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- W2040621879 abstract "G-quadruplex DNA plays an important role in the potential therapeutic target for the design and development of anticancer drugs. As various G-quadruplex sequences in the promoter regions or telomeres can form different secondary structural modes and display a diversity of biology functions, variant G-quadruplex interactive agents may be necessary to cure different disease by differentiating variant types of G-quadruplexes. We synthesize five cationic methylpyridylium corroles and compare the interactions of corroles with different types of G-quadruplexes such as cmyc, htelo, and bcl2 by using surface plasmon resonance. Because of the importance of human telomere G-quadruplex DNA, we focus on the biological properties of the interactions between human telomere G-quadruplex DNA and corrole isomers using CD, T(m), PCR-stop (PCR= polymerase chain reaction), and polymerase-stop assay, which demonstrate the excellent ability of the corrole to induce and stabilize the G-quadruplex. This study provides the first experimental insight into how selectivity might be achieved for different G-quadruplexes by a single group of methylpyridylium corrole isomers that may be optimized for potential selective cancer therapy." @default.
- W2040621879 created "2016-06-24" @default.
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- W2040621879 date "2010-01-04" @default.
- W2040621879 modified "2023-10-02" @default.
- W2040621879 title "Pyridyl-Substituted Corrole Isomers: Synthesis and their Regulation to G-quadruplex Structures" @default.
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- W2040621879 doi "https://doi.org/10.1002/asia.200900270" @default.
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