Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040590506> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2040590506 endingPage "550" @default.
- W2040590506 startingPage "544" @default.
- W2040590506 abstract "Thiocolchicine, a colchicine analog in which the C-10 methoxy is replaced with a thiomethyl moiety, was shown to bind with high affinity to the colchicine site on tubulin (Ka = 1.07 +/- 0.14 x 10(6) M-1 at 23 degrees C). Like colchicine, the association kinetics were biphasic, and the rate constants of both phases were temperature dependent. The rate constant of the fast phase of the association was 4 times greater than the rate constant for colchicine binding, and the activation energy was lower (19.1 +/- 1.8 kcal/mol). X-ray crystallographic analysis shows that thiocolchicine displays greater puckering of the tropone C ring than colchicine (Koerntgen, C. and Margulis, T. N. (1977) J. Pharm. Sci. 66, 1127-1131.). These results indicate that the conformation of the C ring may have little effect on the energetics of colchicinoids binding to tubulin." @default.
- W2040590506 created "2016-06-24" @default.
- W2040590506 creator A5026107606 @default.
- W2040590506 creator A5086160078 @default.
- W2040590506 date "1989-06-01" @default.
- W2040590506 modified "2023-09-24" @default.
- W2040590506 title "Association of thiocolchicine with tubulin" @default.
- W2040590506 cites W1121095085 @default.
- W2040590506 cites W1507453253 @default.
- W2040590506 cites W1510434718 @default.
- W2040590506 cites W1544443580 @default.
- W2040590506 cites W1571706159 @default.
- W2040590506 cites W1578505552 @default.
- W2040590506 cites W1966439058 @default.
- W2040590506 cites W1973573929 @default.
- W2040590506 cites W1973979248 @default.
- W2040590506 cites W2010567389 @default.
- W2040590506 cites W2018439225 @default.
- W2040590506 cites W2046108731 @default.
- W2040590506 cites W2047733244 @default.
- W2040590506 cites W2056685616 @default.
- W2040590506 cites W2077232837 @default.
- W2040590506 cites W2134518189 @default.
- W2040590506 cites W2141128434 @default.
- W2040590506 doi "https://doi.org/10.1016/0006-291x(89)92633-8" @default.
- W2040590506 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2735908" @default.
- W2040590506 hasPublicationYear "1989" @default.
- W2040590506 type Work @default.
- W2040590506 sameAs 2040590506 @default.
- W2040590506 citedByCount "17" @default.
- W2040590506 countsByYear W20405905062012 @default.
- W2040590506 countsByYear W20405905062013 @default.
- W2040590506 countsByYear W20405905062015 @default.
- W2040590506 countsByYear W20405905062016 @default.
- W2040590506 countsByYear W20405905062018 @default.
- W2040590506 crossrefType "journal-article" @default.
- W2040590506 hasAuthorship W2040590506A5026107606 @default.
- W2040590506 hasAuthorship W2040590506A5086160078 @default.
- W2040590506 hasConcept C121332964 @default.
- W2040590506 hasConcept C148898269 @default.
- W2040590506 hasConcept C178790620 @default.
- W2040590506 hasConcept C185592680 @default.
- W2040590506 hasConcept C20418707 @default.
- W2040590506 hasConcept C2776219776 @default.
- W2040590506 hasConcept C2776568683 @default.
- W2040590506 hasConcept C2776636253 @default.
- W2040590506 hasConcept C2780378348 @default.
- W2040590506 hasConcept C54355233 @default.
- W2040590506 hasConcept C62520636 @default.
- W2040590506 hasConcept C71240020 @default.
- W2040590506 hasConcept C8010536 @default.
- W2040590506 hasConcept C84425145 @default.
- W2040590506 hasConcept C86803240 @default.
- W2040590506 hasConcept C93391505 @default.
- W2040590506 hasConcept C95444343 @default.
- W2040590506 hasConceptScore W2040590506C121332964 @default.
- W2040590506 hasConceptScore W2040590506C148898269 @default.
- W2040590506 hasConceptScore W2040590506C178790620 @default.
- W2040590506 hasConceptScore W2040590506C185592680 @default.
- W2040590506 hasConceptScore W2040590506C20418707 @default.
- W2040590506 hasConceptScore W2040590506C2776219776 @default.
- W2040590506 hasConceptScore W2040590506C2776568683 @default.
- W2040590506 hasConceptScore W2040590506C2776636253 @default.
- W2040590506 hasConceptScore W2040590506C2780378348 @default.
- W2040590506 hasConceptScore W2040590506C54355233 @default.
- W2040590506 hasConceptScore W2040590506C62520636 @default.
- W2040590506 hasConceptScore W2040590506C71240020 @default.
- W2040590506 hasConceptScore W2040590506C8010536 @default.
- W2040590506 hasConceptScore W2040590506C84425145 @default.
- W2040590506 hasConceptScore W2040590506C86803240 @default.
- W2040590506 hasConceptScore W2040590506C93391505 @default.
- W2040590506 hasConceptScore W2040590506C95444343 @default.
- W2040590506 hasIssue "2" @default.
- W2040590506 hasLocation W20405905061 @default.
- W2040590506 hasLocation W20405905062 @default.
- W2040590506 hasOpenAccess W2040590506 @default.
- W2040590506 hasPrimaryLocation W20405905061 @default.
- W2040590506 hasRelatedWork W1984118702 @default.
- W2040590506 hasRelatedWork W1994113796 @default.
- W2040590506 hasRelatedWork W2009941152 @default.
- W2040590506 hasRelatedWork W2021127564 @default.
- W2040590506 hasRelatedWork W2034914503 @default.
- W2040590506 hasRelatedWork W2040590506 @default.
- W2040590506 hasRelatedWork W2053466724 @default.
- W2040590506 hasRelatedWork W2053545605 @default.
- W2040590506 hasRelatedWork W2428632997 @default.
- W2040590506 hasRelatedWork W2949563606 @default.
- W2040590506 hasVolume "161" @default.
- W2040590506 isParatext "false" @default.
- W2040590506 isRetracted "false" @default.
- W2040590506 magId "2040590506" @default.
- W2040590506 workType "article" @default.