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• W2040608308 abstract "We study a protein-DNA target search model with explicit DNA dynamics applicable to in vitro experiments. We show that the DNA dynamics plays a crucial role for the effectiveness of protein jumps between sites distant along the DNA contour but close in 3D space. A strongly binding protein that searches by 1D sliding and jumping alone, explores the search space less redundantly when the DNA dynamics is fast on the timescale of protein jumps than in the opposite frozen DNA limit. We characterize the crossover between these limits using simulations and scaling theory. We also rationalize the slow exploration in the frozen limit as a subtle interplay between long jumps and long trapping times of the protein in islands within random DNA configurations in solution." @default.
• W2040608308 created "2016-06-24" @default.
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• W2040608308 date "2011-11-17" @default.
• W2040608308 modified "2023-10-02" @default.
• W2040608308 title "Target search on a dynamic DNA molecule" @default.
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• W2040608308 doi "https://doi.org/10.1103/physreve.84.051911" @default.
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