FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040626093> ?p ?o ?g. }

• W2040626093 endingPage "4041" @default.
• W2040626093 startingPage "4031" @default.
• W2040626093 abstract "Abstract Using Southern blot analysis of RT-PCR products, mRNA for three different somatostatin (SS) precursors (PSS-I, -II, and -III), which encode for SS14, goldfish brain (gb)SS28, and [Pro2]SS14, respectively, were detected in goldfish hypothalamus. PSS-I and -II mRNA, but not PSS-III mRNA, were also detected in cultured pituitary cells. We subsequently examined the effects of the mature peptides, SS14, gbSS28, and [Pro2]SS14, on somatotrope signaling and GH secretion. The gbSS28 was more potent than either SS14 or [Pro2]SS14 in reducing basal GH release but was the least effective in reducing basal cellular cAMP. The ability of SS14, [Pro2]SS14, and gbSS28 to attenuate GH responses to GnRH were comparable. However, gbSS28 was less effective than SS14 and [Pro2]SS14 in diminishing dopamine- and pituitary adenylate cyclase-activating polypeptide-stimulated GH release, as well as GH release resulting from the activation of their underlying signaling cascades. In contrast, the actions of a different 28-amino-acid SS, mammalian SS28, were more similar to those of SS14 and [Pro2]SS14. We conclude that, in goldfish, SSs differentially couple to the intracellular cascades regulating GH secretion from pituitary somatotropes. This raises the possibility that such differences may allow for the selective regulation of various aspects of somatotrope function by different SS peptides." @default.
• W2040626093 created "2016-06-24" @default.
• W2040626093 creator A5003830977 @default.
• W2040626093 creator A5010183444 @default.
• W2040626093 creator A5011497642 @default.
• W2040626093 creator A5050975906 @default.
• W2040626093 creator A5051012703 @default.
• W2040626093 creator A5068974759 @default.
• W2040626093 creator A5087114967 @default.
• W2040626093 creator A5087261429 @default.
• W2040626093 date "2003-09-01" @default.
• W2040626093 modified "2023-10-17" @default.
• W2040626093 title "Endogenous Hypothalamic Somatostatins Differentially Regulate Growth Hormone Secretion from Goldfish Pituitary Somatotropes in Vitro" @default.
• W2040626093 cites W1506470516 @default.
• W2040626093 cites W1520689908 @default.
• W2040626093 cites W1539348837 @default.
• W2040626093 cites W1595059188 @default.
• W2040626093 cites W1596547035 @default.
• W2040626093 cites W1963540713 @default.
• W2040626093 cites W1969914832 @default.
• W2040626093 cites W1974138150 @default.
• W2040626093 cites W1974626719 @default.
• W2040626093 cites W1974773422 @default.
• W2040626093 cites W1983999057 @default.
• W2040626093 cites W1987155230 @default.
• W2040626093 cites W1990260477 @default.
• W2040626093 cites W1993137551 @default.
• W2040626093 cites W1995523723 @default.
• W2040626093 cites W2002137106 @default.
• W2040626093 cites W2003685364 @default.
• W2040626093 cites W2008309890 @default.
• W2040626093 cites W2009829090 @default.
• W2040626093 cites W2010880157 @default.
• W2040626093 cites W2010935675 @default.
• W2040626093 cites W2014410994 @default.
• W2040626093 cites W2016121702 @default.
• W2040626093 cites W2017558508 @default.
• W2040626093 cites W2020112785 @default.
• W2040626093 cites W2024781681 @default.
• W2040626093 cites W2025546412 @default.
• W2040626093 cites W2027636777 @default.
• W2040626093 cites W2030600722 @default.
• W2040626093 cites W2033090095 @default.
• W2040626093 cites W2043655641 @default.
• W2040626093 cites W2043679849 @default.
• W2040626093 cites W2044730918 @default.
• W2040626093 cites W2046905594 @default.
• W2040626093 cites W2051107041 @default.
• W2040626093 cites W2055262471 @default.
• W2040626093 cites W2056257770 @default.
• W2040626093 cites W2057344695 @default.
• W2040626093 cites W2060957786 @default.
• W2040626093 cites W2065843753 @default.
• W2040626093 cites W2071440404 @default.
• W2040626093 cites W2074657289 @default.
• W2040626093 cites W2080232093 @default.
• W2040626093 cites W2085917798 @default.
• W2040626093 cites W2100337567 @default.
• W2040626093 cites W2104667464 @default.
• W2040626093 cites W2113248936 @default.
• W2040626093 cites W2116536468 @default.
• W2040626093 cites W2132404412 @default.
• W2040626093 cites W2144743522 @default.
• W2040626093 cites W2155856484 @default.
• W2040626093 cites W2156424672 @default.
• W2040626093 cites W2165053368 @default.
• W2040626093 cites W289631350 @default.
• W2040626093 cites W4211249976 @default.
• W2040626093 doi "https://doi.org/10.1210/en.2003-0439" @default.
• W2040626093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12933677" @default.
• W2040626093 hasPublicationYear "2003" @default.
• W2040626093 type Work @default.
• W2040626093 sameAs 2040626093 @default.
• W2040626093 citedByCount "42" @default.
• W2040626093 countsByYear W20406260932012 @default.
• W2040626093 countsByYear W20406260932013 @default.
• W2040626093 countsByYear W20406260932014 @default.
• W2040626093 countsByYear W20406260932016 @default.
• W2040626093 countsByYear W20406260932018 @default.
• W2040626093 countsByYear W20406260932019 @default.
• W2040626093 countsByYear W20406260932020 @default.
• W2040626093 countsByYear W20406260932022 @default.
• W2040626093 countsByYear W20406260932023 @default.
• W2040626093 crossrefType "journal-article" @default.
• W2040626093 hasAuthorship W2040626093A5003830977 @default.
• W2040626093 hasAuthorship W2040626093A5010183444 @default.
• W2040626093 hasAuthorship W2040626093A5011497642 @default.
• W2040626093 hasAuthorship W2040626093A5050975906 @default.
• W2040626093 hasAuthorship W2040626093A5051012703 @default.
• W2040626093 hasAuthorship W2040626093A5068974759 @default.
• W2040626093 hasAuthorship W2040626093A5087114967 @default.
• W2040626093 hasAuthorship W2040626093A5087261429 @default.
• W2040626093 hasConcept C126322002 @default.
• W2040626093 hasConcept C134018914 @default.
• W2040626093 hasConcept C2776297358 @default.
• W2040626093 hasConcept C2777003273 @default.
• W2040626093 hasConcept C2777658017 @default.
• W2040626093 hasConcept C71315377 @default.

• next