FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040595955> ?p ?o ?g. }

• W2040595955 endingPage "104" @default.
• W2040595955 startingPage "99" @default.
• W2040595955 abstract "To compare the use of reverse transcriptase polymerase chain reaction (RT-PCR) with that of morphology-based methods for diagnosis, staging, and detection of metastatic disease in pediatric alveolar rhabdomyosarcoma (ARMS), Ewing sarcoma family of tumors (ESFT), and desmoplastic small round cell tumors (DSRCT).RT-PCR assays for the EWS-FLII, EWS-ERG, PAX3-FKHR, PAX7-FKHR, and EWS-WTI fusion transcripts were performed on RNA extracted from the primary tumor tissue, bone marrow, and body fluids obtained at initial presentation and relapse. Molecular findings were compared with original histologic diagnoses and results of staging procedures.Eighty-eight samples from 47 patients with ARMS (n = 13), ESFT (n = 31), or DSRCT (n = 3) were analyzed. The detection rate of metastatic disease was significantly higher with RT-PCR (95%) as compared with the morphologic methods (70%) for the three pediatric sarcomas studied. In primary tumors with characteristic fusion transcript, RT-PCR was positive in all cases with morphologic evidence of metastatic disease. Moreover, in six patients (3 with ARMS, 2 with DSRCT, and 1 with ESFT) with metastatic disease, micrometastases in bone marrow (4) and other sites (2) were detected by RT-PCR alone. Importantly, none of the patients with localized disease diagnosed had micrometastases detected by RT-PCR in bone marrow.The high sensitivity and specificity of RT-PCR for the characteristic fusion transcripts of pediatric sarcomas make it an ideal method to aid in the routine staging of these patients. In addition, the 100% sensitivity of RT-PCR in detection of micrometastasis makes it useful for follow-up and detection of minimal residual disease. However, the clinical significance of molecularly-detectable disease remains unknown. Further studies should aim to elucidate the therapeutic and prognostic implications of micrometastases detected by RT-PCR alone." @default.
• W2040595955 created "2016-06-24" @default.
• W2040595955 creator A5009480626 @default.
• W2040595955 creator A5015143631 @default.
• W2040595955 creator A5029461308 @default.
• W2040595955 creator A5043512211 @default.
• W2040595955 creator A5046880941 @default.
• W2040595955 creator A5048306141 @default.
• W2040595955 creator A5051234026 @default.
• W2040595955 date "2001-02-01" @default.
• W2040595955 modified "2023-10-14" @default.
• W2040595955 title "Use of Reverse Transcriptase Polymerase Chain Reaction for Diagnosis and Staging of Alveolar Rhabdomyosarcoma, Ewing Sarcoma Family of Tumors, and Desmoplastic Small Round Cell Tumor" @default.
• W2040595955 cites W115673842 @default.
• W2040595955 cites W1693048258 @default.
• W2040595955 cites W1916122294 @default.
• W2040595955 cites W1996121905 @default.
• W2040595955 cites W1997680695 @default.
• W2040595955 cites W1998591052 @default.
• W2040595955 cites W2007280125 @default.
• W2040595955 cites W2012485638 @default.
• W2040595955 cites W2023247726 @default.
• W2040595955 cites W2025527937 @default.
• W2040595955 cites W2045919099 @default.
• W2040595955 cites W2053204059 @default.
• W2040595955 cites W2078025588 @default.
• W2040595955 cites W2259253088 @default.
• W2040595955 cites W2313571988 @default.
• W2040595955 cites W2317345315 @default.
• W2040595955 cites W2317783677 @default.
• W2040595955 cites W4234913325 @default.
• W2040595955 doi "https://doi.org/10.1097/00043426-200102000-00006" @default.
• W2040595955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11216714" @default.
• W2040595955 hasPublicationYear "2001" @default.
• W2040595955 type Work @default.
• W2040595955 sameAs 2040595955 @default.
• W2040595955 citedByCount "60" @default.
• W2040595955 countsByYear W20405959552012 @default.
• W2040595955 countsByYear W20405959552013 @default.
• W2040595955 countsByYear W20405959552014 @default.
• W2040595955 countsByYear W20405959552015 @default.
• W2040595955 countsByYear W20405959552016 @default.
• W2040595955 countsByYear W20405959552017 @default.
• W2040595955 countsByYear W20405959552019 @default.
• W2040595955 crossrefType "journal-article" @default.
• W2040595955 hasAuthorship W2040595955A5009480626 @default.
• W2040595955 hasAuthorship W2040595955A5015143631 @default.
• W2040595955 hasAuthorship W2040595955A5029461308 @default.
• W2040595955 hasAuthorship W2040595955A5043512211 @default.
• W2040595955 hasAuthorship W2040595955A5046880941 @default.
• W2040595955 hasAuthorship W2040595955A5048306141 @default.
• W2040595955 hasAuthorship W2040595955A5051234026 @default.
• W2040595955 hasConcept C104317684 @default.
• W2040595955 hasConcept C111829193 @default.
• W2040595955 hasConcept C121608353 @default.
• W2040595955 hasConcept C126322002 @default.
• W2040595955 hasConcept C142724271 @default.
• W2040595955 hasConcept C150194340 @default.
• W2040595955 hasConcept C156719811 @default.
• W2040595955 hasConcept C2776522094 @default.
• W2040595955 hasConcept C2778123414 @default.
• W2040595955 hasConcept C2778256501 @default.
• W2040595955 hasConcept C2778274637 @default.
• W2040595955 hasConcept C2779013556 @default.
• W2040595955 hasConcept C2779823535 @default.
• W2040595955 hasConcept C2780007613 @default.
• W2040595955 hasConcept C2780844630 @default.
• W2040595955 hasConcept C4692481 @default.
• W2040595955 hasConcept C49105822 @default.
• W2040595955 hasConcept C55493867 @default.
• W2040595955 hasConcept C71924100 @default.
• W2040595955 hasConcept C86803240 @default.
• W2040595955 hasConceptScore W2040595955C104317684 @default.
• W2040595955 hasConceptScore W2040595955C111829193 @default.
• W2040595955 hasConceptScore W2040595955C121608353 @default.
• W2040595955 hasConceptScore W2040595955C126322002 @default.
• W2040595955 hasConceptScore W2040595955C142724271 @default.
• W2040595955 hasConceptScore W2040595955C150194340 @default.
• W2040595955 hasConceptScore W2040595955C156719811 @default.
• W2040595955 hasConceptScore W2040595955C2776522094 @default.
• W2040595955 hasConceptScore W2040595955C2778123414 @default.
• W2040595955 hasConceptScore W2040595955C2778256501 @default.
• W2040595955 hasConceptScore W2040595955C2778274637 @default.
• W2040595955 hasConceptScore W2040595955C2779013556 @default.
• W2040595955 hasConceptScore W2040595955C2779823535 @default.
• W2040595955 hasConceptScore W2040595955C2780007613 @default.
• W2040595955 hasConceptScore W2040595955C2780844630 @default.
• W2040595955 hasConceptScore W2040595955C4692481 @default.
• W2040595955 hasConceptScore W2040595955C49105822 @default.
• W2040595955 hasConceptScore W2040595955C55493867 @default.
• W2040595955 hasConceptScore W2040595955C71924100 @default.
• W2040595955 hasConceptScore W2040595955C86803240 @default.
• W2040595955 hasIssue "2" @default.
• W2040595955 hasLocation W20405959551 @default.
• W2040595955 hasLocation W20405959552 @default.
• W2040595955 hasOpenAccess W2040595955 @default.
• W2040595955 hasPrimaryLocation W20405959551 @default.
• W2040595955 hasRelatedWork W2003632667 @default.
• W2040595955 hasRelatedWork W2074592271 @default.

• next