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- W2040619384 abstract "Diets containing 0.25% theophylline were fed to rats in one daily meal or ad libitum. The rats grew normally and did not exhibit symptoms characteristic of theophylline toxicity. Theophylline feeding decreased the hepatic pyruvate carboxylase (PC) (EC 6.4.1.1), phosphoenolpyruvate carboxykinase (PEPck) (EC 4.1.1.32) and fructose 1,6-diphosphatase (FDPase) (EC 3.1.3.11) activities in both the meal fed and ad libitum fed animals. The activity of glucose-6-phosphatase (G6Pase) (EC 3.1.3.9) decreased in the meal-fed but increased in the ad libitum fed rat. Similarly, when expressed as per unit of body weight, the relative activities remain the same indicating that a true adaptation occurred. The findings suggest that chronic theophylline ingestion may inhibit gluconeogenesis by decreasing the activities of these regulatory enzymes." @default.
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- W2040619384 date "1972-07-01" @default.
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- W2040619384 title "The inhibitory effects of theophylline feeding on gluconeogenic enzymes in rat liver" @default.
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- W2040619384 doi "https://doi.org/10.1016/0024-3205(72)90014-8" @default.
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