Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040617124> ?p ?o ?g. }
- W2040617124 endingPage "7" @default.
- W2040617124 startingPage "1" @default.
- W2040617124 abstract "The detailed mechanisms of prion-induced neurotoxicity are largely unknown. Here, we have studied the role of DNA damage caused by reactive oxygen species in a mouse scrapie model by characterizing prion disease in the ogg1−/− mutyh−/− double knockout, which is compromised in oxidative DNA base excision repair. Ogg1 initiates removal of the major oxidation product 8-oxoguanine (8-oxoG) in DNA, and Mutyh initiates removal of adenine that has been misincorporated opposite 8-oxoG. Our data show that the onset of clinical signs appeared unaffected by Mutyh and Ogg1 expression. However, the ogg1−/− mutyh−/− mice displayed a significantly shorter clinical phase of the disease. Thus, accumulation of oxidative DNA damage might be of particular importance in the terminal clinical phase of prion disease. The prion-induced pathology and lesion profile were similar between knockout mice and controls. The fragmentation pattern of protease-resistant PrP as revealed in Western blots was also identical between the groups. Our data show that the fundamentals of prion propagation and pathological manifestation are not influenced by the oxidative DNA damage repair mechanisms studied here, but that progressive accumulation of oxidative lesions may accelerate the final toxic phase of prion disease." @default.
- W2040617124 created "2016-06-24" @default.
- W2040617124 creator A5009696381 @default.
- W2040617124 creator A5013839751 @default.
- W2040617124 creator A5021161802 @default.
- W2040617124 creator A5024417004 @default.
- W2040617124 creator A5036614414 @default.
- W2040617124 creator A5048934963 @default.
- W2040617124 creator A5054067564 @default.
- W2040617124 creator A5071636149 @default.
- W2040617124 creator A5091776300 @default.
- W2040617124 date "2014-03-01" @default.
- W2040617124 modified "2023-09-23" @default.
- W2040617124 title "Accelerated clinical course of prion disease in mice compromised in repair of oxidative DNA damage" @default.
- W2040617124 cites W1879947423 @default.
- W2040617124 cites W1967602754 @default.
- W2040617124 cites W1967800794 @default.
- W2040617124 cites W1976133898 @default.
- W2040617124 cites W1979643175 @default.
- W2040617124 cites W1980825524 @default.
- W2040617124 cites W1984856280 @default.
- W2040617124 cites W1991644458 @default.
- W2040617124 cites W1994542906 @default.
- W2040617124 cites W1996579240 @default.
- W2040617124 cites W1997938990 @default.
- W2040617124 cites W2010339813 @default.
- W2040617124 cites W2013503821 @default.
- W2040617124 cites W2019216276 @default.
- W2040617124 cites W2019301423 @default.
- W2040617124 cites W2021034011 @default.
- W2040617124 cites W2022131253 @default.
- W2040617124 cites W2022993326 @default.
- W2040617124 cites W2034141196 @default.
- W2040617124 cites W2040842344 @default.
- W2040617124 cites W2049192526 @default.
- W2040617124 cites W2049510318 @default.
- W2040617124 cites W2056648984 @default.
- W2040617124 cites W2071354778 @default.
- W2040617124 cites W2074559096 @default.
- W2040617124 cites W2077580042 @default.
- W2040617124 cites W2078005557 @default.
- W2040617124 cites W2085877659 @default.
- W2040617124 cites W2095301528 @default.
- W2040617124 cites W2108072126 @default.
- W2040617124 cites W2109598533 @default.
- W2040617124 cites W2112773853 @default.
- W2040617124 cites W2113014296 @default.
- W2040617124 cites W2113320982 @default.
- W2040617124 cites W2123804432 @default.
- W2040617124 cites W2131668983 @default.
- W2040617124 cites W2132281009 @default.
- W2040617124 cites W2137854060 @default.
- W2040617124 cites W2138417832 @default.
- W2040617124 cites W2146141276 @default.
- W2040617124 cites W2147854065 @default.
- W2040617124 cites W2151391072 @default.
- W2040617124 cites W2163663923 @default.
- W2040617124 doi "https://doi.org/10.1016/j.freeradbiomed.2013.11.013" @default.
- W2040617124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24296244" @default.
- W2040617124 hasPublicationYear "2014" @default.
- W2040617124 type Work @default.
- W2040617124 sameAs 2040617124 @default.
- W2040617124 citedByCount "11" @default.
- W2040617124 countsByYear W20406171242014 @default.
- W2040617124 countsByYear W20406171242015 @default.
- W2040617124 countsByYear W20406171242016 @default.
- W2040617124 countsByYear W20406171242017 @default.
- W2040617124 countsByYear W20406171242019 @default.
- W2040617124 countsByYear W20406171242020 @default.
- W2040617124 countsByYear W20406171242021 @default.
- W2040617124 crossrefType "journal-article" @default.
- W2040617124 hasAuthorship W2040617124A5009696381 @default.
- W2040617124 hasAuthorship W2040617124A5013839751 @default.
- W2040617124 hasAuthorship W2040617124A5021161802 @default.
- W2040617124 hasAuthorship W2040617124A5024417004 @default.
- W2040617124 hasAuthorship W2040617124A5036614414 @default.
- W2040617124 hasAuthorship W2040617124A5048934963 @default.
- W2040617124 hasAuthorship W2040617124A5054067564 @default.
- W2040617124 hasAuthorship W2040617124A5071636149 @default.
- W2040617124 hasAuthorship W2040617124A5091776300 @default.
- W2040617124 hasConcept C104317684 @default.
- W2040617124 hasConcept C134935766 @default.
- W2040617124 hasConcept C141496672 @default.
- W2040617124 hasConcept C143425029 @default.
- W2040617124 hasConcept C153911025 @default.
- W2040617124 hasConcept C182704531 @default.
- W2040617124 hasConcept C187206112 @default.
- W2040617124 hasConcept C192396546 @default.
- W2040617124 hasConcept C2776151105 @default.
- W2040617124 hasConcept C2781119792 @default.
- W2040617124 hasConcept C2910616689 @default.
- W2040617124 hasConcept C48349386 @default.
- W2040617124 hasConcept C552990157 @default.
- W2040617124 hasConcept C55493867 @default.
- W2040617124 hasConcept C86803240 @default.
- W2040617124 hasConcept C95444343 @default.
- W2040617124 hasConceptScore W2040617124C104317684 @default.
- W2040617124 hasConceptScore W2040617124C134935766 @default.