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• W2040574003 abstract "Fibroblasts are major cellular components of healing wounds. In this regard, it remains to be fully understood how different paracrine signals may influence the final collagen/matrix metalloproteinase (MMP) balance in resident fibroblasts. Our previous reports have demonstrated that circulating stem cells and monocytes can be transdifferentiated into keratinocyte-like cells under certain culture conditions. These transformed cells are able to stimulate MMP-1 expression in dermal fibroblasts. However, the underlying mechanism of this cell-to-cell interaction is unknown. This study describes exosomes as a major delivery system that keratinocyte-like cells use to release proteins into the conditioned media. The exosomes exhibited distinctive size, density, and saucer-like morphology. Using PKH-26 and GFP-adenovirus infection, we demonstrated that exosomes are able to fuse and then release their protein content into dermal fibroblasts. Mass spectrometry and Western blotting identified five 14-3-3 isoforms (beta, gamma, epsilon, tau, and zeta) as MMP-1 stimulating factors for dermal fibroblasts. Immunoprecipation assays confirmed that these 14-3-3 isoforms account for almost the entire MMP-1 up-regulation induced by exosomes. In summary, our results demonstrated that circulating monocytes stimulated to be transformed into keratinocyte-like cells could promote an anti-fibrogenic commitment of dermal fibroblasts via exosomal 14-3-3 proteins." @default.
• W2040574003 created "2016-06-24" @default.
• W2040574003 creator A5011013562 @default.
• W2040574003 creator A5065038722 @default.
• W2040574003 date "2010-03-01" @default.
• W2040574003 modified "2023-09-26" @default.
• W2040574003 title "Transdifferentiated circulating monocytes release exosomes containing 14-3-3 proteins with matrix metalloproteinase-1 stimulating effect for dermal fibroblasts" @default.
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• W2040574003 doi "https://doi.org/10.1111/j.1524-475x.2010.00580.x" @default.
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