Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040591877> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2040591877 abstract "The promoter of the ornithine decarboxylase (ODC) gene contains two E-boxes, which are critical sites for transcriptional activation by the binding of c-Myc-Max heterodimers. We have identified heterogeneous nuclear ribonuclear protein U (hnRNP U) as a component of the complex formed on the E-box-containing promoter region of the ODC gene by using DNA-affinity chromatography, immunoprecipitation and chromatin immunoprecipitation assays. The N-terminal domain of hnRNP U was responsible for the association with c-Myc-Max complex. Down-regulation of hnRNP U with RNA interference blocked the induction of the ODC gene and cell growth by serum stimulation, suggesting that hnRNP U is a coactivator of the c-Myc-Max complex and essential for cell proliferation. Electrophoretic mobility-shift assays revealed that the segment between the two E-boxes in the promoter is the primary binding site of hnRNP U. The putative binding sequence was narrowed-down to a 13-nucleotide segment by comparing the sequence between the E-boxes with the binding sites of hnRNP U, which were recently identified in the promoter of Bmal1, a core component of the circadian molecular oscillator. These findings increase our knowledge of how the c-Myc-Max complex exerts its transcriptional regulatory role and suggest that hnRNP U may be a coactivator of this transcriptional activator complex." @default.
- W2040591877 created "2016-06-24" @default.
- W2040591877 creator A5017447129 @default.
- W2040591877 date "2009-07-06" @default.
- W2040591877 modified "2023-09-28" @default.
- W2040591877 title "hnRNP U interacts with the c-Myc-Max complex on the E-box promoter region inducing the ornithine decarboxylase gene" @default.
- W2040591877 doi "https://doi.org/10.3892/or_00000431" @default.
- W2040591877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19578763" @default.
- W2040591877 hasPublicationYear "2009" @default.
- W2040591877 type Work @default.
- W2040591877 sameAs 2040591877 @default.
- W2040591877 citedByCount "3" @default.
- W2040591877 countsByYear W20405918772013 @default.
- W2040591877 countsByYear W20405918772017 @default.
- W2040591877 crossrefType "journal-article" @default.
- W2040591877 hasAuthorship W2040591877A5017447129 @default.
- W2040591877 hasBestOaLocation W20405918771 @default.
- W2040591877 hasConcept C101762097 @default.
- W2040591877 hasConcept C104317684 @default.
- W2040591877 hasConcept C108905728 @default.
- W2040591877 hasConcept C121289238 @default.
- W2040591877 hasConcept C134320426 @default.
- W2040591877 hasConcept C138885662 @default.
- W2040591877 hasConcept C150194340 @default.
- W2040591877 hasConcept C153911025 @default.
- W2040591877 hasConcept C179926584 @default.
- W2040591877 hasConcept C181199279 @default.
- W2040591877 hasConcept C183873130 @default.
- W2040591877 hasConcept C183978625 @default.
- W2040591877 hasConcept C190062978 @default.
- W2040591877 hasConcept C2776525860 @default.
- W2040591877 hasConcept C41895202 @default.
- W2040591877 hasConcept C54355233 @default.
- W2040591877 hasConcept C55493867 @default.
- W2040591877 hasConcept C71829478 @default.
- W2040591877 hasConcept C77445288 @default.
- W2040591877 hasConcept C86339819 @default.
- W2040591877 hasConcept C86803240 @default.
- W2040591877 hasConcept C95444343 @default.
- W2040591877 hasConceptScore W2040591877C101762097 @default.
- W2040591877 hasConceptScore W2040591877C104317684 @default.
- W2040591877 hasConceptScore W2040591877C108905728 @default.
- W2040591877 hasConceptScore W2040591877C121289238 @default.
- W2040591877 hasConceptScore W2040591877C134320426 @default.
- W2040591877 hasConceptScore W2040591877C138885662 @default.
- W2040591877 hasConceptScore W2040591877C150194340 @default.
- W2040591877 hasConceptScore W2040591877C153911025 @default.
- W2040591877 hasConceptScore W2040591877C179926584 @default.
- W2040591877 hasConceptScore W2040591877C181199279 @default.
- W2040591877 hasConceptScore W2040591877C183873130 @default.
- W2040591877 hasConceptScore W2040591877C183978625 @default.
- W2040591877 hasConceptScore W2040591877C190062978 @default.
- W2040591877 hasConceptScore W2040591877C2776525860 @default.
- W2040591877 hasConceptScore W2040591877C41895202 @default.
- W2040591877 hasConceptScore W2040591877C54355233 @default.
- W2040591877 hasConceptScore W2040591877C55493867 @default.
- W2040591877 hasConceptScore W2040591877C71829478 @default.
- W2040591877 hasConceptScore W2040591877C77445288 @default.
- W2040591877 hasConceptScore W2040591877C86339819 @default.
- W2040591877 hasConceptScore W2040591877C86803240 @default.
- W2040591877 hasConceptScore W2040591877C95444343 @default.
- W2040591877 hasLocation W20405918771 @default.
- W2040591877 hasLocation W20405918772 @default.
- W2040591877 hasOpenAccess W2040591877 @default.
- W2040591877 hasPrimaryLocation W20405918771 @default.
- W2040591877 hasRelatedWork W2009966535 @default.
- W2040591877 hasRelatedWork W2040591877 @default.
- W2040591877 hasRelatedWork W2139896766 @default.
- W2040591877 hasRelatedWork W2393628859 @default.
- W2040591877 hasRelatedWork W2413146854 @default.
- W2040591877 hasRelatedWork W2471443024 @default.
- W2040591877 hasRelatedWork W2886854581 @default.
- W2040591877 hasRelatedWork W2917137742 @default.
- W2040591877 hasRelatedWork W2969657660 @default.
- W2040591877 hasRelatedWork W3028664918 @default.
- W2040591877 isParatext "false" @default.
- W2040591877 isRetracted "false" @default.
- W2040591877 magId "2040591877" @default.
- W2040591877 workType "article" @default.