FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040576304> ?p ?o ?g. }

• W2040576304 endingPage "398" @default.
• W2040576304 startingPage "389" @default.
• W2040576304 abstract "Polyanions are potent HIV-1 entry inhibitors. Nevertheless, resistant viruses may emerge under polyanion inhibitory pressure. Specifically, a polyanion-resistant virus replicates in T cells even in the presence of high concentrations of polyanions. We found that although the polyanion-resistant virus grows in suspension CD4+ T cells efficiently, it infects nonlymphocytic adherent CD4+ cells poorly. Given that a main distinction between suspension and adherent cells is the absence or presence of cell-surface heparan sulfate proteoglycan (HSPG), we investigated if the failure of the polyanion-resistant virus to infect adherent CD4+ cells arises from its inability to bind HSPG. We found that the emergence of mutations in gp120 associated with polyanion resistance resulted in a decreased capacity of HIV-1 to bind HSPG. We also found that the polycation polybrene rescued the capacity of the polyanion-resistant virus to bind HSPG and to infect adherent CD4+ cells. The identification of this virus, unable to bind HSPG, provides a convenient probe to measure the impact of HIV-1-HSPG interactions in vivo. Altogether, these findings suggest that polyanion-resistance narrows the range of potential target cells for HIV-1 in the host. This reinforces the hypothesis that cell-free or cell-associated polyanions such as HSPG possess the capacity to modulate HIV-1 pathogenesis." @default.
• W2040576304 created "2016-06-24" @default.
• W2040576304 creator A5000769645 @default.
• W2040576304 creator A5021565808 @default.
• W2040576304 creator A5022208893 @default.
• W2040576304 creator A5060217430 @default.
• W2040576304 creator A5077558876 @default.
• W2040576304 creator A5082799543 @default.
• W2040576304 creator A5089522430 @default.
• W2040576304 date "2004-08-01" @default.
• W2040576304 modified "2023-10-13" @default.
• W2040576304 title "Effect of polyanion-resistance on HIV-1 infection" @default.
• W2040576304 cites W1884075248 @default.
• W2040576304 cites W1894273024 @default.
• W2040576304 cites W1927934418 @default.
• W2040576304 cites W1966393705 @default.
• W2040576304 cites W1969931362 @default.
• W2040576304 cites W1980383067 @default.
• W2040576304 cites W1981315157 @default.
• W2040576304 cites W1983454661 @default.
• W2040576304 cites W1985323085 @default.
• W2040576304 cites W1991686444 @default.
• W2040576304 cites W1994447004 @default.
• W2040576304 cites W2024734109 @default.
• W2040576304 cites W2043388188 @default.
• W2040576304 cites W2044821840 @default.
• W2040576304 cites W2046542318 @default.
• W2040576304 cites W2057461438 @default.
• W2040576304 cites W2059979504 @default.
• W2040576304 cites W2069094887 @default.
• W2040576304 cites W2081392883 @default.
• W2040576304 cites W2089609521 @default.
• W2040576304 cites W2092664889 @default.
• W2040576304 cites W2094228150 @default.
• W2040576304 cites W2100265029 @default.
• W2040576304 cites W2102237910 @default.
• W2040576304 cites W2115808507 @default.
• W2040576304 cites W2116566546 @default.
• W2040576304 cites W2121117011 @default.
• W2040576304 cites W2122496291 @default.
• W2040576304 cites W2128223406 @default.
• W2040576304 cites W2131692078 @default.
• W2040576304 cites W2132870230 @default.
• W2040576304 cites W2132905365 @default.
• W2040576304 cites W2135747811 @default.
• W2040576304 cites W2143360782 @default.
• W2040576304 cites W2144146891 @default.
• W2040576304 cites W2146478787 @default.
• W2040576304 cites W2158873843 @default.
• W2040576304 cites W2165866576 @default.
• W2040576304 cites W2169829977 @default.
• W2040576304 cites W2184573054 @default.
• W2040576304 cites W2331783667 @default.
• W2040576304 cites W2413846099 @default.
• W2040576304 doi "https://doi.org/10.1016/j.virol.2004.05.011" @default.
• W2040576304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15246277" @default.
• W2040576304 hasPublicationYear "2004" @default.
• W2040576304 type Work @default.
• W2040576304 sameAs 2040576304 @default.
• W2040576304 citedByCount "21" @default.
• W2040576304 countsByYear W20405763042014 @default.
• W2040576304 countsByYear W20405763042015 @default.
• W2040576304 countsByYear W20405763042016 @default.
• W2040576304 countsByYear W20405763042020 @default.
• W2040576304 countsByYear W20405763042021 @default.
• W2040576304 crossrefType "journal-article" @default.
• W2040576304 hasAuthorship W2040576304A5000769645 @default.
• W2040576304 hasAuthorship W2040576304A5021565808 @default.
• W2040576304 hasAuthorship W2040576304A5022208893 @default.
• W2040576304 hasAuthorship W2040576304A5060217430 @default.
• W2040576304 hasAuthorship W2040576304A5077558876 @default.
• W2040576304 hasAuthorship W2040576304A5082799543 @default.
• W2040576304 hasAuthorship W2040576304A5089522430 @default.
• W2040576304 hasConcept C12554922 @default.
• W2040576304 hasConcept C1491633281 @default.
• W2040576304 hasConcept C159047783 @default.
• W2040576304 hasConcept C189165786 @default.
• W2040576304 hasConcept C202751555 @default.
• W2040576304 hasConcept C2522874641 @default.
• W2040576304 hasConcept C2779335624 @default.
• W2040576304 hasConcept C54355233 @default.
• W2040576304 hasConcept C55493867 @default.
• W2040576304 hasConcept C81885089 @default.
• W2040576304 hasConcept C86803240 @default.
• W2040576304 hasConcept C95444343 @default.
• W2040576304 hasConceptScore W2040576304C12554922 @default.
• W2040576304 hasConceptScore W2040576304C1491633281 @default.
• W2040576304 hasConceptScore W2040576304C159047783 @default.
• W2040576304 hasConceptScore W2040576304C189165786 @default.
• W2040576304 hasConceptScore W2040576304C202751555 @default.
• W2040576304 hasConceptScore W2040576304C2522874641 @default.
• W2040576304 hasConceptScore W2040576304C2779335624 @default.
• W2040576304 hasConceptScore W2040576304C54355233 @default.
• W2040576304 hasConceptScore W2040576304C55493867 @default.
• W2040576304 hasConceptScore W2040576304C81885089 @default.
• W2040576304 hasConceptScore W2040576304C86803240 @default.
• W2040576304 hasConceptScore W2040576304C95444343 @default.
• W2040576304 hasIssue "2" @default.

• next