FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040607009> ?p ?o ?g. }

• W2040607009 endingPage "17354" @default.
• W2040607009 startingPage "17349" @default.
• W2040607009 abstract "The class II transactivator (CIITA) is the master integrator of expression of MHC class II genes. It interacts with variety of basal transcription factors to initiate and elongate transcription of these genes. Among others, it recruits positive transcription elongation factor b (P-TEFb) to MHC class II promoters. In cells, P-TEFb is found in small active or large inactive complexes. The large complex is composed of P-TEFb, 7SK small nuclear RNA, and hexamethylene bisacetamide-inducible protein 1 (Hexim1). The present study identifies Hexim1 as a potent inhibitor of CIITA-mediated transcription. Not only the exogenously expressed but also IFN-γ-induced CIITA was inhibited by Hexim1. This inhibition did not result from an association between Hexim1 and CIITA but depended on the intact Cyclin T1-binding domain in Hexim1. Importantly, Hexim1 sequestered P-TEFb from CIITA, as documented by binding competition and ChIP assays. Conversely, the depletion of Hexim1 from cells by siRNA increased CIITA-mediated transcription. Thus, modulating ratios between active and inactive P-TEFb complexes is an additional mechanism of regulating transcriptional activators such as CIITA." @default.
• W2040607009 created "2016-06-24" @default.
• W2040607009 creator A5002677870 @default.
• W2040607009 creator A5063847262 @default.
• W2040607009 creator A5070916977 @default.
• W2040607009 date "2006-11-14" @default.
• W2040607009 modified "2023-09-27" @default.
• W2040607009 title "Hexim1 sequesters positive transcription elongation factor b from the class II transactivator on MHC class II promoters" @default.
• W2040607009 cites W10039931 @default.
• W2040607009 cites W1550072509 @default.
• W2040607009 cites W1552734188 @default.
• W2040607009 cites W1605366962 @default.
• W2040607009 cites W1676133928 @default.
• W2040607009 cites W1824777900 @default.
• W2040607009 cites W1886270478 @default.
• W2040607009 cites W1920211008 @default.
• W2040607009 cites W1977121504 @default.
• W2040607009 cites W1996894556 @default.
• W2040607009 cites W2001859214 @default.
• W2040607009 cites W2011015935 @default.
• W2040607009 cites W2012326746 @default.
• W2040607009 cites W2012425092 @default.
• W2040607009 cites W2017188699 @default.
• W2040607009 cites W2021420308 @default.
• W2040607009 cites W2022936085 @default.
• W2040607009 cites W2028691831 @default.
• W2040607009 cites W2032025865 @default.
• W2040607009 cites W2033181127 @default.
• W2040607009 cites W2038192505 @default.
• W2040607009 cites W2045090138 @default.
• W2040607009 cites W2047339163 @default.
• W2040607009 cites W2049170267 @default.
• W2040607009 cites W2082815099 @default.
• W2040607009 cites W2089529796 @default.
• W2040607009 cites W2090649292 @default.
• W2040607009 cites W2092340900 @default.
• W2040607009 cites W2092381804 @default.
• W2040607009 cites W2094420876 @default.
• W2040607009 cites W2111815169 @default.
• W2040607009 cites W2122187426 @default.
• W2040607009 cites W2127324678 @default.
• W2040607009 cites W2128810491 @default.
• W2040607009 cites W2129738605 @default.
• W2040607009 cites W2133101307 @default.
• W2040607009 cites W2150217938 @default.
• W2040607009 cites W2153079626 @default.
• W2040607009 cites W2155212300 @default.
• W2040607009 cites W2160361343 @default.
• W2040607009 cites W2162914583 @default.
• W2040607009 doi "https://doi.org/10.1073/pnas.0603079103" @default.
• W2040607009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1859933" @default.
• W2040607009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17088550" @default.
• W2040607009 hasPublicationYear "2006" @default.
• W2040607009 type Work @default.
• W2040607009 sameAs 2040607009 @default.
• W2040607009 citedByCount "16" @default.
• W2040607009 countsByYear W20406070092016 @default.
• W2040607009 countsByYear W20406070092019 @default.
• W2040607009 countsByYear W20406070092022 @default.
• W2040607009 crossrefType "journal-article" @default.
• W2040607009 hasAuthorship W2040607009A5002677870 @default.
• W2040607009 hasAuthorship W2040607009A5063847262 @default.
• W2040607009 hasAuthorship W2040607009A5070916977 @default.
• W2040607009 hasBestOaLocation W20406070091 @default.
• W2040607009 hasConcept C101762097 @default.
• W2040607009 hasConcept C104317684 @default.
• W2040607009 hasConcept C1292079 @default.
• W2040607009 hasConcept C138885662 @default.
• W2040607009 hasConcept C144825837 @default.
• W2040607009 hasConcept C150194340 @default.
• W2040607009 hasConcept C153911025 @default.
• W2040607009 hasConcept C172768829 @default.
• W2040607009 hasConcept C179926584 @default.
• W2040607009 hasConcept C185592680 @default.
• W2040607009 hasConcept C207936829 @default.
• W2040607009 hasConcept C2775890610 @default.
• W2040607009 hasConcept C2777841055 @default.
• W2040607009 hasConcept C2778814158 @default.
• W2040607009 hasConcept C41895202 @default.
• W2040607009 hasConcept C502942594 @default.
• W2040607009 hasConcept C54355233 @default.
• W2040607009 hasConcept C64350747 @default.
• W2040607009 hasConcept C86339819 @default.
• W2040607009 hasConcept C86803240 @default.
• W2040607009 hasConcept C95444343 @default.
• W2040607009 hasConceptScore W2040607009C101762097 @default.
• W2040607009 hasConceptScore W2040607009C104317684 @default.
• W2040607009 hasConceptScore W2040607009C1292079 @default.
• W2040607009 hasConceptScore W2040607009C138885662 @default.
• W2040607009 hasConceptScore W2040607009C144825837 @default.
• W2040607009 hasConceptScore W2040607009C150194340 @default.
• W2040607009 hasConceptScore W2040607009C153911025 @default.
• W2040607009 hasConceptScore W2040607009C172768829 @default.
• W2040607009 hasConceptScore W2040607009C179926584 @default.
• W2040607009 hasConceptScore W2040607009C185592680 @default.
• W2040607009 hasConceptScore W2040607009C207936829 @default.
• W2040607009 hasConceptScore W2040607009C2775890610 @default.
• W2040607009 hasConceptScore W2040607009C2777841055 @default.

• next