FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040579405> ?p ?o ?g. }

• W2040579405 endingPage "e930" @default.
• W2040579405 startingPage "e930" @default.
• W2040579405 abstract "In almost all vertebrates, the downstream of the sox9 signaling axis is well conserved for testis differentiation. The upstream genes of this pathway vary from species to species during evolution. Yet, little is known about how these signaling cascades are regulated and what cellular processes are dominant in ovary–testis transformation in juvenile zebrafish. In this study, we find that the transforming gonads undergo activation of sox9a-expressing stromal cells with increased deposition of extracellular matrix and formation of degenerative compartments. This leads to follicle disassembly, oocyte degeneration, follicle cell-cyp19a1a-amh conversions, and, eventually, formation of the testis cord. In vitro primary culture of juvenile ovary tissue in gonadotropins increases cytoplasmic accumulation of sox9a and p-Erk1/2, and induces mesenchymal morphology. MAPK inhibitors (MKI), a mixture of PD98059 and U0216, eliminate the cytoplasmic distribution but do not eradicate nuclear localization of sox9a and p-Erk1/2. Nuclear p53 are relatively increased in MKI-treated cells that exhibit less spreading and reduced proliferation. Despite uniform nuclear condensation, only a fraction of cells displayed the apoptotic phenotype. These results suggest that high levels of cytoplasmic sox9a and p-Erk1/2 activity activate stromal cells and enhance the production of extracellular matrix required for testis cord formation, whereas deregulation and translocation of sox9a and p-Erk1/2 induce follicle disassembly and incomplete apoptosis associated with nuclear p53. Together with the established FSH/cAMP/MAPK/AMH pathway in mammalian granulosa and Sertoli cells, we demonstrated that the sox9 axis signaling that determines testis formation in mammals also induces zebrafish ovary–testis transition, and adds to its conserved role in sex reversal." @default.
• W2040579405 created "2016-06-24" @default.
• W2040579405 creator A5009557503 @default.
• W2040579405 creator A5013184700 @default.
• W2040579405 creator A5025870773 @default.
• W2040579405 creator A5030473640 @default.
• W2040579405 creator A5031807603 @default.
• W2040579405 creator A5055412481 @default.
• W2040579405 date "2013-11-21" @default.
• W2040579405 modified "2023-10-16" @default.
• W2040579405 title "Sox9-related signaling controls zebrafish juvenile ovary–testis transformation" @default.
• W2040579405 cites W179665357 @default.
• W2040579405 cites W1980520263 @default.
• W2040579405 cites W1997410018 @default.
• W2040579405 cites W2006644160 @default.
• W2040579405 cites W2008606131 @default.
• W2040579405 cites W2011606314 @default.
• W2040579405 cites W2015489559 @default.
• W2040579405 cites W2020670520 @default.
• W2040579405 cites W2022651712 @default.
• W2040579405 cites W2029552542 @default.
• W2040579405 cites W2030851423 @default.
• W2040579405 cites W2043529571 @default.
• W2040579405 cites W2049698925 @default.
• W2040579405 cites W2050371513 @default.
• W2040579405 cites W2062003019 @default.
• W2040579405 cites W2094739415 @default.
• W2040579405 cites W2102277884 @default.
• W2040579405 cites W2109971484 @default.
• W2040579405 cites W2113714901 @default.
• W2040579405 cites W2117919012 @default.
• W2040579405 cites W2119491918 @default.
• W2040579405 cites W2120636655 @default.
• W2040579405 cites W2137168087 @default.
• W2040579405 cites W2137232121 @default.
• W2040579405 cites W2162581076 @default.
• W2040579405 cites W2163735827 @default.
• W2040579405 cites W2266093504 @default.
• W2040579405 doi "https://doi.org/10.1038/cddis.2013.456" @default.
• W2040579405 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3847332" @default.
• W2040579405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24263104" @default.
• W2040579405 hasPublicationYear "2013" @default.
• W2040579405 type Work @default.
• W2040579405 sameAs 2040579405 @default.
• W2040579405 citedByCount "55" @default.
• W2040579405 countsByYear W20405794052014 @default.
• W2040579405 countsByYear W20405794052015 @default.
• W2040579405 countsByYear W20405794052016 @default.
• W2040579405 countsByYear W20405794052017 @default.
• W2040579405 countsByYear W20405794052018 @default.
• W2040579405 countsByYear W20405794052019 @default.
• W2040579405 countsByYear W20405794052020 @default.
• W2040579405 countsByYear W20405794052021 @default.
• W2040579405 countsByYear W20405794052022 @default.
• W2040579405 countsByYear W20405794052023 @default.
• W2040579405 crossrefType "journal-article" @default.
• W2040579405 hasAuthorship W2040579405A5009557503 @default.
• W2040579405 hasAuthorship W2040579405A5013184700 @default.
• W2040579405 hasAuthorship W2040579405A5025870773 @default.
• W2040579405 hasAuthorship W2040579405A5030473640 @default.
• W2040579405 hasAuthorship W2040579405A5031807603 @default.
• W2040579405 hasAuthorship W2040579405A5055412481 @default.
• W2040579405 hasBestOaLocation W20405794051 @default.
• W2040579405 hasConcept C104317684 @default.
• W2040579405 hasConcept C123765429 @default.
• W2040579405 hasConcept C126322002 @default.
• W2040579405 hasConcept C134018914 @default.
• W2040579405 hasConcept C16930146 @default.
• W2040579405 hasConcept C2776878037 @default.
• W2040579405 hasConcept C2778486617 @default.
• W2040579405 hasConcept C2781068068 @default.
• W2040579405 hasConcept C502942594 @default.
• W2040579405 hasConcept C54355233 @default.
• W2040579405 hasConcept C71924100 @default.
• W2040579405 hasConcept C86339819 @default.
• W2040579405 hasConcept C86803240 @default.
• W2040579405 hasConcept C95444343 @default.
• W2040579405 hasConceptScore W2040579405C104317684 @default.
• W2040579405 hasConceptScore W2040579405C123765429 @default.
• W2040579405 hasConceptScore W2040579405C126322002 @default.
• W2040579405 hasConceptScore W2040579405C134018914 @default.
• W2040579405 hasConceptScore W2040579405C16930146 @default.
• W2040579405 hasConceptScore W2040579405C2776878037 @default.
• W2040579405 hasConceptScore W2040579405C2778486617 @default.
• W2040579405 hasConceptScore W2040579405C2781068068 @default.
• W2040579405 hasConceptScore W2040579405C502942594 @default.
• W2040579405 hasConceptScore W2040579405C54355233 @default.
• W2040579405 hasConceptScore W2040579405C71924100 @default.
• W2040579405 hasConceptScore W2040579405C86339819 @default.
• W2040579405 hasConceptScore W2040579405C86803240 @default.
• W2040579405 hasConceptScore W2040579405C95444343 @default.
• W2040579405 hasIssue "11" @default.
• W2040579405 hasLocation W20405794051 @default.
• W2040579405 hasLocation W20405794052 @default.
• W2040579405 hasLocation W20405794053 @default.
• W2040579405 hasLocation W20405794054 @default.
• W2040579405 hasOpenAccess W2040579405 @default.
• W2040579405 hasPrimaryLocation W20405794051 @default.

• next