FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040607511> ?p ?o ?g. }

• W2040607511 endingPage "242" @default.
• W2040607511 startingPage "233" @default.
• W2040607511 abstract "Recently, we have demonstrated in rainbow trout that environmental temperature may, independently of nutritional status, directly stimulate plasma growth hormone (GH) that is recognised as being an insulin-like growth factor (IGF) system regulator. The aim of this study was to determine whether temperature may directly regulate the IGF system or indirectly regulate it through plasma GH or nutritional status. For this purpose, rainbow trout were reared at 8, 12, or 16 degrees C and fed either ad libitum (similar nutritional status) to evidence the global effect of temperature, or with the same ration (1.2% body weight/day), to determine the temperature effect in fish with the same growth rate. Endocrine and autocrine/paracrine regulations of the IGF system were determined by measuring plasma IGF1 and IGF2, liver and muscle IGF1 and IGF2 mRNA as well as IGFRIa, IGFRIb mRNA, and the quantity of IGF type I receptor in muscle. Our results show that neither rearing temperature nor the nutritional status of fish affected the expression of both IGF receptor genes in muscle. Nevertheless, the quantity of IGF type I receptor determined by a binding study, appeared to be inversely proportional (P<0.05) to the rearing temperature without any relationship with nutritional status, suggesting a direct effect of temperature on its turnover. After 2 weeks of treatment, the levels of IGF1 mRNA in muscle at 8 degrees C were 2-fold higher (P<0.05) than at 16 degrees C in both ad libitum and restricted feed fish, whereas after 6 weeks, this difference was no longer observed. In both experiments, the levels of plasma IGF2 were 10-fold higher than the levels of plasma IGF1 (mean 105+/-3.0 versus 13.5+/-0.6 ng/ml), and plasma levels were correlated with their respective mRNA liver concentrations (r2=0.14 and 0.25, respectively; P<0.01). In the ad libitum feeding experiment, plasma and mRNA levels of IGF1 were related to the rearing temperature (P<0.05), while for IGF2 no effect was seen. In contrast, in the restricted feeding experiment, plasma and IGF2 mRNA levels were inversely proportional to the rearing temperature (P<0.0001) while plasma IGF1 was unaltered. Levels of plasma IGF1 were related to the growth rate in both experiments, while levels of plasma IGF2 appeared to be associated with the nutritional status of the fish. Our results suggest that the autocrine/paracrine expression of IGF1 and IGF2 in muscle is not a key regulator of the growth promoting effect of temperature. Conversely, temperature seems to promote growth through IGF1 secretion by the liver following GH stimulation, and impairment of nutritional status would prevent the IGF1 stimulation by temperature. In addition, the growth-promoting effect of temperature did not affect plasma IGF2, which appeared to be more related to the metabolic status of the fish." @default.
• W2040607511 created "2016-06-24" @default.
• W2040607511 creator A5006030183 @default.
• W2040607511 creator A5008112245 @default.
• W2040607511 creator A5028181198 @default.
• W2040607511 creator A5043236697 @default.
• W2040607511 creator A5058603927 @default.
• W2040607511 creator A5071406356 @default.
• W2040607511 date "2003-09-01" @default.
• W2040607511 modified "2023-10-02" @default.
• W2040607511 title "Effects of environmental temperature on IGF1, IGF2, and IGF type I receptor expression in rainbow trout (Oncorhynchus mykiss)" @default.
• W2040607511 cites W1599550744 @default.
• W2040607511 cites W1965756301 @default.
• W2040607511 cites W1969036078 @default.
• W2040607511 cites W1969650180 @default.
• W2040607511 cites W1971849677 @default.
• W2040607511 cites W1972525349 @default.
• W2040607511 cites W1983688242 @default.
• W2040607511 cites W1987627970 @default.
• W2040607511 cites W1991849653 @default.
• W2040607511 cites W1993290931 @default.
• W2040607511 cites W2010253967 @default.
• W2040607511 cites W2014418366 @default.
• W2040607511 cites W2019201230 @default.
• W2040607511 cites W2023994782 @default.
• W2040607511 cites W2028224609 @default.
• W2040607511 cites W2039286948 @default.
• W2040607511 cites W2042136445 @default.
• W2040607511 cites W2058340484 @default.
• W2040607511 cites W2060074511 @default.
• W2040607511 cites W2061031951 @default.
• W2040607511 cites W2062151411 @default.
• W2040607511 cites W2064827167 @default.
• W2040607511 cites W2067405660 @default.
• W2040607511 cites W2070268138 @default.
• W2040607511 cites W2072941542 @default.
• W2040607511 cites W2081075932 @default.
• W2040607511 cites W2092259056 @default.
• W2040607511 cites W2094998385 @default.
• W2040607511 cites W2095249793 @default.
• W2040607511 cites W2096040432 @default.
• W2040607511 cites W2106920798 @default.
• W2040607511 cites W2121484931 @default.
• W2040607511 cites W2135742794 @default.
• W2040607511 cites W2138338566 @default.
• W2040607511 cites W2307036579 @default.
• W2040607511 cites W255353249 @default.
• W2040607511 cites W4232639695 @default.
• W2040607511 doi "https://doi.org/10.1016/s0016-6480(03)00167-9" @default.
• W2040607511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12928012" @default.
• W2040607511 hasPublicationYear "2003" @default.
• W2040607511 type Work @default.
• W2040607511 sameAs 2040607511 @default.
• W2040607511 citedByCount "118" @default.
• W2040607511 countsByYear W20406075112012 @default.
• W2040607511 countsByYear W20406075112013 @default.
• W2040607511 countsByYear W20406075112014 @default.
• W2040607511 countsByYear W20406075112015 @default.
• W2040607511 countsByYear W20406075112016 @default.
• W2040607511 countsByYear W20406075112017 @default.
• W2040607511 countsByYear W20406075112018 @default.
• W2040607511 countsByYear W20406075112019 @default.
• W2040607511 countsByYear W20406075112020 @default.
• W2040607511 countsByYear W20406075112021 @default.
• W2040607511 countsByYear W20406075112022 @default.
• W2040607511 countsByYear W20406075112023 @default.
• W2040607511 crossrefType "journal-article" @default.
• W2040607511 hasAuthorship W2040607511A5006030183 @default.
• W2040607511 hasAuthorship W2040607511A5008112245 @default.
• W2040607511 hasAuthorship W2040607511A5028181198 @default.
• W2040607511 hasAuthorship W2040607511A5043236697 @default.
• W2040607511 hasAuthorship W2040607511A5058603927 @default.
• W2040607511 hasAuthorship W2040607511A5071406356 @default.
• W2040607511 hasConcept C104317684 @default.
• W2040607511 hasConcept C105580179 @default.
• W2040607511 hasConcept C113675107 @default.
• W2040607511 hasConcept C126322002 @default.
• W2040607511 hasConcept C128240485 @default.
• W2040607511 hasConcept C134018914 @default.
• W2040607511 hasConcept C170493617 @default.
• W2040607511 hasConcept C2775960820 @default.
• W2040607511 hasConcept C2780689927 @default.
• W2040607511 hasConcept C2909208804 @default.
• W2040607511 hasConcept C2984496839 @default.
• W2040607511 hasConcept C2994167347 @default.
• W2040607511 hasConcept C505870484 @default.
• W2040607511 hasConcept C55493867 @default.
• W2040607511 hasConcept C71315377 @default.
• W2040607511 hasConcept C71924100 @default.
• W2040607511 hasConcept C7876069 @default.
• W2040607511 hasConcept C86803240 @default.
• W2040607511 hasConceptScore W2040607511C104317684 @default.
• W2040607511 hasConceptScore W2040607511C105580179 @default.
• W2040607511 hasConceptScore W2040607511C113675107 @default.
• W2040607511 hasConceptScore W2040607511C126322002 @default.
• W2040607511 hasConceptScore W2040607511C128240485 @default.
• W2040607511 hasConceptScore W2040607511C134018914 @default.
• W2040607511 hasConceptScore W2040607511C170493617 @default.

• next