FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040559106> ?p ?o ?g. }

• W2040559106 endingPage "G1226" @default.
• W2040559106 startingPage "G1220" @default.
• W2040559106 abstract "Platelet-activating factor (PAF) is a potent endogenous mediator of bowel inflammation. It activates neutrophils that are needed to initiate the inflammatory response. Macrophage inflammatory protein-2 (MIP-2), a critical C-X-C chemokine secreted by macrophages and epithelial cells, is a potent chemoattractant for neutrophils. Whereas MIP-2 has been previously shown to mediate the injury in various organs, its role in acute intestinal injury has never been assessed. In this study, we first investigated the effect of PAF on MIP-2 expression in the intestine. Anesthetized young adult male Sprague-Dawley rats were injected intravenously with either PAF (1.5 microg/kg) or saline. Sixty minutes later, ileal MIP-2 gene expression was determined by semiquantitative RT-PCR, and plasma and ileal MIP-2 protein was determined by ELISA. In a second step, we assessed the role of MIP-2 in PAF-induced bowel injury. Rats were pretreated with rabbit anti-rat MIP-2 antibodies or control IgG for 90 min and then injected intravenously with PAF (2.5 microg/kg) for 90 min. We found that, in the rat intestine, 1) MIP-2 mRNA was only minimally expressed constitutively in sham-operated animals; 2) MIP-2 mRNA was significantly upregulated in response to PAF; 3) MIP-2 protein plasma levels and local production of MIP-2 in the ileum were markedly induced by PAF; 4) the administration of anti-rat MIP-2 IgG, but not control rabbit IgG, markedly reduced PAF-induced bowel injury (injury scores of 0.19 +/- 0.09 vs. 1.12 +/- 0.43, P < 0.05), hypotension, and leukopenia but did not reduce PAF-induced hemoconcentration. Thus we conclude that MIP-2 mediates PAF-induced intestinal injury." @default.
• W2040559106 created "2016-06-24" @default.
• W2040559106 creator A5013007732 @default.
• W2040559106 creator A5023105822 @default.
• W2040559106 creator A5067739110 @default.
• W2040559106 creator A5083043424 @default.
• W2040559106 date "2004-12-01" @default.
• W2040559106 modified "2023-10-14" @default.
• W2040559106 title "Macrophage inflammatory protein-2 mediates the bowel injury induced by platelet-activating factor" @default.
• W2040559106 cites W1520762000 @default.
• W2040559106 cites W1558872044 @default.
• W2040559106 cites W1584362946 @default.
• W2040559106 cites W1603333528 @default.
• W2040559106 cites W1606386817 @default.
• W2040559106 cites W1634308456 @default.
• W2040559106 cites W1967979007 @default.
• W2040559106 cites W1979382115 @default.
• W2040559106 cites W1988742153 @default.
• W2040559106 cites W1991812740 @default.
• W2040559106 cites W1999797629 @default.
• W2040559106 cites W2013899978 @default.
• W2040559106 cites W2017390338 @default.
• W2040559106 cites W2034891814 @default.
• W2040559106 cites W2036156531 @default.
• W2040559106 cites W2046875107 @default.
• W2040559106 cites W2053223154 @default.
• W2040559106 cites W2053809451 @default.
• W2040559106 cites W2056924037 @default.
• W2040559106 cites W206604000 @default.
• W2040559106 cites W2076565680 @default.
• W2040559106 cites W2082566019 @default.
• W2040559106 cites W2082650560 @default.
• W2040559106 cites W2085589135 @default.
• W2040559106 cites W2108643952 @default.
• W2040559106 cites W2109676094 @default.
• W2040559106 cites W2118788387 @default.
• W2040559106 cites W2118940695 @default.
• W2040559106 cites W2122081106 @default.
• W2040559106 cites W2138694854 @default.
• W2040559106 cites W2142921942 @default.
• W2040559106 cites W2144451129 @default.
• W2040559106 cites W2150188762 @default.
• W2040559106 cites W2150396060 @default.
• W2040559106 cites W2154188931 @default.
• W2040559106 cites W2156829792 @default.
• W2040559106 cites W2164381397 @default.
• W2040559106 cites W2220683143 @default.
• W2040559106 cites W2275884641 @default.
• W2040559106 cites W4313331340 @default.
• W2040559106 doi "https://doi.org/10.1152/ajpgi.00231.2004" @default.
• W2040559106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15319184" @default.
• W2040559106 hasPublicationYear "2004" @default.
• W2040559106 type Work @default.
• W2040559106 sameAs 2040559106 @default.
• W2040559106 citedByCount "24" @default.
• W2040559106 countsByYear W20405591062012 @default.
• W2040559106 countsByYear W20405591062013 @default.
• W2040559106 countsByYear W20405591062014 @default.
• W2040559106 countsByYear W20405591062015 @default.
• W2040559106 countsByYear W20405591062018 @default.
• W2040559106 crossrefType "journal-article" @default.
• W2040559106 hasAuthorship W2040559106A5013007732 @default.
• W2040559106 hasAuthorship W2040559106A5023105822 @default.
• W2040559106 hasAuthorship W2040559106A5067739110 @default.
• W2040559106 hasAuthorship W2040559106A5083043424 @default.
• W2040559106 hasConcept C126322002 @default.
• W2040559106 hasConcept C13373296 @default.
• W2040559106 hasConcept C134018914 @default.
• W2040559106 hasConcept C16613235 @default.
• W2040559106 hasConcept C170217031 @default.
• W2040559106 hasConcept C185592680 @default.
• W2040559106 hasConcept C202751555 @default.
• W2040559106 hasConcept C203014093 @default.
• W2040559106 hasConcept C2776914184 @default.
• W2040559106 hasConcept C2777226302 @default.
• W2040559106 hasConcept C2779020240 @default.
• W2040559106 hasConcept C2779244956 @default.
• W2040559106 hasConcept C55493867 @default.
• W2040559106 hasConcept C71924100 @default.
• W2040559106 hasConcept C98274493 @default.
• W2040559106 hasConceptScore W2040559106C126322002 @default.
• W2040559106 hasConceptScore W2040559106C13373296 @default.
• W2040559106 hasConceptScore W2040559106C134018914 @default.
• W2040559106 hasConceptScore W2040559106C16613235 @default.
• W2040559106 hasConceptScore W2040559106C170217031 @default.
• W2040559106 hasConceptScore W2040559106C185592680 @default.
• W2040559106 hasConceptScore W2040559106C202751555 @default.
• W2040559106 hasConceptScore W2040559106C203014093 @default.
• W2040559106 hasConceptScore W2040559106C2776914184 @default.
• W2040559106 hasConceptScore W2040559106C2777226302 @default.
• W2040559106 hasConceptScore W2040559106C2779020240 @default.
• W2040559106 hasConceptScore W2040559106C2779244956 @default.
• W2040559106 hasConceptScore W2040559106C55493867 @default.
• W2040559106 hasConceptScore W2040559106C71924100 @default.
• W2040559106 hasConceptScore W2040559106C98274493 @default.
• W2040559106 hasIssue "6" @default.
• W2040559106 hasLocation W20405591061 @default.
• W2040559106 hasLocation W20405591062 @default.

• next