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- W2040587260 abstract "<h2>Abstract</h2> Gases are extremely soluble in fluorocarbon fluids and therefore they can serve as respirator media in intact animals. In the form of fine emulsions they can substitute for the gas-exchange function of red cells in isolated, perfused organs. Rabbits were anaesthetized with Nembutal and respired with room air. In six of them the blood was exchanged slowly for an iso-osmotic, buffered plasma-expander, and in nine other rabbits it was exchanged for 10% or 20% fluorocarbon emulsified into the plasma-expander. The diameters of about 90% of the fluorocarbon microspheres were in the range 1·5–5 μm. In both groups the haematocrit was lowered to less than 5%. Throughout the procedure, measurements were made of arterial and venous PO<sub>2</sub> PCO<sub>2</sub>, pH, oxygen content, oxygen extraction, standard bicarbonate, left ventricular pressure, central venous pressure, heart rate and temperature. None of these parameters, nor the survival time of about 30 min, showed a statistically significant difference between the two groups of severely anaemic animals. The cause of death was myocardial depression. It was concluded that the inefficiency of fluorocarbon emulsions to deliver oxygen to the tissues of intact animals was probably due to the presence of protein molecules in concentrations as low as a few micrograms per 100 ml, which could change the tension of the water-fluorocarbon interface. In perfused small organs or organisms the protein content is probably too low to block oxygen diffusion from the fluorocarbon particles." @default.
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- W2040587260 date "1972-09-01" @default.
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- W2040587260 title "Experimental study of perfusion of rabbits with fluorocarbon fluid in the acute asanguineous state" @default.
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- W2040587260 doi "https://doi.org/10.1016/0300-9572(72)90053-6" @default.
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