FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040576446> ?p ?o ?g. }

• W2040576446 endingPage "234" @default.
• W2040576446 startingPage "224" @default.
• W2040576446 abstract "The human subgroup C adenovirus (Ad) protein named adenovirus death protein (ADP) (previously named E3-11.6K) is synthesized at very late stages of infection when it mediates efficient lysis of cells and release of adenovirus to infect other cells. ADP is an integral membrane N-linked, O-linked palmitoylated glycoprotein of 101 amino acids (aa) that localizes to the nuclear membrane, endoplasmic reticulum (ER), and Golgi. It has a single membrane spanning region (roughly aa 40-60) and is oriented with aa 1-40 in the lumen and aa 61-101 in the nucleoplasm and cytoplasm. Using aa 61-101 of Ad2 ADP as bait in a yeast two-hybrid screen, we isolated a cDNA for a 211-aa protein that initially was not in the database but has now been published by others with the names human MAD2B, MAD2L2, and REV7. ADP binds strongly to human MAD2B not only in yeast but also in GST pull-down experiments and in coimmunoprecipitations of ADP and MAD2B synthesized in vitro or in vivo. ADP mutants with deletions throughout the bait region do not interact with human MAD2B, whereas a Pro69Pro70 to Ala69Ala70 mutant in the basic-proline domain of ADP does interact. Northern blot analyses indicate that human MAD2B is expressed ubiquitously. Human MAD2B is about 25% identical to human MAD2, a spindle assembly checkpoint protein. Two human A549 cell lines were made that constitutively overexpress MAD2B. Wild-type adenovirus lyses these cells significantly more slowly than it lyses parental A549 cells, raising the possibility that ADP and MAD2B act in opposition and suggesting that the ADP-MAD2B interaction is biologically relevant." @default.
• W2040576446 created "2016-06-24" @default.
• W2040576446 creator A5004508225 @default.
• W2040576446 creator A5032387026 @default.
• W2040576446 date "2003-08-01" @default.
• W2040576446 modified "2023-09-27" @default.
• W2040576446 title "Adenovirus ADP protein (E3-11.6K), which is required for efficient cell lysis and virus release, interacts with human MAD2B" @default.
• W2040576446 cites W1486479332 @default.
• W2040576446 cites W1903670736 @default.
• W2040576446 cites W1904318727 @default.
• W2040576446 cites W1946657588 @default.
• W2040576446 cites W1964849541 @default.
• W2040576446 cites W1968574939 @default.
• W2040576446 cites W1970916591 @default.
• W2040576446 cites W1991101546 @default.
• W2040576446 cites W2000639720 @default.
• W2040576446 cites W2001758369 @default.
• W2040576446 cites W2005603741 @default.
• W2040576446 cites W2007853809 @default.
• W2040576446 cites W2015851881 @default.
• W2040576446 cites W2016019304 @default.
• W2040576446 cites W2033141310 @default.
• W2040576446 cites W2036842448 @default.
• W2040576446 cites W2045713896 @default.
• W2040576446 cites W2049021232 @default.
• W2040576446 cites W2052127481 @default.
• W2040576446 cites W2063079466 @default.
• W2040576446 cites W2064967819 @default.
• W2040576446 cites W2066573335 @default.
• W2040576446 cites W2066780628 @default.
• W2040576446 cites W2071859150 @default.
• W2040576446 cites W2074881372 @default.
• W2040576446 cites W2075816732 @default.
• W2040576446 cites W2087094729 @default.
• W2040576446 cites W2097973787 @default.
• W2040576446 cites W2104775386 @default.
• W2040576446 cites W2106285650 @default.
• W2040576446 cites W2109425462 @default.
• W2040576446 cites W2112854488 @default.
• W2040576446 cites W2113127264 @default.
• W2040576446 cites W2118668591 @default.
• W2040576446 cites W2125982181 @default.
• W2040576446 cites W2142439440 @default.
• W2040576446 cites W2163010298 @default.
• W2040576446 cites W2163327939 @default.
• W2040576446 cites W2165703532 @default.
• W2040576446 cites W4241775513 @default.
• W2040576446 cites W4246976372 @default.
• W2040576446 doi "https://doi.org/10.1016/s0042-6822(03)00287-3" @default.
• W2040576446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12951035" @default.
• W2040576446 hasPublicationYear "2003" @default.
• W2040576446 type Work @default.
• W2040576446 sameAs 2040576446 @default.
• W2040576446 citedByCount "29" @default.
• W2040576446 countsByYear W20405764462012 @default.
• W2040576446 countsByYear W20405764462013 @default.
• W2040576446 countsByYear W20405764462017 @default.
• W2040576446 countsByYear W20405764462018 @default.
• W2040576446 countsByYear W20405764462019 @default.
• W2040576446 countsByYear W20405764462020 @default.
• W2040576446 countsByYear W20405764462021 @default.
• W2040576446 countsByYear W20405764462022 @default.
• W2040576446 crossrefType "journal-article" @default.
• W2040576446 hasAuthorship W2040576446A5004508225 @default.
• W2040576446 hasAuthorship W2040576446A5032387026 @default.
• W2040576446 hasConcept C105696609 @default.
• W2040576446 hasConcept C112952253 @default.
• W2040576446 hasConcept C1491633281 @default.
• W2040576446 hasConcept C153911025 @default.
• W2040576446 hasConcept C158617107 @default.
• W2040576446 hasConcept C183873130 @default.
• W2040576446 hasConcept C190062978 @default.
• W2040576446 hasConcept C2777563682 @default.
• W2040576446 hasConcept C2777896290 @default.
• W2040576446 hasConcept C29537977 @default.
• W2040576446 hasConcept C55493867 @default.
• W2040576446 hasConcept C86803240 @default.
• W2040576446 hasConcept C95444343 @default.
• W2040576446 hasConceptScore W2040576446C105696609 @default.
• W2040576446 hasConceptScore W2040576446C112952253 @default.
• W2040576446 hasConceptScore W2040576446C1491633281 @default.
• W2040576446 hasConceptScore W2040576446C153911025 @default.
• W2040576446 hasConceptScore W2040576446C158617107 @default.
• W2040576446 hasConceptScore W2040576446C183873130 @default.
• W2040576446 hasConceptScore W2040576446C190062978 @default.
• W2040576446 hasConceptScore W2040576446C2777563682 @default.
• W2040576446 hasConceptScore W2040576446C2777896290 @default.
• W2040576446 hasConceptScore W2040576446C29537977 @default.
• W2040576446 hasConceptScore W2040576446C55493867 @default.
• W2040576446 hasConceptScore W2040576446C86803240 @default.
• W2040576446 hasConceptScore W2040576446C95444343 @default.
• W2040576446 hasIssue "1" @default.
• W2040576446 hasLocation W20405764461 @default.
• W2040576446 hasLocation W20405764462 @default.
• W2040576446 hasOpenAccess W2040576446 @default.
• W2040576446 hasPrimaryLocation W20405764461 @default.
• W2040576446 hasRelatedWork W1967747113 @default.
• W2040576446 hasRelatedWork W2025492467 @default.

• next