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- W2040638611 abstract "The localization of high-frequency sounds in the horizontal plane uses an interaural-level difference (ILD) cue, yet little is known about the synaptic mechanisms that underlie processing this cue in the inferior colliculus (IC) of mouse. Here, we study the synaptic currents that process ILD in vivo and use stimuli in which ILD varies around a constant average binaural level (ABL) to approximate sounds on the horizontal plane. Monaural stimulation in either ear produced EPSCs and IPSCs in most neurons. The temporal properties of monaural responses were well matched, suggesting connected functional zones with matched inputs. The EPSCs had three patterns in response to ABL stimuli, preference for the sound field with the highest level stimulus: (1) contralateral; (2) bilateral highly lateralized; or (3) at the center near 0 ILD. EPSCs and IPSCs were well correlated except in center-preferred neurons. Summation of the monaural EPSCs predicted the binaural excitatory response but less well than the summation of monaural IPSCs. Binaural EPSCs often showed a nonlinearity that strengthened the response to specific ILDs. Extracellular spike and intracellular current recordings from the same neuron showed that the ILD tuning of the spikes was sharper than that of the EPSCs. Thus, in the IC, balanced excitatory and inhibitory inputs may be a general feature of synaptic coding for many types of sound processing." @default.
- W2040638611 created "2016-06-24" @default.
- W2040638611 creator A5010569359 @default.
- W2040638611 creator A5017277035 @default.
- W2040638611 date "2014-03-05" @default.
- W2040638611 modified "2023-10-16" @default.
- W2040638611 title "The Balance of Excitatory and Inhibitory Synaptic Inputs for Coding Sound Location" @default.
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- W2040638611 doi "https://doi.org/10.1523/jneurosci.2954-13.2014" @default.
- W2040638611 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3942590" @default.
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