Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040593990> ?p ?o ?g. }
- W2040593990 endingPage "4096" @default.
- W2040593990 startingPage "4090" @default.
- W2040593990 abstract "Reaction of the dimer [(η5-C5Me5)RhCl(μ2-Cl)]2 with 2 or 4 equiv of the water-soluble phosphine 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane (pta) affords [Rh(η5-C5Me5)(pta)Cl2] and [Rh(η5-C5Me5)(pta)2Cl]Cl, respectively. Both complexes have been characterized in solution by NMR spectroscopy and in the solid state by single-crystal X-ray diffraction, the latter as the chloride and BPh4- salts. In addition, the rhodium(I) complexes [Rh(η5-C5Me5)(CO)(pta)] and [Rh(η5-C5H5)(pta)2] have been prepared from [Rh(η5-C5Me5)(CO)2] and [Rh(η5-C5H5)(PPh3)2], respectively, by reaction with pta. An in vitro evaluation of these compounds, together with [Os(η6-C10H14)(pta)Cl2] and the well-characterized antimetastasis drug [Ru(η6-C10H14)(pta)Cl2], RAPTA-C, was undertaken using HT29 colon carcinoma, A549 lung carcinoma, and T47D breast carcinoma cells. In the HT29 cell line, the two nearest congeners to [Ru(η6-C10H14)(pta)Cl2], viz., [Rh(η5-C5Me5)(pta)Cl2] and [Os(η6-C10H14)(pta)Cl2], demonstrated very similar cytotoxicity profiles. [Rh(η5-C5Me5)(pta)Cl2] proved significantly more cytotoxic in A549 cells and [Rh(η5-C5Me5)(pta)2Cl]Cl 3-fold more cytotoxic in T47D cells, both relative to RAPTA-C. These data suggest that the development of organometallic anticancer drugs based on the neighboring elements to ruthenium should not be overlooked." @default.
- W2040593990 created "2016-06-24" @default.
- W2040593990 creator A5006082492 @default.
- W2040593990 creator A5008742957 @default.
- W2040593990 creator A5017214018 @default.
- W2040593990 creator A5017779506 @default.
- W2040593990 creator A5035889203 @default.
- W2040593990 creator A5044433603 @default.
- W2040593990 creator A5070279486 @default.
- W2040593990 creator A5073940467 @default.
- W2040593990 creator A5075243413 @default.
- W2040593990 creator A5078072008 @default.
- W2040593990 date "2006-07-13" @default.
- W2040593990 modified "2023-10-10" @default.
- W2040593990 title "In Vitro Evaluation of Rhodium and Osmium RAPTA Analogues: The Case for Organometallic Anticancer Drugs Not Based on Ruthenium" @default.
- W2040593990 cites W1511491270 @default.
- W2040593990 cites W1901964961 @default.
- W2040593990 cites W1967517956 @default.
- W2040593990 cites W1967552331 @default.
- W2040593990 cites W1967651337 @default.
- W2040593990 cites W1973904605 @default.
- W2040593990 cites W1974693247 @default.
- W2040593990 cites W1975661300 @default.
- W2040593990 cites W1978516732 @default.
- W2040593990 cites W1980411311 @default.
- W2040593990 cites W1996102555 @default.
- W2040593990 cites W1996734790 @default.
- W2040593990 cites W2004262869 @default.
- W2040593990 cites W2013962480 @default.
- W2040593990 cites W2014525894 @default.
- W2040593990 cites W2014588550 @default.
- W2040593990 cites W2016408785 @default.
- W2040593990 cites W2018547243 @default.
- W2040593990 cites W2023886320 @default.
- W2040593990 cites W2038952957 @default.
- W2040593990 cites W2039000017 @default.
- W2040593990 cites W2040395507 @default.
- W2040593990 cites W2045200945 @default.
- W2040593990 cites W2045318615 @default.
- W2040593990 cites W2046374910 @default.
- W2040593990 cites W2048168597 @default.
- W2040593990 cites W2050016181 @default.
- W2040593990 cites W2050077837 @default.
- W2040593990 cites W2059020082 @default.
- W2040593990 cites W2059583857 @default.
- W2040593990 cites W2060391323 @default.
- W2040593990 cites W2062198538 @default.
- W2040593990 cites W2063832187 @default.
- W2040593990 cites W2064586647 @default.
- W2040593990 cites W2075516453 @default.
- W2040593990 cites W2075699065 @default.
- W2040593990 cites W2077328494 @default.
- W2040593990 cites W2079282056 @default.
- W2040593990 cites W2080451532 @default.
- W2040593990 cites W2087275525 @default.
- W2040593990 cites W2119338352 @default.
- W2040593990 cites W2129213133 @default.
- W2040593990 cites W2130610061 @default.
- W2040593990 cites W2140895245 @default.
- W2040593990 cites W2145902785 @default.
- W2040593990 cites W2146687709 @default.
- W2040593990 cites W2166689829 @default.
- W2040593990 cites W2170756410 @default.
- W2040593990 cites W2328494541 @default.
- W2040593990 cites W2401335010 @default.
- W2040593990 cites W271398347 @default.
- W2040593990 cites W626830703 @default.
- W2040593990 doi "https://doi.org/10.1021/om060394o" @default.
- W2040593990 hasPublicationYear "2006" @default.
- W2040593990 type Work @default.
- W2040593990 sameAs 2040593990 @default.
- W2040593990 citedByCount "173" @default.
- W2040593990 countsByYear W20405939902012 @default.
- W2040593990 countsByYear W20405939902013 @default.
- W2040593990 countsByYear W20405939902014 @default.
- W2040593990 countsByYear W20405939902015 @default.
- W2040593990 countsByYear W20405939902016 @default.
- W2040593990 countsByYear W20405939902017 @default.
- W2040593990 countsByYear W20405939902018 @default.
- W2040593990 countsByYear W20405939902019 @default.
- W2040593990 countsByYear W20405939902020 @default.
- W2040593990 countsByYear W20405939902021 @default.
- W2040593990 countsByYear W20405939902022 @default.
- W2040593990 countsByYear W20405939902023 @default.
- W2040593990 crossrefType "journal-article" @default.
- W2040593990 hasAuthorship W2040593990A5006082492 @default.
- W2040593990 hasAuthorship W2040593990A5008742957 @default.
- W2040593990 hasAuthorship W2040593990A5017214018 @default.
- W2040593990 hasAuthorship W2040593990A5017779506 @default.
- W2040593990 hasAuthorship W2040593990A5035889203 @default.
- W2040593990 hasAuthorship W2040593990A5044433603 @default.
- W2040593990 hasAuthorship W2040593990A5070279486 @default.
- W2040593990 hasAuthorship W2040593990A5073940467 @default.
- W2040593990 hasAuthorship W2040593990A5075243413 @default.
- W2040593990 hasAuthorship W2040593990A5078072008 @default.
- W2040593990 hasConcept C155647269 @default.
- W2040593990 hasConcept C161790260 @default.
- W2040593990 hasConcept C178790620 @default.