FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040572942> ?p ?o ?g. }

• W2040572942 endingPage "226" @default.
• W2040572942 startingPage "215" @default.
• W2040572942 abstract "On the basis of clinical, histological and bacteriological assessments, 31 patients in Central India were selected and classified as having active but early lepromatous leprosy and 4 patients as having early borderline leprosy. From the nose of each patient an average of 4 biopsies were taken from particular sites of the septum and turbinates either by punch biopsy or dissection with a scalpel. The nasal tissues from all the lepromatous patients contained many acid-fast bacilli; no bacilli or abnormalities were seen in nasal tissues from the borderline patients. The histopathology of these highly bacilliferous tissues is described. Bacilli were universally seen in macrophages, but they were also seen in blood monocytes and polymorphs, fibroblasts, squamous and pseudo-columnar epithelium, keratin, peri- and endo-neurial cells of tiny nerve bundles, erectile tissue, vascular plain muscle, perivascular histiocytes and frequently and abundantly in the cytoplasm of endothelial lining cells of lymphatics and of small blood vessels and free within the lumina of these vessels. Five basic mechanisms of escape of bacilli from the submucosa on to the surface, and thus into the external environment, are described. Secondary infection, in the presence of an expansile lepromatous infiltrate, together with simple trauma to the surface epithelium, are the main factors in the discharge of bacilli. These histopathological observations are consistent with the findings from other recent studies on the nose in leprosy regarding (1) the large numbers of morphologically intact and viable Myco. leprae excreted in the nasal mucus of lepromatous patients; (2) the clinical changes observed in the nose of such patients, and (3) the similar nasal involvement and excretion of Myco. leprae from the nose of mice inoculated with leprosy bacilli of human origin. Of particular interest was the frequency and intensity of bacilli within the endothelial lining cells of small blood and lymph vessels and the presence of bacilli free within the lumina of these vessels or within monocytes and polymorphs. The possible dynamic significance of these observations in the pathogenesis of leprosy is discussed. The significance of all these observations in relation to (1) the spread of leprosy; (2) local factors in the nose which might favour the growth of Myco. leprae, and (3) the nose as a portal of entry, are discussed." @default.
• W2040572942 created "2016-06-24" @default.
• W2040572942 creator A5045088969 @default.
• W2040572942 creator A5057842560 @default.
• W2040572942 creator A5072198857 @default.
• W2040572942 creator A5072992497 @default.
• W2040572942 date "1975-04-01" @default.
• W2040572942 modified "2023-09-30" @default.
• W2040572942 title "The histopathology of lepromatous leprosy tn the nose" @default.
• W2040572942 cites W1537077061 @default.
• W2040572942 cites W1626718189 @default.
• W2040572942 cites W1974941600 @default.
• W2040572942 cites W1986236299 @default.
• W2040572942 cites W204743729 @default.
• W2040572942 cites W2098809527 @default.
• W2040572942 cites W2152939207 @default.
• W2040572942 cites W2262751336 @default.
• W2040572942 cites W2269908385 @default.
• W2040572942 cites W2323275294 @default.
• W2040572942 cites W2406923638 @default.
• W2040572942 cites W2559321687 @default.
• W2040572942 cites W3163250050 @default.
• W2040572942 doi "https://doi.org/10.1002/path.1711150406" @default.
• W2040572942 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1099180" @default.
• W2040572942 hasPublicationYear "1975" @default.
• W2040572942 type Work @default.
• W2040572942 sameAs 2040572942 @default.
• W2040572942 citedByCount "40" @default.
• W2040572942 countsByYear W20405729422012 @default.
• W2040572942 countsByYear W20405729422013 @default.
• W2040572942 countsByYear W20405729422015 @default.
• W2040572942 countsByYear W20405729422018 @default.
• W2040572942 countsByYear W20405729422019 @default.
• W2040572942 countsByYear W20405729422021 @default.
• W2040572942 countsByYear W20405729422022 @default.
• W2040572942 crossrefType "journal-article" @default.
• W2040572942 hasAuthorship W2040572942A5045088969 @default.
• W2040572942 hasAuthorship W2040572942A5057842560 @default.
• W2040572942 hasAuthorship W2040572942A5072198857 @default.
• W2040572942 hasAuthorship W2040572942A5072992497 @default.
• W2040572942 hasConcept C105702510 @default.
• W2040572942 hasConcept C142724271 @default.
• W2040572942 hasConcept C2775934546 @default.
• W2040572942 hasConcept C2776870249 @default.
• W2040572942 hasConcept C2777917003 @default.
• W2040572942 hasConcept C2778311950 @default.
• W2040572942 hasConcept C2779052585 @default.
• W2040572942 hasConcept C2779823659 @default.
• W2040572942 hasConcept C2779846462 @default.
• W2040572942 hasConcept C2780695269 @default.
• W2040572942 hasConcept C43100952 @default.
• W2040572942 hasConcept C523546767 @default.
• W2040572942 hasConcept C54355233 @default.
• W2040572942 hasConcept C544855455 @default.
• W2040572942 hasConcept C71924100 @default.
• W2040572942 hasConcept C86803240 @default.
• W2040572942 hasConceptScore W2040572942C105702510 @default.
• W2040572942 hasConceptScore W2040572942C142724271 @default.
• W2040572942 hasConceptScore W2040572942C2775934546 @default.
• W2040572942 hasConceptScore W2040572942C2776870249 @default.
• W2040572942 hasConceptScore W2040572942C2777917003 @default.
• W2040572942 hasConceptScore W2040572942C2778311950 @default.
• W2040572942 hasConceptScore W2040572942C2779052585 @default.
• W2040572942 hasConceptScore W2040572942C2779823659 @default.
• W2040572942 hasConceptScore W2040572942C2779846462 @default.
• W2040572942 hasConceptScore W2040572942C2780695269 @default.
• W2040572942 hasConceptScore W2040572942C43100952 @default.
• W2040572942 hasConceptScore W2040572942C523546767 @default.
• W2040572942 hasConceptScore W2040572942C54355233 @default.
• W2040572942 hasConceptScore W2040572942C544855455 @default.
• W2040572942 hasConceptScore W2040572942C71924100 @default.
• W2040572942 hasConceptScore W2040572942C86803240 @default.
• W2040572942 hasIssue "4" @default.
• W2040572942 hasLocation W20405729421 @default.
• W2040572942 hasLocation W20405729422 @default.
• W2040572942 hasOpenAccess W2040572942 @default.
• W2040572942 hasPrimaryLocation W20405729421 @default.
• W2040572942 hasRelatedWork W1978558977 @default.
• W2040572942 hasRelatedWork W2040572942 @default.
• W2040572942 hasRelatedWork W2050943005 @default.
• W2040572942 hasRelatedWork W2071196300 @default.
• W2040572942 hasRelatedWork W2199911105 @default.
• W2040572942 hasRelatedWork W2416834899 @default.
• W2040572942 hasRelatedWork W2418151544 @default.
• W2040572942 hasRelatedWork W2440671308 @default.
• W2040572942 hasRelatedWork W41285360 @default.
• W2040572942 hasRelatedWork W4296391670 @default.
• W2040572942 hasVolume "115" @default.
• W2040572942 isParatext "false" @default.
• W2040572942 isRetracted "false" @default.
• W2040572942 magId "2040572942" @default.
• W2040572942 workType "article" @default.