FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040579630> ?p ?o ?g. }

• W2040579630 endingPage "645" @default.
• W2040579630 startingPage "637" @default.
• W2040579630 abstract "On attempts to identify toxins showing original profile of activity among K+ channels, we purified Kbot1, a scorpion toxin that blocks Kv1 and SK potassium channels. With 28 amino-acid residues, Kbot1 is the shortest toxin sequenced in Buthus occitanus scorpion. It is linked by three disulfide bridges and its primary structure is 93% identical to that of BmP02 isolated from the venom of the Chinese scorpion Buthus martensi Karsch [Eur. J. Biochem. 245 (1996) 457]. Kbot1 exhibited a low neurotoxicity in mice after intracerebroventricular injection (LD50 approximately or = 0.8 microg per mouse). It competes with iodinated apamin for its rat brain synaptosomal membrane-binding site (IC50 of 20 nM). Despite 30% sequence identity between Kbot1 and ChTX, competitive experiments on the [125I] charybdotoxin, show that Kbot1 inhibits its binding to its rat brain synaptosomes with IC50 of 10 nM. This result was supported by electrophysiological experiments on cloned voltage-dependent K+ channels from rat brain, expressed in Xenopus oocytes. Kbot1 blocks Kv1.1, Kv1.2 and Kv1.3 currents with IC50 of 145, 2.5 and 15 nM, respectively. Based on these data, Kbot1 may be considered as the first member of subfamily 9 of scorpion toxins [Trends Pharmacol. Sci. 20 (1999) 444], highly active on both Kv and SK channels." @default.
• W2040579630 created "2016-06-24" @default.
• W2040579630 creator A5008575369 @default.
• W2040579630 creator A5027997594 @default.
• W2040579630 creator A5051611497 @default.
• W2040579630 creator A5053485166 @default.
• W2040579630 creator A5085581325 @default.
• W2040579630 date "2004-04-01" @default.
• W2040579630 modified "2023-10-14" @default.
• W2040579630 title "Kbot1, a three disulfide bridges toxin from Buthus occitanus tunetanus venom highly active on both SK and Kv channels" @default.
• W2040579630 cites W1518984762 @default.
• W2040579630 cites W1523536119 @default.
• W2040579630 cites W1525085839 @default.
• W2040579630 cites W1528983773 @default.
• W2040579630 cites W1579386572 @default.
• W2040579630 cites W1602607306 @default.
• W2040579630 cites W1603793449 @default.
• W2040579630 cites W1830737945 @default.
• W2040579630 cites W1869944834 @default.
• W2040579630 cites W1968441592 @default.
• W2040579630 cites W1969239953 @default.
• W2040579630 cites W1974447707 @default.
• W2040579630 cites W1975085160 @default.
• W2040579630 cites W1980330700 @default.
• W2040579630 cites W1985095190 @default.
• W2040579630 cites W1985528176 @default.
• W2040579630 cites W1989736892 @default.
• W2040579630 cites W1993802295 @default.
• W2040579630 cites W1997867282 @default.
• W2040579630 cites W2007452911 @default.
• W2040579630 cites W2013137776 @default.
• W2040579630 cites W2013802987 @default.
• W2040579630 cites W2015642465 @default.
• W2040579630 cites W2024341961 @default.
• W2040579630 cites W2035729421 @default.
• W2040579630 cites W2036209063 @default.
• W2040579630 cites W2039690897 @default.
• W2040579630 cites W2045695538 @default.
• W2040579630 cites W2048754200 @default.
• W2040579630 cites W2049100140 @default.
• W2040579630 cites W2050216084 @default.
• W2040579630 cites W2056041099 @default.
• W2040579630 cites W2056220096 @default.
• W2040579630 cites W2069501898 @default.
• W2040579630 cites W2071546597 @default.
• W2040579630 cites W2071752662 @default.
• W2040579630 cites W2073858652 @default.
• W2040579630 cites W2078894239 @default.
• W2040579630 cites W2091499426 @default.
• W2040579630 cites W2104024569 @default.
• W2040579630 cites W2114443373 @default.
• W2040579630 cites W2129253766 @default.
• W2040579630 cites W2141557739 @default.
• W2040579630 cites W2142215909 @default.
• W2040579630 cites W2168525050 @default.
• W2040579630 cites W2225255522 @default.
• W2040579630 cites W2280944446 @default.
• W2040579630 cites W2504414049 @default.
• W2040579630 doi "https://doi.org/10.1016/j.peptides.2004.02.017" @default.
• W2040579630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15165720" @default.
• W2040579630 hasPublicationYear "2004" @default.
• W2040579630 type Work @default.
• W2040579630 sameAs 2040579630 @default.
• W2040579630 citedByCount "21" @default.
• W2040579630 countsByYear W20405796302012 @default.
• W2040579630 countsByYear W20405796302014 @default.
• W2040579630 countsByYear W20405796302015 @default.
• W2040579630 countsByYear W20405796302016 @default.
• W2040579630 countsByYear W20405796302017 @default.
• W2040579630 countsByYear W20405796302018 @default.
• W2040579630 countsByYear W20405796302019 @default.
• W2040579630 countsByYear W20405796302022 @default.
• W2040579630 countsByYear W20405796302023 @default.
• W2040579630 crossrefType "journal-article" @default.
• W2040579630 hasAuthorship W2040579630A5008575369 @default.
• W2040579630 hasAuthorship W2040579630A5027997594 @default.
• W2040579630 hasAuthorship W2040579630A5051611497 @default.
• W2040579630 hasAuthorship W2040579630A5053485166 @default.
• W2040579630 hasAuthorship W2040579630A5085581325 @default.
• W2040579630 hasConcept C12554922 @default.
• W2040579630 hasConcept C178790620 @default.
• W2040579630 hasConcept C185592680 @default.
• W2040579630 hasConcept C2776676993 @default.
• W2040579630 hasConcept C2776919887 @default.
• W2040579630 hasConcept C2777367657 @default.
• W2040579630 hasConcept C2777884321 @default.
• W2040579630 hasConcept C2778457506 @default.
• W2040579630 hasConcept C2779448229 @default.
• W2040579630 hasConcept C2779491297 @default.
• W2040579630 hasConcept C2780419564 @default.
• W2040579630 hasConcept C2910159647 @default.
• W2040579630 hasConcept C29730261 @default.
• W2040579630 hasConcept C55493867 @default.
• W2040579630 hasConcept C83743174 @default.
• W2040579630 hasConcept C86803240 @default.
• W2040579630 hasConceptScore W2040579630C12554922 @default.
• W2040579630 hasConceptScore W2040579630C178790620 @default.
• W2040579630 hasConceptScore W2040579630C185592680 @default.

• next