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- W2040594561 abstract "G A A b st ra ct s RS ≥2 had a significantly higher level of anti-TNF. The differences between those with RS of i0-i1 and those with a RS ≥ i2 are shown in Table 1. Those patients with a RS ≥ i2 were more likely to have anti-TNF antibodies (p<0.01) and undetectable drug levels (p=0.03). The area under the curve on the association between a RS ≥ i2 and anti-TNF levels was 0.84 (p=0.011). 6 (21%) and 16 (55%) had stenosis at the level of the anastomosis and microscopically active disease, respectively. Lower drug levels were predictive of microscopic disease activity in the anastomosis (ROC: 0.74, p=0.02) but not for stenosis of the anastomosis (ROC: 0.71, p=0.13). CONCLUSIONS Low anti-TNF drug levels and the presence of antidrug antibodies were associated with endoscopically-significant disease recurrence after surgery for Crohn's. Monitoring anti-TNF drug levels in patients receiving these drugs for postoperative prevention may be useful in proactively minimizing disease recurrence. Table 1: Comparison of those patients found to have a Rutgeerts i0-i1 to those with a i2-i4" @default.
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- W2040594561 date "2014-05-01" @default.
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- W2040594561 title "Sa1254 Anti-Tumor Necrosis Factor Levels Are Not Associated With Intestinal Extent of Mucosal Inflammation in Patients With Inflammatory Bowel Diseases" @default.
- W2040594561 doi "https://doi.org/10.1016/s0016-5085(14)60858-1" @default.
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