FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040607554> ?p ?o ?g. }

• W2040607554 endingPage "130" @default.
• W2040607554 startingPage "122" @default.
• W2040607554 abstract "Prostate cancer is one of the leading causes of cancer related death in men, and remains incurable in the metastatic setting. Despite the initial response to androgen deprivation, the disease gradually progresses to a hormone-refractory state due to cumulative genetic alterations in tumour cells or the microenvironment. Docetaxel represents the first chemotherapeutic agent with a small survival benefit for metastatic hormone-refractory prostate cancer (HRPC). In an attempt to improve survival benefit, several novel drugs targeting specific pathways involved in cell signaling, proliferation, angiogenesis, apoptosis and immune modulation are currently under investigation either as single agents or in combination with cytotoxic drugs. Clinical trials evaluate the inhibition of prostate cancer cells growth by targeting the nuclear receptor of vitamin D alongside cytotoxic therapy. Angiogenesis inhibitors as well as epidermal growth factor receptor blockage are also under clinical investigation in several combinations. Immunomodulatory agents and autologous dendritic cells or allogenic whole cell vaccines have progressed up to phase III trials. New drugs targeting bone microenvironment or apoptotic and proliferation pathways may enhance antitumour activity of chemotherapy in HRCP. Given the complexity of mechanisms underlying prostate cancer progression, future therapeutic strategies should rely on multidisciplinary approaches, thus exploiting newer molecular targets in concert with immunotherapy and cytotoxic chemotherapy. Here, we review the latest clinical evidence regarding the use of novel agents in HRPC." @default.
• W2040607554 created "2016-06-24" @default.
• W2040607554 creator A5034623304 @default.
• W2040607554 creator A5049509860 @default.
• W2040607554 creator A5089854900 @default.
• W2040607554 date "2010-04-01" @default.
• W2040607554 modified "2023-10-16" @default.
• W2040607554 title "Targeted therapeutic approaches for hormone-refractory prostate cancer" @default.
• W2040607554 cites W1879747226 @default.
• W2040607554 cites W1893347245 @default.
• W2040607554 cites W1967200208 @default.
• W2040607554 cites W1986266121 @default.
• W2040607554 cites W1988698591 @default.
• W2040607554 cites W1991148746 @default.
• W2040607554 cites W2001771356 @default.
• W2040607554 cites W2003985632 @default.
• W2040607554 cites W2004624656 @default.
• W2040607554 cites W2016548090 @default.
• W2040607554 cites W2023659903 @default.
• W2040607554 cites W2024149505 @default.
• W2040607554 cites W2033538744 @default.
• W2040607554 cites W2033773245 @default.
• W2040607554 cites W2034710772 @default.
• W2040607554 cites W2036083286 @default.
• W2040607554 cites W2038035925 @default.
• W2040607554 cites W2042692879 @default.
• W2040607554 cites W2061837329 @default.
• W2040607554 cites W2064536538 @default.
• W2040607554 cites W2065771840 @default.
• W2040607554 cites W2066075559 @default.
• W2040607554 cites W2075427744 @default.
• W2040607554 cites W2080439368 @default.
• W2040607554 cites W2081365151 @default.
• W2040607554 cites W2081576253 @default.
• W2040607554 cites W2085632906 @default.
• W2040607554 cites W2092986324 @default.
• W2040607554 cites W2094269170 @default.
• W2040607554 cites W2099050005 @default.
• W2040607554 cites W2100304447 @default.
• W2040607554 cites W2101591679 @default.
• W2040607554 cites W2102352213 @default.
• W2040607554 cites W2106567289 @default.
• W2040607554 cites W2108189527 @default.
• W2040607554 cites W2113231967 @default.
• W2040607554 cites W2117701024 @default.
• W2040607554 cites W2120292596 @default.
• W2040607554 cites W2120703739 @default.
• W2040607554 cites W2133427241 @default.
• W2040607554 cites W2143289308 @default.
• W2040607554 cites W2144228610 @default.
• W2040607554 cites W2145803727 @default.
• W2040607554 cites W2149752186 @default.
• W2040607554 cites W2151278366 @default.
• W2040607554 cites W2153140330 @default.
• W2040607554 cites W2153540002 @default.
• W2040607554 cites W2157769714 @default.
• W2040607554 cites W2164782357 @default.
• W2040607554 cites W2164828052 @default.
• W2040607554 cites W2165136795 @default.
• W2040607554 cites W2165542862 @default.
• W2040607554 cites W2169140729 @default.
• W2040607554 cites W2170071316 @default.
• W2040607554 cites W2170887853 @default.
• W2040607554 cites W2171351296 @default.
• W2040607554 cites W2250116227 @default.
• W2040607554 cites W2261691410 @default.
• W2040607554 cites W2304927452 @default.
• W2040607554 cites W2326516413 @default.
• W2040607554 cites W2604843273 @default.
• W2040607554 doi "https://doi.org/10.1016/j.ctrv.2009.06.001" @default.
• W2040607554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20106600" @default.
• W2040607554 hasPublicationYear "2010" @default.
• W2040607554 type Work @default.
• W2040607554 sameAs 2040607554 @default.
• W2040607554 citedByCount "69" @default.
• W2040607554 countsByYear W20406075542012 @default.
• W2040607554 countsByYear W20406075542013 @default.
• W2040607554 countsByYear W20406075542014 @default.
• W2040607554 countsByYear W20406075542015 @default.
• W2040607554 countsByYear W20406075542016 @default.
• W2040607554 countsByYear W20406075542018 @default.
• W2040607554 countsByYear W20406075542019 @default.
• W2040607554 countsByYear W20406075542021 @default.
• W2040607554 countsByYear W20406075542022 @default.
• W2040607554 countsByYear W20406075542023 @default.
• W2040607554 crossrefType "journal-article" @default.
• W2040607554 hasAuthorship W2040607554A5034623304 @default.
• W2040607554 hasAuthorship W2040607554A5049509860 @default.
• W2040607554 hasAuthorship W2040607554A5089854900 @default.
• W2040607554 hasConcept C121608353 @default.
• W2040607554 hasConcept C126322002 @default.
• W2040607554 hasConcept C143998085 @default.
• W2040607554 hasConcept C154317977 @default.
• W2040607554 hasConcept C202751555 @default.
• W2040607554 hasConcept C203014093 @default.
• W2040607554 hasConcept C2776107976 @default.
• W2040607554 hasConcept C2777701055 @default.
• W2040607554 hasConcept C2780192828 @default.

• next