FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040557851> ?p ?o ?g. }

• W2040557851 endingPage "7896" @default.
• W2040557851 startingPage "7892" @default.
• W2040557851 abstract "Previous work showed that the expression of the Escherichia coli threonine:tRNAThr ligase (EC 6.1.1.3)-encoding gene (thrS) is negatively autoregulated at the translational level and that a region called the operator that is located between 10 and 50 base pairs upstream of the translation initiation codon of the thrS gene is directly involved in that control. The conformation of an in vitro synthesized RNA fragment extending over the thrS regulatory region has been investigated using chemical and enzymatic probes. This study shows that the RNA folds into four well-defined secondary-structure domains, one of them displaying structural similarities to the anticodon arm of tRNAThr. The conformation of three constitutive mutants containing single base changes in the operator region leading to the loss of the regulatory control was also investigated. The replacement of a base in the anticodon-like loop does not induce any conformational change, suggesting that the residue concerned is directly involved in the regulatory process. However, single mutations in or close to the anticodon-like stem result in a partial or complete reorganization of the structure of the operator region. These rearrangements should affect the binding of the ligase to the operator, leading to loss of the regulatory process." @default.
• W2040557851 created "2016-06-24" @default.
• W2040557851 creator A5004181380 @default.
• W2040557851 creator A5007837003 @default.
• W2040557851 creator A5024980365 @default.
• W2040557851 creator A5065701072 @default.
• W2040557851 creator A5067408390 @default.
• W2040557851 creator A5087131734 @default.
• W2040557851 creator A5091847535 @default.
• W2040557851 date "1988-11-01" @default.
• W2040557851 modified "2023-09-26" @default.
• W2040557851 title "Messenger RNA structure and gene regulation at the translational level in Escherichia coli: the case of threonine:tRNAThr ligase." @default.
• W2040557851 cites W1483611500 @default.
• W2040557851 cites W1509757910 @default.
• W2040557851 cites W1564666527 @default.
• W2040557851 cites W1963899534 @default.
• W2040557851 cites W1981777358 @default.
• W2040557851 cites W1990794432 @default.
• W2040557851 cites W2010080704 @default.
• W2040557851 cites W2010346856 @default.
• W2040557851 cites W2035728389 @default.
• W2040557851 cites W2044410490 @default.
• W2040557851 cites W2050273964 @default.
• W2040557851 cites W2068012649 @default.
• W2040557851 cites W2073307682 @default.
• W2040557851 cites W2078119356 @default.
• W2040557851 cites W2085866164 @default.
• W2040557851 cites W2087578050 @default.
• W2040557851 cites W2095224668 @default.
• W2040557851 cites W2114767715 @default.
• W2040557851 cites W2191259987 @default.
• W2040557851 cites W263820944 @default.
• W2040557851 cites W972132498 @default.
• W2040557851 doi "https://doi.org/10.1073/pnas.85.21.7892" @default.
• W2040557851 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/282304" @default.
• W2040557851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3054873" @default.
• W2040557851 hasPublicationYear "1988" @default.
• W2040557851 type Work @default.
• W2040557851 sameAs 2040557851 @default.
• W2040557851 citedByCount "45" @default.
• W2040557851 countsByYear W20405578512012 @default.
• W2040557851 countsByYear W20405578512014 @default.
• W2040557851 countsByYear W20405578512017 @default.
• W2040557851 countsByYear W20405578512019 @default.
• W2040557851 countsByYear W20405578512021 @default.
• W2040557851 countsByYear W20405578512023 @default.
• W2040557851 crossrefType "journal-article" @default.
• W2040557851 hasAuthorship W2040557851A5004181380 @default.
• W2040557851 hasAuthorship W2040557851A5007837003 @default.
• W2040557851 hasAuthorship W2040557851A5024980365 @default.
• W2040557851 hasAuthorship W2040557851A5065701072 @default.
• W2040557851 hasAuthorship W2040557851A5067408390 @default.
• W2040557851 hasAuthorship W2040557851A5087131734 @default.
• W2040557851 hasAuthorship W2040557851A5091847535 @default.
• W2040557851 hasBestOaLocation W20405578511 @default.
• W2040557851 hasConcept C104317684 @default.
• W2040557851 hasConcept C134459356 @default.
• W2040557851 hasConcept C143065580 @default.
• W2040557851 hasConcept C153957851 @default.
• W2040557851 hasConcept C175114707 @default.
• W2040557851 hasConcept C185581394 @default.
• W2040557851 hasConcept C25602115 @default.
• W2040557851 hasConcept C54355233 @default.
• W2040557851 hasConcept C547475151 @default.
• W2040557851 hasConcept C55493867 @default.
• W2040557851 hasConcept C67705224 @default.
• W2040557851 hasConcept C86803240 @default.
• W2040557851 hasConceptScore W2040557851C104317684 @default.
• W2040557851 hasConceptScore W2040557851C134459356 @default.
• W2040557851 hasConceptScore W2040557851C143065580 @default.
• W2040557851 hasConceptScore W2040557851C153957851 @default.
• W2040557851 hasConceptScore W2040557851C175114707 @default.
• W2040557851 hasConceptScore W2040557851C185581394 @default.
• W2040557851 hasConceptScore W2040557851C25602115 @default.
• W2040557851 hasConceptScore W2040557851C54355233 @default.
• W2040557851 hasConceptScore W2040557851C547475151 @default.
• W2040557851 hasConceptScore W2040557851C55493867 @default.
• W2040557851 hasConceptScore W2040557851C67705224 @default.
• W2040557851 hasConceptScore W2040557851C86803240 @default.
• W2040557851 hasIssue "21" @default.
• W2040557851 hasLocation W20405578511 @default.
• W2040557851 hasLocation W20405578512 @default.
• W2040557851 hasLocation W20405578513 @default.
• W2040557851 hasLocation W20405578514 @default.
• W2040557851 hasOpenAccess W2040557851 @default.
• W2040557851 hasPrimaryLocation W20405578511 @default.
• W2040557851 hasRelatedWork W1533751437 @default.
• W2040557851 hasRelatedWork W1982942059 @default.
• W2040557851 hasRelatedWork W1992205301 @default.
• W2040557851 hasRelatedWork W2008669354 @default.
• W2040557851 hasRelatedWork W2050130927 @default.
• W2040557851 hasRelatedWork W2058471224 @default.
• W2040557851 hasRelatedWork W2075810299 @default.
• W2040557851 hasRelatedWork W2117110650 @default.
• W2040557851 hasRelatedWork W2900615434 @default.
• W2040557851 hasRelatedWork W2974393139 @default.
• W2040557851 hasVolume "85" @default.
• W2040557851 isParatext "false" @default.

• next