FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040559929> ?p ?o ?g. }

• W2040559929 endingPage "504" @default.
• W2040559929 startingPage "499" @default.
• W2040559929 abstract "The purpose of this study was to compare the short-term efficacy and safety of risperidone and clozapine in treatment-resistant chronic schizophrenic patients.In a controlled double-blind, multicenter study, 86 inpatients with chronic schizophrenia (DSM-III-R), who were resistant to or intolerant of conventional neuroleptics, were randomly assigned to receive risperidone or clozapine for 8 weeks after a 7-day washout period. After a 1-week dose-titration phase, doses were fixed at 6 mg/day of risperidone and 300 mg/day of clozapine for 1 week and then adjusted according to each patient's response. The final mean doses were 6.4 mg/day of risperidone and 291.2 mg/day of clozapine. Treatment efficacy and safety were evaluated with several well-known rating scales.Both risperidone and clozapine significantly reduced the severity of psychotic symptoms (scores on the Positive and Negative Syndrome Scale and the Clinical Global Impression scale) from baseline, with no significant between-group differences. At endpoint, 67% of the risperidone group and 65% of the clozapine group were clinically improved (reduction of 20% or more in total Positive and Negative Syndrome Scale score). Risperidone appeared to have a faster onset of action. In both groups extrapyramidal symptoms and other adverse events were few, and their severity was generally mild. Neither group showed evidence of a relation between drug plasma concentrations and clinical effectiveness.Risperidone was well tolerated and as effective as medium doses of clozapine in patients with chronic schizophrenia who had been resistant to or intolerant of conventional neuroleptics." @default.
• W2040559929 created "2016-06-24" @default.
• W2040559929 creator A5030437485 @default.
• W2040559929 creator A5041764955 @default.
• W2040559929 creator A5042324353 @default.
• W2040559929 creator A5051605080 @default.
• W2040559929 creator A5073250901 @default.
• W2040559929 creator A5074078576 @default.
• W2040559929 creator A5083342797 @default.
• W2040559929 date "1998-04-01" @default.
• W2040559929 modified "2023-09-26" @default.
• W2040559929 title "Risperidone Versus Clozapine in Treatment-Resistant Chronic Schizophrenia: A Randomized Double-Blind Study" @default.
• W2040559929 cites W153750880 @default.
• W2040559929 cites W1579155080 @default.
• W2040559929 cites W1668835600 @default.
• W2040559929 cites W1962369723 @default.
• W2040559929 cites W1964688493 @default.
• W2040559929 cites W1976325341 @default.
• W2040559929 cites W1979300931 @default.
• W2040559929 cites W1988457299 @default.
• W2040559929 cites W1990712459 @default.
• W2040559929 cites W2018434135 @default.
• W2040559929 cites W2019373089 @default.
• W2040559929 cites W2037124948 @default.
• W2040559929 cites W2039548722 @default.
• W2040559929 cites W2040538157 @default.
• W2040559929 cites W2046837647 @default.
• W2040559929 cites W2062210283 @default.
• W2040559929 cites W2065748094 @default.
• W2040559929 cites W2067523973 @default.
• W2040559929 cites W2075321548 @default.
• W2040559929 cites W2085360366 @default.
• W2040559929 cites W2088879645 @default.
• W2040559929 cites W2098644261 @default.
• W2040559929 cites W2100828552 @default.
• W2040559929 cites W2106051200 @default.
• W2040559929 cites W2120106329 @default.
• W2040559929 cites W2146438680 @default.
• W2040559929 cites W2159165479 @default.
• W2040559929 cites W2324890768 @default.
• W2040559929 cites W2333258705 @default.
• W2040559929 cites W2410837287 @default.
• W2040559929 cites W2415246766 @default.
• W2040559929 cites W2416853676 @default.
• W2040559929 cites W3027376247 @default.
• W2040559929 cites W36634213 @default.
• W2040559929 cites W45673975 @default.
• W2040559929 cites W59918674 @default.
• W2040559929 cites W940697911 @default.
• W2040559929 doi "https://doi.org/10.1176/ajp.155.4.499" @default.
• W2040559929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9545995" @default.
• W2040559929 hasPublicationYear "1998" @default.
• W2040559929 type Work @default.
• W2040559929 sameAs 2040559929 @default.
• W2040559929 citedByCount "239" @default.
• W2040559929 countsByYear W20405599292012 @default.
• W2040559929 countsByYear W20405599292013 @default.
• W2040559929 countsByYear W20405599292014 @default.
• W2040559929 countsByYear W20405599292015 @default.
• W2040559929 countsByYear W20405599292016 @default.
• W2040559929 countsByYear W20405599292017 @default.
• W2040559929 countsByYear W20405599292018 @default.
• W2040559929 countsByYear W20405599292019 @default.
• W2040559929 countsByYear W20405599292020 @default.
• W2040559929 countsByYear W20405599292021 @default.
• W2040559929 countsByYear W20405599292022 @default.
• W2040559929 countsByYear W20405599292023 @default.
• W2040559929 crossrefType "journal-article" @default.
• W2040559929 hasAuthorship W2040559929A5030437485 @default.
• W2040559929 hasAuthorship W2040559929A5041764955 @default.
• W2040559929 hasAuthorship W2040559929A5042324353 @default.
• W2040559929 hasAuthorship W2040559929A5051605080 @default.
• W2040559929 hasAuthorship W2040559929A5073250901 @default.
• W2040559929 hasAuthorship W2040559929A5074078576 @default.
• W2040559929 hasAuthorship W2040559929A5083342797 @default.
• W2040559929 hasConcept C118552586 @default.
• W2040559929 hasConcept C126322002 @default.
• W2040559929 hasConcept C142724271 @default.
• W2040559929 hasConcept C15744967 @default.
• W2040559929 hasConcept C197934379 @default.
• W2040559929 hasConcept C204787440 @default.
• W2040559929 hasConcept C27081682 @default.
• W2040559929 hasConcept C2776000289 @default.
• W2040559929 hasConcept C2776412080 @default.
• W2040559929 hasConcept C2778528637 @default.
• W2040559929 hasConcept C2779727114 @default.
• W2040559929 hasConcept C2780057945 @default.
• W2040559929 hasConcept C2780135775 @default.
• W2040559929 hasConcept C2780494398 @default.
• W2040559929 hasConcept C2780616385 @default.
• W2040559929 hasConcept C2780864610 @default.
• W2040559929 hasConcept C2780948584 @default.
• W2040559929 hasConcept C2781353949 @default.
• W2040559929 hasConcept C42219234 @default.
• W2040559929 hasConcept C513476851 @default.
• W2040559929 hasConcept C71924100 @default.
• W2040559929 hasConceptScore W2040559929C118552586 @default.
• W2040559929 hasConceptScore W2040559929C126322002 @default.

• next