FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040569483> ?p ?o ?g. }

• W2040569483 endingPage "252" @default.
• W2040569483 startingPage "246" @default.
• W2040569483 abstract "The molecular basis of the beneficial effects associated with exercise training (ET) on overall ventricular function (VF) in heart failure (HF) remains unclear. We investigated potential Ca 2+ handling abnormalities and whether ET would improve VF of mice lacking α 2A - and α 2C -adrenoceptors (α 2A /α 2C ARKO) that have sympathetic hyperactivity-induced HF. A cohort of male wild-type (WT) and congenic α 2A /α 2C ARKO mice in a C57BL/J genetic background (5–7 mo of age) was randomly assigned into untrained and trained groups. VF was assessed by two-dimensional guided M-mode echocardiography. Cardiac myocyte width and ventricular fibrosis were evaluated with a computer-assisted morphometric system. Sarcoplasmic reticulum Ca 2+ ATPase (SERCA2), phospholamban (PLN), phospho-Ser 16 -PLN, phospho-Thr 17 -PLN, phosphatase 1 (PP1), and Na + -Ca 2+ exchanger (NCX) were analyzed by Western blotting. ET consisted of 8-wk running sessions of 60 min, 5 days/wk. α 2A /α 2C ARKO mice displayed exercise intolerance, systolic dysfunction, increased cardiac myocyte width, and ventricular fibrosis paralleled by decreased SERCA2 and increased NCX expression levels. ET in α 2A /α 2C ARKO mice improved exercise tolerance and systolic function. ET slightly reduced cardiac myocyte width, but unchanged ventricular fibrosis in α 2A /α 2C ARKO mice. ET significantly increased the expression of SERCA2 (20%) and phospho-Ser 16 -PLN (63%), phospho-Thr 17 -PLN (211%) in α 2A /α 2C ARKO mice. Furthermore, ET restored NCX and PP1 expression in α 2A /α 2C ARKO to untrained WT mice levels. Thus, we provide evidence that Ca 2+ handling is impaired in this HF model and that overall VF improved upon ET, which was associated to changes in the net balance of cardiac Ca 2+ handling proteins." @default.
• W2040569483 created "2016-06-24" @default.
• W2040569483 creator A5011567977 @default.
• W2040569483 creator A5017921195 @default.
• W2040569483 creator A5041572754 @default.
• W2040569483 creator A5059888677 @default.
• W2040569483 creator A5068471576 @default.
• W2040569483 creator A5069859243 @default.
• W2040569483 creator A5075660717 @default.
• W2040569483 creator A5084503662 @default.
• W2040569483 creator A5088565799 @default.
• W2040569483 date "2007-05-01" @default.
• W2040569483 modified "2023-10-18" @default.
• W2040569483 title "Exercise training improves the net balance of cardiac Ca²⁺ handling protein expression in heart failure" @default.
• W2040569483 cites W1980272147 @default.
• W2040569483 cites W1980988188 @default.
• W2040569483 cites W1992345790 @default.
• W2040569483 cites W1993487853 @default.
• W2040569483 cites W2003790840 @default.
• W2040569483 cites W2006610059 @default.
• W2040569483 cites W2008716515 @default.
• W2040569483 cites W2009566289 @default.
• W2040569483 cites W2011128438 @default.
• W2040569483 cites W2017163269 @default.
• W2040569483 cites W2028256081 @default.
• W2040569483 cites W2030507367 @default.
• W2040569483 cites W2030858573 @default.
• W2040569483 cites W2031832454 @default.
• W2040569483 cites W2033328575 @default.
• W2040569483 cites W2034507492 @default.
• W2040569483 cites W2038596152 @default.
• W2040569483 cites W2042252166 @default.
• W2040569483 cites W2060638044 @default.
• W2040569483 cites W2066020583 @default.
• W2040569483 cites W2068671266 @default.
• W2040569483 cites W2070631962 @default.
• W2040569483 cites W2082823804 @default.
• W2040569483 cites W2088749722 @default.
• W2040569483 cites W2095778449 @default.
• W2040569483 cites W2096380667 @default.
• W2040569483 cites W2097102755 @default.
• W2040569483 cites W2124101879 @default.
• W2040569483 cites W2127952198 @default.
• W2040569483 cites W2138788769 @default.
• W2040569483 cites W2139091946 @default.
• W2040569483 cites W2144964986 @default.
• W2040569483 cites W2144975424 @default.
• W2040569483 cites W2146198755 @default.
• W2040569483 cites W2147372693 @default.
• W2040569483 cites W2151837141 @default.
• W2040569483 cites W2151912878 @default.
• W2040569483 cites W2159182796 @default.
• W2040569483 cites W2160986262 @default.
• W2040569483 cites W2197264447 @default.
• W2040569483 cites W94138424 @default.
• W2040569483 doi "https://doi.org/10.1152/physiolgenomics.00188.2006" @default.
• W2040569483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17244791" @default.
• W2040569483 hasPublicationYear "2007" @default.
• W2040569483 type Work @default.
• W2040569483 sameAs 2040569483 @default.
• W2040569483 citedByCount "100" @default.
• W2040569483 countsByYear W20405694832012 @default.
• W2040569483 countsByYear W20405694832013 @default.
• W2040569483 countsByYear W20405694832014 @default.
• W2040569483 countsByYear W20405694832015 @default.
• W2040569483 countsByYear W20405694832016 @default.
• W2040569483 countsByYear W20405694832017 @default.
• W2040569483 countsByYear W20405694832018 @default.
• W2040569483 countsByYear W20405694832019 @default.
• W2040569483 countsByYear W20405694832020 @default.
• W2040569483 countsByYear W20405694832021 @default.
• W2040569483 countsByYear W20405694832022 @default.
• W2040569483 countsByYear W20405694832023 @default.
• W2040569483 crossrefType "journal-article" @default.
• W2040569483 hasAuthorship W2040569483A5011567977 @default.
• W2040569483 hasAuthorship W2040569483A5017921195 @default.
• W2040569483 hasAuthorship W2040569483A5041572754 @default.
• W2040569483 hasAuthorship W2040569483A5059888677 @default.
• W2040569483 hasAuthorship W2040569483A5068471576 @default.
• W2040569483 hasAuthorship W2040569483A5069859243 @default.
• W2040569483 hasAuthorship W2040569483A5075660717 @default.
• W2040569483 hasAuthorship W2040569483A5084503662 @default.
• W2040569483 hasAuthorship W2040569483A5088565799 @default.
• W2040569483 hasConcept C111566952 @default.
• W2040569483 hasConcept C126322002 @default.
• W2040569483 hasConcept C134018914 @default.
• W2040569483 hasConcept C158617107 @default.
• W2040569483 hasConcept C164705383 @default.
• W2040569483 hasConcept C17137333 @default.
• W2040569483 hasConcept C207200792 @default.
• W2040569483 hasConcept C2777420927 @default.
• W2040569483 hasConcept C2778198053 @default.
• W2040569483 hasConcept C2778797674 @default.
• W2040569483 hasConcept C2780559512 @default.
• W2040569483 hasConcept C55493867 @default.
• W2040569483 hasConcept C71924100 @default.
• W2040569483 hasConcept C86803240 @default.
• W2040569483 hasConceptScore W2040569483C111566952 @default.

• next