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- W2040573105 abstract "RATIONALE: One objective of controller therapy in patients with persistent asthma is to minimize the use of relief medication (RM). When patients exchange one controller treatment for another, it is important for the new therapy to maintain or improve control as measured by RM use. Inhaled mometasone furoate (MF) was evaluated in 3 randomized placebo-controlled trials in children aged 4-11 years with mild persistent asthma previously maintained on inhaled corticosteroids (ICSs). The effects of MF versus placebo on daily use of RM over time were evaluated. METHODS: Data from three phase III studies were pooled for analysis of the effects of MF 110μg/d and 220μg/d (n=629) vs placebo (n=271) on RM use (puffs/d) over a 12-week study period. ANCOVA examined RM use changes from baseline weekly and at endpoint within groups and for MF vs placebo comparisons. RESULTS: Use of RM decreased significantly from baseline for MF groups over all 12 study weeks and at endpoint (range -0.25 to -0.57 puffs/d; P<0.01). Significantly greater reductions in RM use for MF 110μg/d vs placebo (range, -0.29 to -0.50 puffs/d) were evident at weeks 29 (P<0.023) and endpoint (P=0.0003). Significantly greater reductions in RM use for MF 220μg/d vs placebo (range, -0.33 to -0.63 puffs/d) were evident at weeks 2-11 (P<0.014) and endpoint (P<0.0001). CONCLUSIONS: Decreased RM use following MF treatment was maintained over time and at study completion. MF improved asthma control compared with placebo, as indicated by significant reductions of RM use in children with mild persistent asthma who were previously receiving other ICSs." @default.
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- W2040573105 date "2010-02-01" @default.
- W2040573105 modified "2023-09-27" @default.
- W2040573105 title "Reduction of Relief Medication Use in Children Receiving Inhaled Mometasone Furoate for Control of Mild Persistent Asthma" @default.
- W2040573105 doi "https://doi.org/10.1016/j.jaci.2009.12.764" @default.
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