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- W2040584849 abstract "Sulfide and sulfonyl derivatives of 1,2,4-oxadiazoles were synthesized and screened by MTT assay on the prostate cancer cells, DU-145. Six compounds were identified as potential anti-prostate cancer agents with IC50 values ranging from 0.5 to 5.1 μM. These compounds exhibited good activity on the androgen independent cells PC-3, while the results were moderate on androgen dependent LNCaP cells, suggesting the possibility of a mechanism of action different from that of the bioisosteric bicalutamide. Also a very low cytotoxicity was observed on non-cancerous cells MCF-10A." @default.
- W2040584849 created "2016-06-24" @default.
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- W2040584849 date "2012-03-01" @default.
- W2040584849 modified "2023-09-26" @default.
- W2040584849 title "1,2,4-Oxadiazoles: A new class of anti-prostate cancer agents" @default.
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- W2040584849 doi "https://doi.org/10.1016/j.bmcl.2012.01.059" @default.
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