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- W2040558788 abstract "Abstract The effect of increased oxygen pressure on cortical GABA metabolism was investigated. Increased oxygen pressure decreased cortical GABA, GAD, and glutamate, and increased glutamine. Marked increases in cortical GABA over controls were found in mice pretreated with gabaculine, a specific GABA-T inhibitor, and exposed to either 4% or 100% of 6 atm of oxygen. The increase appears to be a pressure effect. Gabaculine failed to protect mice from oxygen convulsions although brain GABA was increased approximately 200%. Disulfiram, protective against oxygen convulsions did not prevent the oxygen-induced decrease in cortical GAD and GABA. The decrease in GABA by oxygen appears to be due to the inhibition of GAD." @default.
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- W2040558788 date "1980-01-01" @default.
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- W2040558788 title "GABA metabolism in O2-induced convulsions" @default.
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- W2040558788 doi "https://doi.org/10.1016/0361-9230(80)90131-8" @default.
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