FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040603927> ?p ?o ?g. }

• W2040603927 endingPage "397" @default.
• W2040603927 startingPage "390" @default.
• W2040603927 abstract "HER2 (human epidermal growth factor receptor 2) is overexpressed in 15 to 20% of breast cancer. Anti-HER2 targeted therapies, notably trastuzumab, have transformed the natural history of this disease. Trastuzumab emtansine, consisting of trastuzumab coupled to a cytotoxic agent, emtansine (DM1), by a stable linker, has been approved in November 2013 by the European Medicine Agency. Trastuzumab emtansine targets and inhibits HER2 signaling, but also allows emtansine to be directly delivered inside HER2-positive cancer cells. It is indicated as single-agent in taxane and trastuzumab-pretreated HER2-positive breast cancer patients with metastatic and locally recurrent unresecable disease or relapsing within 6 months of the end of adjuvant therapy. This indication is based on the results of the EMILIA study, an open label phase III randomized trial comparing trastuzumab emtansine to lapatinib-capecitabine. The two primary endpoints were reached. The progression-free survival was 6.4 months in the lapatinib-capecitabine arm versus 9.6 months for the trastuzumab emtansine arm (HR=0.65; 95% CI=0.55-0.77, P<0.001). Overall survival at the second interim analysis was 25.1 months in the lapatinib-capecitabine arm versus 30.9 months in the trastuzumab emtansine arm (HR=0.68; 95% CI=0.55-0.85, P<0.001). Moreover, adverse events were more frequent in the lapatinib-capecitabine arm." @default.
• W2040603927 created "2016-06-24" @default.
• W2040603927 creator A5006642161 @default.
• W2040603927 creator A5011899504 @default.
• W2040603927 creator A5014533663 @default.
• W2040603927 date "2015-04-01" @default.
• W2040603927 modified "2023-10-16" @default.
• W2040603927 title "Autorisation de mise sur le marché du trastuzumab emtansine (Kadcyla®) dans les cancers du sein métastatiques HER2-positifs" @default.
• W2040603927 cites W1909178615 @default.
• W2040603927 cites W1968590850 @default.
• W2040603927 cites W1971738718 @default.
• W2040603927 cites W1984007340 @default.
• W2040603927 cites W1987958750 @default.
• W2040603927 cites W2001447115 @default.
• W2040603927 cites W2004783782 @default.
• W2040603927 cites W2014457594 @default.
• W2040603927 cites W2021019188 @default.
• W2040603927 cites W2023681515 @default.
• W2040603927 cites W2024651005 @default.
• W2040603927 cites W2035825064 @default.
• W2040603927 cites W2037266556 @default.
• W2040603927 cites W2043970203 @default.
• W2040603927 cites W2059411043 @default.
• W2040603927 cites W2080518844 @default.
• W2040603927 cites W2094477446 @default.
• W2040603927 cites W2098544382 @default.
• W2040603927 cites W2110444464 @default.
• W2040603927 cites W2114282952 @default.
• W2040603927 cites W2115100262 @default.
• W2040603927 cites W2120627364 @default.
• W2040603927 cites W2128402413 @default.
• W2040603927 cites W2136527721 @default.
• W2040603927 cites W2137086207 @default.
• W2040603927 cites W2139248078 @default.
• W2040603927 cites W2141393790 @default.
• W2040603927 cites W2141546964 @default.
• W2040603927 cites W2156677665 @default.
• W2040603927 cites W2159967578 @default.
• W2040603927 cites W2170241131 @default.
• W2040603927 cites W4244008531 @default.
• W2040603927 doi "https://doi.org/10.1016/j.bulcan.2015.02.007" @default.
• W2040603927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25790739" @default.
• W2040603927 hasPublicationYear "2015" @default.
• W2040603927 type Work @default.
• W2040603927 sameAs 2040603927 @default.
• W2040603927 citedByCount "12" @default.
• W2040603927 countsByYear W20406039272016 @default.
• W2040603927 countsByYear W20406039272017 @default.
• W2040603927 countsByYear W20406039272018 @default.
• W2040603927 countsByYear W20406039272019 @default.
• W2040603927 countsByYear W20406039272020 @default.
• W2040603927 countsByYear W20406039272021 @default.
• W2040603927 countsByYear W20406039272023 @default.
• W2040603927 crossrefType "journal-article" @default.
• W2040603927 hasAuthorship W2040603927A5006642161 @default.
• W2040603927 hasAuthorship W2040603927A5011899504 @default.
• W2040603927 hasAuthorship W2040603927A5014533663 @default.
• W2040603927 hasConcept C121608353 @default.
• W2040603927 hasConcept C126322002 @default.
• W2040603927 hasConcept C143998085 @default.
• W2040603927 hasConcept C197934379 @default.
• W2040603927 hasConcept C2775930923 @default.
• W2040603927 hasConcept C2777329042 @default.
• W2040603927 hasConcept C2777511904 @default.
• W2040603927 hasConcept C2777909004 @default.
• W2040603927 hasConcept C2778087150 @default.
• W2040603927 hasConcept C2779786085 @default.
• W2040603927 hasConcept C526805850 @default.
• W2040603927 hasConcept C530470458 @default.
• W2040603927 hasConcept C71924100 @default.
• W2040603927 hasConceptScore W2040603927C121608353 @default.
• W2040603927 hasConceptScore W2040603927C126322002 @default.
• W2040603927 hasConceptScore W2040603927C143998085 @default.
• W2040603927 hasConceptScore W2040603927C197934379 @default.
• W2040603927 hasConceptScore W2040603927C2775930923 @default.
• W2040603927 hasConceptScore W2040603927C2777329042 @default.
• W2040603927 hasConceptScore W2040603927C2777511904 @default.
• W2040603927 hasConceptScore W2040603927C2777909004 @default.
• W2040603927 hasConceptScore W2040603927C2778087150 @default.
• W2040603927 hasConceptScore W2040603927C2779786085 @default.
• W2040603927 hasConceptScore W2040603927C526805850 @default.
• W2040603927 hasConceptScore W2040603927C530470458 @default.
• W2040603927 hasConceptScore W2040603927C71924100 @default.
• W2040603927 hasIssue "4" @default.
• W2040603927 hasLocation W20406039271 @default.
• W2040603927 hasLocation W20406039272 @default.
• W2040603927 hasOpenAccess W2040603927 @default.
• W2040603927 hasPrimaryLocation W20406039271 @default.
• W2040603927 hasRelatedWork W2012784647 @default.
• W2040603927 hasRelatedWork W2085871826 @default.
• W2040603927 hasRelatedWork W2088304505 @default.
• W2040603927 hasRelatedWork W2188843871 @default.
• W2040603927 hasRelatedWork W2902290189 @default.
• W2040603927 hasRelatedWork W3083051559 @default.
• W2040603927 hasRelatedWork W3088751691 @default.
• W2040603927 hasRelatedWork W3111112888 @default.
• W2040603927 hasRelatedWork W4206299960 @default.
• W2040603927 hasRelatedWork W4221053062 @default.

• next