes" @default.
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- W2040554400 doi "https://doi.org/10.1016/j.virol.2005.12.004" @default.
- W2040554400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16445956" @default.
- W2040554400 hasPublicationYear "2006" @default.
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