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- W2040620925 abstract "<h2>Abstract</h2> The effects of morphine on arachidonic acid metabolism, on cAMP levels and on basal and induced <sup>45</sup>Ca<sup>2+</sup>-uptake, in uterine strips isolated from ovariectomized rats as well as the influence of naloxone, were explored. The presence of morphine (10<sup>−6</sup> M) did not change significantly <sup>14</sup>C-arachidonic acid metabolism, basal cAMP levels, or cAMP increment induced by PGE<sub>2</sub> or by PGE<sub>1</sub>. On the other hand morphine (10<sup>−6</sup> M) decreased basal uterine <sup>45</sup>Ca<sup>2+</sup>-uptake as much as verapamil (10<sup>−6</sup> M) did, and this action was not prevented by naloxone (10<sup>−8</sup> M). The presence of oxytocin (50 mU.ml<sup>−1</sup>) augmented <sup>45</sup>Ca<sup>2+</sup>-uptake, an effect which was antagonized by morphine (10<sup>−6</sup> M). This inhibitory action of morphine on oxytocin-induced <sup>45</sup>Ca<sup>2+</sup>-uptake was not prevented by naloxone (10<sup>−8</sup> M). Furthermore, PGE<sub>1</sub> (10<sup>−8</sup> M and 10<sup>−6</sup> M) but not PGE<sub>2</sub> (10<sup>−8</sup> and 10<sup>−6</sup> M), stimulated the incorporation of <sup>45</sup>Ca<sup>2+</sup> into uterine strips, and this action was not altered by morphine. The inhibitory influence of morphine on uterine spontaneous motility and on prostaglandin synthesis and release, previously described by us, is now explained in terms of an inhibition of tissue Ca<sup>2+</sup>-uptake." @default.
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- W2040620925 date "1990-11-01" @default.
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- W2040620925 title "Effects of morphine on arachidonic acid metabolism, on Ca2+- uptake and on cAMP synthesis in uterine strips from spayed rats" @default.
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- W2040620925 doi "https://doi.org/10.1016/0952-3278(90)90082-v" @default.
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