Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040562810> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2040562810 endingPage "164" @default.
- W2040562810 startingPage "160" @default.
- W2040562810 abstract "The intracellular parasite Toxoplasma gondii is thought to disseminate throughout the host by circulation of tachyzoite-infected leukocytes in the blood, and adherence and migration of such leukocytes into solid tissues. However, it is unclear whether T. gondii-infected leukocytes can migrate to solid organs via the general circulation. In this study, we developed a real-time quantitative PCR (qRT-PCR) method to determine the rate of infection of peripheral blood mononuclear cells (PBMCs) flowing into and remaining within solid organs in mice. A transgenic T. gondii parasite line derived from the PLK strain that expresses DsRed Express, and transgenic green fluorescent protein-positive PBMCs, were used for these experiments. Tachyzoite-infected PBMCs were injected into mouse tail veins and qRT-PCR was used to measure the infection rates of the PBMCs remaining in the lungs, liver, spleen and brain. We found that the PBMCs in the lungs and liver had statistically higher infection rates than that of the original inoculum; this difference was statistically significant. However, the PBMC infection rate in the spleen showed no such enhancement. These results show that tachyzoite-infected PBMCs in the general circulation remain in the lungs and liver more effectively than non-infected PBMCs." @default.
- W2040562810 created "2016-06-24" @default.
- W2040562810 creator A5005402130 @default.
- W2040562810 creator A5035423231 @default.
- W2040562810 creator A5037435382 @default.
- W2040562810 creator A5047014977 @default.
- W2040562810 creator A5049541171 @default.
- W2040562810 creator A5058839064 @default.
- W2040562810 creator A5073830052 @default.
- W2040562810 date "2013-06-01" @default.
- W2040562810 modified "2023-10-18" @default.
- W2040562810 title "Toxoplasma gondii tachyzoite-infected peripheral blood mononuclear cells are enriched in mouse lungs and liver" @default.
- W2040562810 cites W1974405068 @default.
- W2040562810 cites W2000156766 @default.
- W2040562810 cites W2017016428 @default.
- W2040562810 cites W2049092587 @default.
- W2040562810 cites W2061582332 @default.
- W2040562810 cites W2080457342 @default.
- W2040562810 cites W2092262380 @default.
- W2040562810 cites W2093473658 @default.
- W2040562810 cites W2111146118 @default.
- W2040562810 doi "https://doi.org/10.1016/j.exppara.2013.03.006" @default.
- W2040562810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23538031" @default.
- W2040562810 hasPublicationYear "2013" @default.
- W2040562810 type Work @default.
- W2040562810 sameAs 2040562810 @default.
- W2040562810 citedByCount "21" @default.
- W2040562810 countsByYear W20405628102013 @default.
- W2040562810 countsByYear W20405628102014 @default.
- W2040562810 countsByYear W20405628102015 @default.
- W2040562810 countsByYear W20405628102016 @default.
- W2040562810 countsByYear W20405628102017 @default.
- W2040562810 countsByYear W20405628102018 @default.
- W2040562810 countsByYear W20405628102019 @default.
- W2040562810 countsByYear W20405628102020 @default.
- W2040562810 countsByYear W20405628102021 @default.
- W2040562810 countsByYear W20405628102022 @default.
- W2040562810 countsByYear W20405628102023 @default.
- W2040562810 crossrefType "journal-article" @default.
- W2040562810 hasAuthorship W2040562810A5005402130 @default.
- W2040562810 hasAuthorship W2040562810A5035423231 @default.
- W2040562810 hasAuthorship W2040562810A5037435382 @default.
- W2040562810 hasAuthorship W2040562810A5047014977 @default.
- W2040562810 hasAuthorship W2040562810A5049541171 @default.
- W2040562810 hasAuthorship W2040562810A5058839064 @default.
- W2040562810 hasAuthorship W2040562810A5073830052 @default.
- W2040562810 hasConcept C102230213 @default.
- W2040562810 hasConcept C104317684 @default.
- W2040562810 hasConcept C136764020 @default.
- W2040562810 hasConcept C137061746 @default.
- W2040562810 hasConcept C141035611 @default.
- W2040562810 hasConcept C159047783 @default.
- W2040562810 hasConcept C159654299 @default.
- W2040562810 hasConcept C202751555 @default.
- W2040562810 hasConcept C203014093 @default.
- W2040562810 hasConcept C2778128430 @default.
- W2040562810 hasConcept C2780931953 @default.
- W2040562810 hasConcept C41008148 @default.
- W2040562810 hasConcept C55493867 @default.
- W2040562810 hasConcept C71928629 @default.
- W2040562810 hasConcept C86803240 @default.
- W2040562810 hasConceptScore W2040562810C102230213 @default.
- W2040562810 hasConceptScore W2040562810C104317684 @default.
- W2040562810 hasConceptScore W2040562810C136764020 @default.
- W2040562810 hasConceptScore W2040562810C137061746 @default.
- W2040562810 hasConceptScore W2040562810C141035611 @default.
- W2040562810 hasConceptScore W2040562810C159047783 @default.
- W2040562810 hasConceptScore W2040562810C159654299 @default.
- W2040562810 hasConceptScore W2040562810C202751555 @default.
- W2040562810 hasConceptScore W2040562810C203014093 @default.
- W2040562810 hasConceptScore W2040562810C2778128430 @default.
- W2040562810 hasConceptScore W2040562810C2780931953 @default.
- W2040562810 hasConceptScore W2040562810C41008148 @default.
- W2040562810 hasConceptScore W2040562810C55493867 @default.
- W2040562810 hasConceptScore W2040562810C71928629 @default.
- W2040562810 hasConceptScore W2040562810C86803240 @default.
- W2040562810 hasFunder F4320320912 @default.
- W2040562810 hasIssue "2" @default.
- W2040562810 hasLocation W20405628101 @default.
- W2040562810 hasLocation W20405628102 @default.
- W2040562810 hasOpenAccess W2040562810 @default.
- W2040562810 hasPrimaryLocation W20405628101 @default.
- W2040562810 hasRelatedWork W1519724357 @default.
- W2040562810 hasRelatedWork W1568221046 @default.
- W2040562810 hasRelatedWork W1967728126 @default.
- W2040562810 hasRelatedWork W2017250641 @default.
- W2040562810 hasRelatedWork W2040562810 @default.
- W2040562810 hasRelatedWork W2071857583 @default.
- W2040562810 hasRelatedWork W2078363838 @default.
- W2040562810 hasRelatedWork W2324429495 @default.
- W2040562810 hasRelatedWork W2987826785 @default.
- W2040562810 hasRelatedWork W3175408503 @default.
- W2040562810 hasVolume "134" @default.
- W2040562810 isParatext "false" @default.
- W2040562810 isRetracted "false" @default.
- W2040562810 magId "2040562810" @default.
- W2040562810 workType "article" @default.