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• W2040635024 endingPage "298" @default.
• W2040635024 startingPage "291" @default.
• W2040635024 abstract "The effect of systemic administration of the nonselective dopamine receptor agonist apomorphine on efflux of serotonin (5-hydroxytryptamine, 5-HT) in striatum and hippocampus of freely moving rats was examined using in vivo microdialysis. 5-HT efflux was increased by a moderate dose of apomorphine sufficient for a postsynaptic dopaminergic effect (0.5 mg/kg, s.c.), but not by a lower dose (0.1 mg/kg, s.c.), that acts preferentially on presynaptic dopamine receptors. This effect was blocked by a dopamine D2 receptor antagonist raclopride, administered either systemically or locally into striatum, but not by a 5-HT1A receptor antagonist N-{2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl}-N-(2-pyridinyl) cyclohexanecarboxamide 3HCl (WAY-100635). This indicates that dopamine D2 receptors, and not 5-HT1A receptors, mediate the facilitatory effect of apomorphine, and that this effect occurs at the nerve terminal level. Behavioral effects of apomorphine outlasted the concomitant changes in 5-HT efflux, suggesting that these changes resulted from dopaminergic receptor activation, rather than from the drug-induced behavioral arousal." @default.
• W2040635024 created "2016-06-24" @default.
• W2040635024 creator A5061111049 @default.
• W2040635024 creator A5065741199 @default.
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• W2040635024 date "1998-06-01" @default.
• W2040635024 modified "2023-10-17" @default.
• W2040635024 title "Involvement of dopamine D2 receptors in apomorphine-induced facilitation of forebrain serotonin output" @default.
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• W2040635024 doi "https://doi.org/10.1016/s0014-2999(98)00321-5" @default.
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