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- W2040594672 abstract "This chapter discusses the morphological organization, biochemistry, and development of the brush-border cytoskeleton. The absorptive cell of the intestinal epithelium is a highly polarized columnar cell 20μm in height whose chief function is the transport of nutrients. The absorptive cells, along with the mucus-secreting goblet cells and a few other specific cell types, form a simple epithelium in the shape of ∼2mm in length macroscopic finger-like or paddle-shaped villi. Nutrient transport is facilitated by the fact that the luminal, or apical, plasma membrane is infolded into more than a thousand finger-like microvilli, 1.5–2μm in length. Not only is cell shape asymmetric, but the protein distribution of the plasma membrane is polarized with many transport enzymes localized to the apical membrane whose domain remains separate from the basolateral membrane, itself containing unique proteins, by extensive tight junctions. Within microvilli, and providing their structural support, is a core of 10–50 actin microfilaments that are extensively cross-linked to one another and to the overlying plasma membrane." @default.
- W2040594672 created "2016-06-24" @default.
- W2040594672 creator A5022509828 @default.
- W2040594672 date "1987-01-01" @default.
- W2040594672 modified "2023-10-18" @default.
- W2040594672 title "The Brush Border: A Model for Structure, Biochemistry, Motility, and Assembly of the Cytoskeleton" @default.
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