FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040586395> ?p ?o ?g. }

• W2040586395 endingPage "37070" @default.
• W2040586395 startingPage "37057" @default.
• W2040586395 abstract "p24 family proteins are evolutionarily conserved transmembrane proteins involved in the early secretory pathway. Saccharomyces cerevisiae has 8 known p24 proteins that are classified into four subfamilies (p24α, -β, -γ, and -δ). Emp24 and Erv25 are the sole members of p24β and -δ, respectively, and deletion of either destabilizes the remaining p24 proteins, resulting in p24 null phenotype (p24Δ). We studied genetic and physical interactions of p24α (Erp1, -5, and -6) and γ (Erp2, -3, and -4). Deletion of the major p24α (Erp1) partially inhibited p24 activity as reported previously. A second mutation in either Erp5 or Erp6 aggravated the erp1Δ phenotype, and the triple mutation gave a full p24Δ phenotype. Similar genetic interactions were observed among the major p24γ (Erp2) and the other two γ members. All the p24α/γ isoforms interacted with both p24β and -δ. Interaction between p24β and -δ was isoform-selective, and five major α/γ pairs were detected. These results suggest that the yeast p24 proteins form functionally redundant αβγδ complexes. We also identified Rrt6 as a novel p24δ isoform. Rrt6 shows only limited sequence identity (∼15%) to known p24 proteins but was found to have structural properties characteristic of p24. Rrt6 was induced when cells were grown on glycerol and form an additional αβγδ complex with Erp3, Erp5, and Emp24. This complex was mainly localized to the Golgi, whereas the p24 complex containing Erv25, instead of Rrt6 but otherwise with the same isoform composition, was found mostly in the ER. p24 family proteins are evolutionarily conserved transmembrane proteins involved in the early secretory pathway. Saccharomyces cerevisiae has 8 known p24 proteins that are classified into four subfamilies (p24α, -β, -γ, and -δ). Emp24 and Erv25 are the sole members of p24β and -δ, respectively, and deletion of either destabilizes the remaining p24 proteins, resulting in p24 null phenotype (p24Δ). We studied genetic and physical interactions of p24α (Erp1, -5, and -6) and γ (Erp2, -3, and -4). Deletion of the major p24α (Erp1) partially inhibited p24 activity as reported previously. A second mutation in either Erp5 or Erp6 aggravated the erp1Δ phenotype, and the triple mutation gave a full p24Δ phenotype. Similar genetic interactions were observed among the major p24γ (Erp2) and the other two γ members. All the p24α/γ isoforms interacted with both p24β and -δ. Interaction between p24β and -δ was isoform-selective, and five major α/γ pairs were detected. These results suggest that the yeast p24 proteins form functionally redundant αβγδ complexes. We also identified Rrt6 as a novel p24δ isoform. Rrt6 shows only limited sequence identity (∼15%) to known p24 proteins but was found to have structural properties characteristic of p24. Rrt6 was induced when cells were grown on glycerol and form an additional αβγδ complex with Erp3, Erp5, and Emp24. This complex was mainly localized to the Golgi, whereas the p24 complex containing Erv25, instead of Rrt6 but otherwise with the same isoform composition, was found mostly in the ER." @default.
• W2040586395 created "2016-06-24" @default.
• W2040586395 creator A5047764349 @default.
• W2040586395 creator A5065979182 @default.
• W2040586395 creator A5069249615 @default.
• W2040586395 date "2013-12-01" @default.
• W2040586395 modified "2023-10-17" @default.
• W2040586395 title "Isoform-selective Oligomer Formation of Saccharomyces cerevisiae p24 Family Proteins" @default.
• W2040586395 cites W1547269929 @default.
• W2040586395 cites W1584629841 @default.
• W2040586395 cites W1972341173 @default.
• W2040586395 cites W1974654475 @default.
• W2040586395 cites W1979845325 @default.
• W2040586395 cites W1981755684 @default.
• W2040586395 cites W1981765089 @default.
• W2040586395 cites W1984311414 @default.
• W2040586395 cites W1984347348 @default.
• W2040586395 cites W1987021757 @default.
• W2040586395 cites W1987553882 @default.
• W2040586395 cites W1996930443 @default.
• W2040586395 cites W2004574087 @default.
• W2040586395 cites W2005576231 @default.
• W2040586395 cites W2005798875 @default.
• W2040586395 cites W2009855315 @default.
• W2040586395 cites W2014251406 @default.
• W2040586395 cites W2014934562 @default.
• W2040586395 cites W2020044636 @default.
• W2040586395 cites W2021125519 @default.
• W2040586395 cites W2022404904 @default.
• W2040586395 cites W2025593660 @default.
• W2040586395 cites W2029167074 @default.
• W2040586395 cites W2031854250 @default.
• W2040586395 cites W2037185463 @default.
• W2040586395 cites W2046332353 @default.
• W2040586395 cites W2049813270 @default.
• W2040586395 cites W2053890782 @default.
• W2040586395 cites W2065897005 @default.
• W2040586395 cites W2066054990 @default.
• W2040586395 cites W2066118167 @default.
• W2040586395 cites W2070136749 @default.
• W2040586395 cites W2072135664 @default.
• W2040586395 cites W2073195862 @default.
• W2040586395 cites W2077237389 @default.
• W2040586395 cites W2081933515 @default.
• W2040586395 cites W2092179351 @default.
• W2040586395 cites W2092469992 @default.
• W2040586395 cites W2094201044 @default.
• W2040586395 cites W2095429868 @default.
• W2040586395 cites W2098135462 @default.
• W2040586395 cites W2099654977 @default.
• W2040586395 cites W2100208451 @default.
• W2040586395 cites W2105642340 @default.
• W2040586395 cites W2105683715 @default.
• W2040586395 cites W2106792596 @default.
• W2040586395 cites W2109664412 @default.
• W2040586395 cites W2109975639 @default.
• W2040586395 cites W2114827973 @default.
• W2040586395 cites W2119647283 @default.
• W2040586395 cites W2120987137 @default.
• W2040586395 cites W2124865779 @default.
• W2040586395 cites W2127540366 @default.
• W2040586395 cites W2128201616 @default.
• W2040586395 cites W2129987474 @default.
• W2040586395 cites W2130439682 @default.
• W2040586395 cites W2131807617 @default.
• W2040586395 cites W2140936469 @default.
• W2040586395 cites W2146309455 @default.
• W2040586395 cites W2146401960 @default.
• W2040586395 cites W2146503498 @default.
• W2040586395 cites W2147319025 @default.
• W2040586395 cites W2148490163 @default.
• W2040586395 cites W2152392529 @default.
• W2040586395 cites W2152934236 @default.
• W2040586395 cites W2153187042 @default.
• W2040586395 cites W2154046032 @default.
• W2040586395 cites W2155694346 @default.
• W2040586395 cites W2158535876 @default.
• W2040586395 cites W2161801553 @default.
• W2040586395 cites W2167837958 @default.
• W2040586395 cites W2169333620 @default.
• W2040586395 cites W2170752133 @default.
• W2040586395 cites W2171569102 @default.
• W2040586395 cites W2293756113 @default.
• W2040586395 cites W4320301318 @default.
• W2040586395 cites W999658805 @default.
• W2040586395 doi "https://doi.org/10.1074/jbc.m113.518340" @default.
• W2040586395 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3873562" @default.
• W2040586395 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24217251" @default.
• W2040586395 hasPublicationYear "2013" @default.
• W2040586395 type Work @default.
• W2040586395 sameAs 2040586395 @default.
• W2040586395 citedByCount "16" @default.
• W2040586395 countsByYear W20405863952014 @default.
• W2040586395 countsByYear W20405863952015 @default.
• W2040586395 countsByYear W20405863952016 @default.
• W2040586395 countsByYear W20405863952017 @default.
• W2040586395 countsByYear W20405863952019 @default.
• W2040586395 countsByYear W20405863952020 @default.

• next