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- W2040566730 abstract "In this issue of<i>JAMA</i>, Buyse and colleagues<sup>1</sup>present a meta-analysis of adjuvant therapy for colorectal cancer. They have previously provided information about meta-analysis,<sup>2</sup>which is a new discipline that statistically combines and critically reviews the results of previous research. The purposes of meta-analysis include the following: (1) to increase statistical power for primary end points and for subgroups, (2) to resolve uncertainty when reports disagree, (3) to improve estimates of effect size, and (4) to raise and possibly answer questions not posed at the start of individual trials. In this comprehensive review, Buyse and coworkers<sup>1</sup>have assembled all randomized, controlled, clinical trials on adjuvant therapy for colorectal cancer published up to December 1986 in the English language. They excluded nonrandomized and immature trials and those using adjuvant liver perfusion. Among the 27 trials found, eight trials compared radio See also p 3571. therapy with (surgical) control" @default.
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- W2040566730 date "1988-06-24" @default.
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- W2040566730 title "Colorectal Cancer Chemotherapy: Meta-analysis or Large-Scale Trials?" @default.
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- W2040566730 doi "https://doi.org/10.1001/jama.1988.03720240073039" @default.
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