FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040558323> ?p ?o ?g. }

• W2040558323 endingPage "1048" @default.
• W2040558323 startingPage "1037" @default.
• W2040558323 abstract "The neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was used to generate a dose-dependent cell death of dopaminergic nigral neurons in the C57Bl mouse. Mice were injected with a total cumulative dose of 150 mg/kg of MPTP delivered over five days and killed at different time points both during and after the toxin injections. Two independent histological methods were used to determine whether the dopaminergic nigral neurons died via an apoptotic mechanism. In situ end-labelling with terminal deoxynucleotidyl transferase was used on paraformaldehyde-fixed, serial, frozen sections to identify cells with double-stranded DNA breaks. Apoptotic cell death was found to be initiated within 72 h of the first injection of the neurotoxin and peaked 24 h after the final MPTP injection. The metachromatic fluorochrome, Acridine Orange, was used on alternate sections to provide structural confirmation of the nuclear chromatin “clumping” considered to be representative of apoptosis. Confocal laser imaging combined with deconvolution techniques was used to resolve the fluorescent signal emitted by the in situ Acridine Orange–DNA complexes. The number of Acridine Orange-stained nuclei demonstrating chromatin clumping was identical to that of the positive in situ end-labelled nuclei observed over a 25 day period. Based upon these two independent methods of assessing apoptosis in situ, we conclude that a 150 mg/kg dose of MPTP can elicit apoptotic cell death in nigral dopaminergic neurons of the C57Bl mouse." @default.
• W2040558323 created "2016-06-24" @default.
• W2040558323 creator A5000210550 @default.
• W2040558323 creator A5059134028 @default.
• W2040558323 date "1997-02-01" @default.
• W2040558323 modified "2023-10-02" @default.
• W2040558323 title "In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining" @default.
• W2040558323 cites W1489400525 @default.
• W2040558323 cites W1501452286 @default.
• W2040558323 cites W1571048910 @default.
• W2040558323 cites W1571251056 @default.
• W2040558323 cites W1589415602 @default.
• W2040558323 cites W1964230438 @default.
• W2040558323 cites W1967268953 @default.
• W2040558323 cites W1969728294 @default.
• W2040558323 cites W1971335269 @default.
• W2040558323 cites W1979176029 @default.
• W2040558323 cites W1981734759 @default.
• W2040558323 cites W1982784171 @default.
• W2040558323 cites W1996774271 @default.
• W2040558323 cites W2000269122 @default.
• W2040558323 cites W2004795292 @default.
• W2040558323 cites W2023211111 @default.
• W2040558323 cites W2026316042 @default.
• W2040558323 cites W2030536065 @default.
• W2040558323 cites W2033126835 @default.
• W2040558323 cites W2037437861 @default.
• W2040558323 cites W2039445898 @default.
• W2040558323 cites W2056365448 @default.
• W2040558323 cites W2066896539 @default.
• W2040558323 cites W2070950077 @default.
• W2040558323 cites W2072190564 @default.
• W2040558323 cites W2075356815 @default.
• W2040558323 cites W2077260129 @default.
• W2040558323 cites W2086455336 @default.
• W2040558323 cites W2088125401 @default.
• W2040558323 cites W2092808670 @default.
• W2040558323 cites W2093190259 @default.
• W2040558323 cites W2098712005 @default.
• W2040558323 cites W2101462909 @default.
• W2040558323 cites W2101575450 @default.
• W2040558323 cites W2131461587 @default.
• W2040558323 cites W2148911589 @default.
• W2040558323 cites W2150882718 @default.
• W2040558323 cites W2169622817 @default.
• W2040558323 cites W2173390200 @default.
• W2040558323 cites W2185419453 @default.
• W2040558323 cites W2396964508 @default.
• W2040558323 cites W2417383855 @default.
• W2040558323 cites W2490943270 @default.
• W2040558323 cites W2785193602 @default.
• W2040558323 cites W4211045864 @default.
• W2040558323 doi "https://doi.org/10.1016/s0306-4522(96)00545-3" @default.
• W2040558323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9130785" @default.
• W2040558323 hasPublicationYear "1997" @default.
• W2040558323 type Work @default.
• W2040558323 sameAs 2040558323 @default.
• W2040558323 citedByCount "434" @default.
• W2040558323 countsByYear W20405583232012 @default.
• W2040558323 countsByYear W20405583232013 @default.
• W2040558323 countsByYear W20405583232014 @default.
• W2040558323 countsByYear W20405583232015 @default.
• W2040558323 countsByYear W20405583232016 @default.
• W2040558323 countsByYear W20405583232017 @default.
• W2040558323 countsByYear W20405583232018 @default.
• W2040558323 countsByYear W20405583232019 @default.
• W2040558323 countsByYear W20405583232020 @default.
• W2040558323 countsByYear W20405583232021 @default.
• W2040558323 countsByYear W20405583232022 @default.
• W2040558323 countsByYear W20405583232023 @default.
• W2040558323 crossrefType "journal-article" @default.
• W2040558323 hasAuthorship W2040558323A5000210550 @default.
• W2040558323 hasAuthorship W2040558323A5059134028 @default.
• W2040558323 hasConcept C134018914 @default.
• W2040558323 hasConcept C137183658 @default.
• W2040558323 hasConcept C153911025 @default.
• W2040558323 hasConcept C154113507 @default.
• W2040558323 hasConcept C185592680 @default.
• W2040558323 hasConcept C190283241 @default.
• W2040558323 hasConcept C196795494 @default.
• W2040558323 hasConcept C2776773494 @default.
• W2040558323 hasConcept C2778674702 @default.
• W2040558323 hasConcept C2779102032 @default.
• W2040558323 hasConcept C2780358027 @default.
• W2040558323 hasConcept C2780938664 @default.
• W2040558323 hasConcept C31573885 @default.
• W2040558323 hasConcept C513476851 @default.
• W2040558323 hasConcept C55493867 @default.
• W2040558323 hasConcept C86803240 @default.
• W2040558323 hasConceptScore W2040558323C134018914 @default.
• W2040558323 hasConceptScore W2040558323C137183658 @default.
• W2040558323 hasConceptScore W2040558323C153911025 @default.
• W2040558323 hasConceptScore W2040558323C154113507 @default.
• W2040558323 hasConceptScore W2040558323C185592680 @default.
• W2040558323 hasConceptScore W2040558323C190283241 @default.
• W2040558323 hasConceptScore W2040558323C196795494 @default.
• W2040558323 hasConceptScore W2040558323C2776773494 @default.
• W2040558323 hasConceptScore W2040558323C2778674702 @default.

• next